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Optimization of Technological Parameters of the Process of Forming Therapeutic Biopolymer Nanofilled Films

The prospects of using biopolymer nano-containing films for wound healing were substantiated. The main components of biopolymer composites are gelatin, polyvinyl alcohol, glycerin, lactic acid, distilled water, and zinc oxide (ZnO) nanoparticles (NPs). Biopolymer composites were produced according t...

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Autores principales: Bembenek, Michał, Popadyuk, Oleg, Shihab, Thaer, Ropyak, Liubomyr, Uhryński, Andrzej, Vytvytskyi, Vasyl, Bulbuk, Oleksandr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9318775/
https://www.ncbi.nlm.nih.gov/pubmed/35889643
http://dx.doi.org/10.3390/nano12142413
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author Bembenek, Michał
Popadyuk, Oleg
Shihab, Thaer
Ropyak, Liubomyr
Uhryński, Andrzej
Vytvytskyi, Vasyl
Bulbuk, Oleksandr
author_facet Bembenek, Michał
Popadyuk, Oleg
Shihab, Thaer
Ropyak, Liubomyr
Uhryński, Andrzej
Vytvytskyi, Vasyl
Bulbuk, Oleksandr
author_sort Bembenek, Michał
collection PubMed
description The prospects of using biopolymer nano-containing films for wound healing were substantiated. The main components of biopolymer composites are gelatin, polyvinyl alcohol, glycerin, lactic acid, distilled water, and zinc oxide (ZnO) nanoparticles (NPs). Biopolymer composites were produced according to various technological parameters using a mould with a chrome coating. The therapeutic properties of biopolymer films were evaluated by measuring the diameter of the protective effect. Physico-mechanical properties were studied: elasticity, vapour permeability, degradation time, and swelling. To study the influence of technological parameters of the formation process of therapeutic biopolymer nanofilled films on their therapeutic and physico-mechanical properties, the planning of the experiment was used. According to the results of the experiments, mathematical models of the second-order were built. The optimal values of technological parameters of the process are determined, which provide biopolymer nanofilled films with maximum healing ability (diameter of protective action) and sufficiently high physical and mechanical properties: elasticity, vapour permeability, degradation time and swelling. The research results showed that the healing properties of biopolymer films mainly depend on the content of ZnO NPs. Degradation of these biopolymer films provides dosed drug delivery to the affected area. The products of destruction are carbon dioxide, water, and a small amount of ZnO in the bound state, which indicates the environmental safety of the developed biopolymer film.
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spelling pubmed-93187752022-07-27 Optimization of Technological Parameters of the Process of Forming Therapeutic Biopolymer Nanofilled Films Bembenek, Michał Popadyuk, Oleg Shihab, Thaer Ropyak, Liubomyr Uhryński, Andrzej Vytvytskyi, Vasyl Bulbuk, Oleksandr Nanomaterials (Basel) Article The prospects of using biopolymer nano-containing films for wound healing were substantiated. The main components of biopolymer composites are gelatin, polyvinyl alcohol, glycerin, lactic acid, distilled water, and zinc oxide (ZnO) nanoparticles (NPs). Biopolymer composites were produced according to various technological parameters using a mould with a chrome coating. The therapeutic properties of biopolymer films were evaluated by measuring the diameter of the protective effect. Physico-mechanical properties were studied: elasticity, vapour permeability, degradation time, and swelling. To study the influence of technological parameters of the formation process of therapeutic biopolymer nanofilled films on their therapeutic and physico-mechanical properties, the planning of the experiment was used. According to the results of the experiments, mathematical models of the second-order were built. The optimal values of technological parameters of the process are determined, which provide biopolymer nanofilled films with maximum healing ability (diameter of protective action) and sufficiently high physical and mechanical properties: elasticity, vapour permeability, degradation time and swelling. The research results showed that the healing properties of biopolymer films mainly depend on the content of ZnO NPs. Degradation of these biopolymer films provides dosed drug delivery to the affected area. The products of destruction are carbon dioxide, water, and a small amount of ZnO in the bound state, which indicates the environmental safety of the developed biopolymer film. MDPI 2022-07-14 /pmc/articles/PMC9318775/ /pubmed/35889643 http://dx.doi.org/10.3390/nano12142413 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bembenek, Michał
Popadyuk, Oleg
Shihab, Thaer
Ropyak, Liubomyr
Uhryński, Andrzej
Vytvytskyi, Vasyl
Bulbuk, Oleksandr
Optimization of Technological Parameters of the Process of Forming Therapeutic Biopolymer Nanofilled Films
title Optimization of Technological Parameters of the Process of Forming Therapeutic Biopolymer Nanofilled Films
title_full Optimization of Technological Parameters of the Process of Forming Therapeutic Biopolymer Nanofilled Films
title_fullStr Optimization of Technological Parameters of the Process of Forming Therapeutic Biopolymer Nanofilled Films
title_full_unstemmed Optimization of Technological Parameters of the Process of Forming Therapeutic Biopolymer Nanofilled Films
title_short Optimization of Technological Parameters of the Process of Forming Therapeutic Biopolymer Nanofilled Films
title_sort optimization of technological parameters of the process of forming therapeutic biopolymer nanofilled films
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9318775/
https://www.ncbi.nlm.nih.gov/pubmed/35889643
http://dx.doi.org/10.3390/nano12142413
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