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Cardiac Troponin Biosensor Designs: Current Developments and Remaining Challenges
Acute myocardial infarction (AMI) is considered as one of the main causes of death, threating human lives for decades. Currently, its diagnosis relies on electrocardiography (ECG), which has been proven to be insufficient. In this context, the efficient detection of cardiac biomarkers was proposed t...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9318943/ https://www.ncbi.nlm.nih.gov/pubmed/35887073 http://dx.doi.org/10.3390/ijms23147728 |
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author | Campu, Andreea Muresan, Ilinca Craciun, Ana-Maria Cainap, Simona Astilean, Simion Focsan, Monica |
author_facet | Campu, Andreea Muresan, Ilinca Craciun, Ana-Maria Cainap, Simona Astilean, Simion Focsan, Monica |
author_sort | Campu, Andreea |
collection | PubMed |
description | Acute myocardial infarction (AMI) is considered as one of the main causes of death, threating human lives for decades. Currently, its diagnosis relies on electrocardiography (ECG), which has been proven to be insufficient. In this context, the efficient detection of cardiac biomarkers was proposed to overcome the limitations of ECG. In particular, the measurement of troponins, specifically cardiac troponin I (cTnI) and cardiac troponin T (cTnT), has proven to be superior in terms of sensitivity and specificity in the diagnosis of myocardial damage. As one of the most life-threatening conditions, specific and sensitive investigation methods that are fast, universally available, and cost-efficient to allow for early initiation of evidence-based, living-saving treatment are desired. In this review, we aim to present and discuss the major breakthroughs made in the development of cTnI and cTnT specific biosensor designs and analytical tools, highlighting the achieved progress as well as the remaining challenges to reach the technological goal of simple, specific, cheap, and portable testing chips for the rapid and efficient on-site detection of cardiac cTnI/cTnT biomarkers in order to diagnose and treat cardiovascular diseases at an incipient stage. |
format | Online Article Text |
id | pubmed-9318943 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93189432022-07-27 Cardiac Troponin Biosensor Designs: Current Developments and Remaining Challenges Campu, Andreea Muresan, Ilinca Craciun, Ana-Maria Cainap, Simona Astilean, Simion Focsan, Monica Int J Mol Sci Review Acute myocardial infarction (AMI) is considered as one of the main causes of death, threating human lives for decades. Currently, its diagnosis relies on electrocardiography (ECG), which has been proven to be insufficient. In this context, the efficient detection of cardiac biomarkers was proposed to overcome the limitations of ECG. In particular, the measurement of troponins, specifically cardiac troponin I (cTnI) and cardiac troponin T (cTnT), has proven to be superior in terms of sensitivity and specificity in the diagnosis of myocardial damage. As one of the most life-threatening conditions, specific and sensitive investigation methods that are fast, universally available, and cost-efficient to allow for early initiation of evidence-based, living-saving treatment are desired. In this review, we aim to present and discuss the major breakthroughs made in the development of cTnI and cTnT specific biosensor designs and analytical tools, highlighting the achieved progress as well as the remaining challenges to reach the technological goal of simple, specific, cheap, and portable testing chips for the rapid and efficient on-site detection of cardiac cTnI/cTnT biomarkers in order to diagnose and treat cardiovascular diseases at an incipient stage. MDPI 2022-07-13 /pmc/articles/PMC9318943/ /pubmed/35887073 http://dx.doi.org/10.3390/ijms23147728 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Campu, Andreea Muresan, Ilinca Craciun, Ana-Maria Cainap, Simona Astilean, Simion Focsan, Monica Cardiac Troponin Biosensor Designs: Current Developments and Remaining Challenges |
title | Cardiac Troponin Biosensor Designs: Current Developments and Remaining Challenges |
title_full | Cardiac Troponin Biosensor Designs: Current Developments and Remaining Challenges |
title_fullStr | Cardiac Troponin Biosensor Designs: Current Developments and Remaining Challenges |
title_full_unstemmed | Cardiac Troponin Biosensor Designs: Current Developments and Remaining Challenges |
title_short | Cardiac Troponin Biosensor Designs: Current Developments and Remaining Challenges |
title_sort | cardiac troponin biosensor designs: current developments and remaining challenges |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9318943/ https://www.ncbi.nlm.nih.gov/pubmed/35887073 http://dx.doi.org/10.3390/ijms23147728 |
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