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Peeling Back the Layers of Lymph Gland Structure and Regulation
During the past 60 years, the fruit fly, Drosophila melanogaster, has proven to be an excellent model to study the regulation of hematopoiesis. This is not only due to the evolutionarily conserved signalling pathways and transcription factors contributing to blood cell fate, but also to convergent e...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319083/ https://www.ncbi.nlm.nih.gov/pubmed/35887113 http://dx.doi.org/10.3390/ijms23147767 |
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author | Kharrat, Bayan Csordás, Gábor Honti, Viktor |
author_facet | Kharrat, Bayan Csordás, Gábor Honti, Viktor |
author_sort | Kharrat, Bayan |
collection | PubMed |
description | During the past 60 years, the fruit fly, Drosophila melanogaster, has proven to be an excellent model to study the regulation of hematopoiesis. This is not only due to the evolutionarily conserved signalling pathways and transcription factors contributing to blood cell fate, but also to convergent evolution that led to functional similarities in distinct species. An example of convergence is the compartmentalization of blood cells, which ensures the quiescence of hematopoietic stem cells and allows for the rapid reaction of the immune system upon challenges. The lymph gland, a widely studied hematopoietic organ of the Drosophila larva, represents a microenvironment with similar features and functions to classical hematopoietic stem cell niches of vertebrates. Lymph gland studies were effectively supported by the unparalleled toolkit developed in Drosophila, which enabled the high-resolution investigation of the cellular composition and regulatory interaction networks of the lymph gland. In this review, we summarize how our understanding of lymph gland structure and hematopoietic cell-to-cell communication evolved during the past decades and compare their analogous features to those of the vertebrate hematopoietic stem cell niche. |
format | Online Article Text |
id | pubmed-9319083 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93190832022-07-27 Peeling Back the Layers of Lymph Gland Structure and Regulation Kharrat, Bayan Csordás, Gábor Honti, Viktor Int J Mol Sci Review During the past 60 years, the fruit fly, Drosophila melanogaster, has proven to be an excellent model to study the regulation of hematopoiesis. This is not only due to the evolutionarily conserved signalling pathways and transcription factors contributing to blood cell fate, but also to convergent evolution that led to functional similarities in distinct species. An example of convergence is the compartmentalization of blood cells, which ensures the quiescence of hematopoietic stem cells and allows for the rapid reaction of the immune system upon challenges. The lymph gland, a widely studied hematopoietic organ of the Drosophila larva, represents a microenvironment with similar features and functions to classical hematopoietic stem cell niches of vertebrates. Lymph gland studies were effectively supported by the unparalleled toolkit developed in Drosophila, which enabled the high-resolution investigation of the cellular composition and regulatory interaction networks of the lymph gland. In this review, we summarize how our understanding of lymph gland structure and hematopoietic cell-to-cell communication evolved during the past decades and compare their analogous features to those of the vertebrate hematopoietic stem cell niche. MDPI 2022-07-14 /pmc/articles/PMC9319083/ /pubmed/35887113 http://dx.doi.org/10.3390/ijms23147767 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Kharrat, Bayan Csordás, Gábor Honti, Viktor Peeling Back the Layers of Lymph Gland Structure and Regulation |
title | Peeling Back the Layers of Lymph Gland Structure and Regulation |
title_full | Peeling Back the Layers of Lymph Gland Structure and Regulation |
title_fullStr | Peeling Back the Layers of Lymph Gland Structure and Regulation |
title_full_unstemmed | Peeling Back the Layers of Lymph Gland Structure and Regulation |
title_short | Peeling Back the Layers of Lymph Gland Structure and Regulation |
title_sort | peeling back the layers of lymph gland structure and regulation |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319083/ https://www.ncbi.nlm.nih.gov/pubmed/35887113 http://dx.doi.org/10.3390/ijms23147767 |
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