Prevalence of Human Papilloma Virus Infection in Bladder Cancer: A Systematic Review

The etiology of bladder cancer is known to be associated with behavioral and environmental factors. Moreover, several studies suggested a potential role of HPV infection in the pathogenesis with controversial results. A systematic review was conducted to assess the role of HPV. A total of 46 article...

Descripción completa

Detalles Bibliográficos
Autores principales: Muresu, Narcisa, Di Lorenzo, Biagio, Saderi, Laura, Sechi, Illari, Del Rio, Arcadia, Piana, Andrea, Sotgiu, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Systematic Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9318826/
https://www.ncbi.nlm.nih.gov/pubmed/35885662
http://dx.doi.org/10.3390/diagnostics12071759
Descripción
Sumario:The etiology of bladder cancer is known to be associated with behavioral and environmental factors. Moreover, several studies suggested a potential role of HPV infection in the pathogenesis with controversial results. A systematic review was conducted to assess the role of HPV. A total of 46 articles that reported the prevalence of HPV infection in squamous (SCC), urothelial (UC), and transitional cell carcinomas (TCC) were selected. A pooled prevalence of 19% was found, with a significant difference in SCC that was mainly driven by HPV-16. Moreover, infection prevalence in case-control studies showed a higher risk of bladder cancer in HPV-positive cases (OR: 7.84; p-value < 0.00001). The results may suggest an etiologic role of HPV in bladder cancer. HPV vaccine administration in both sexes could be key to prevent the infection caused by high-risk genotypes.

Ejemplares similares