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Sulfated Galactofucans: An Outstanding Class of Fucoidans with Promising Bioactivities

Fucoidans encompass versatile and heterogeneous sulfated biopolysaccharides of marine origin, specifically brown algae and marine invertebrates. Their chemistry and bioactivities have been extensively investigated in the last few decades. The reported studies revealed diverse chemical skeletons in w...

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Autores principales: Zayed, Ahmed, Avila-Peltroche, Jose, El-Aasr, Mona, Ulber, Roland
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319086/
https://www.ncbi.nlm.nih.gov/pubmed/35877705
http://dx.doi.org/10.3390/md20070412
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author Zayed, Ahmed
Avila-Peltroche, Jose
El-Aasr, Mona
Ulber, Roland
author_facet Zayed, Ahmed
Avila-Peltroche, Jose
El-Aasr, Mona
Ulber, Roland
author_sort Zayed, Ahmed
collection PubMed
description Fucoidans encompass versatile and heterogeneous sulfated biopolysaccharides of marine origin, specifically brown algae and marine invertebrates. Their chemistry and bioactivities have been extensively investigated in the last few decades. The reported studies revealed diverse chemical skeletons in which l-fucose is the main sugar monomer. However, other sugars, i.e., galactose, mannose, etc., have been identified to be interspersed, forming several heteropolymers, including galactofucans/fucogalactans (G-fucoidans). Particularly, sulfated galactofucans are associated with rich chemistry contributing to more promising bioactivities than fucans and other marine polysaccharides. The previous reports in the last 20 years showed that G-fucoidans derived from Undaria pinnatifida were the most studied; 21 bioactivities were investigated, especially antitumor and antiviral activities, and unique biomedical applications compared to other marine polysaccharides were demonstrated. Hence, the current article specifically reviews the biogenic sources, chemistry, and outstanding bioactivities of G-fucoidans providing the opportunity to discover novel drug candidates.
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spelling pubmed-93190862022-07-27 Sulfated Galactofucans: An Outstanding Class of Fucoidans with Promising Bioactivities Zayed, Ahmed Avila-Peltroche, Jose El-Aasr, Mona Ulber, Roland Mar Drugs Review Fucoidans encompass versatile and heterogeneous sulfated biopolysaccharides of marine origin, specifically brown algae and marine invertebrates. Their chemistry and bioactivities have been extensively investigated in the last few decades. The reported studies revealed diverse chemical skeletons in which l-fucose is the main sugar monomer. However, other sugars, i.e., galactose, mannose, etc., have been identified to be interspersed, forming several heteropolymers, including galactofucans/fucogalactans (G-fucoidans). Particularly, sulfated galactofucans are associated with rich chemistry contributing to more promising bioactivities than fucans and other marine polysaccharides. The previous reports in the last 20 years showed that G-fucoidans derived from Undaria pinnatifida were the most studied; 21 bioactivities were investigated, especially antitumor and antiviral activities, and unique biomedical applications compared to other marine polysaccharides were demonstrated. Hence, the current article specifically reviews the biogenic sources, chemistry, and outstanding bioactivities of G-fucoidans providing the opportunity to discover novel drug candidates. MDPI 2022-06-24 /pmc/articles/PMC9319086/ /pubmed/35877705 http://dx.doi.org/10.3390/md20070412 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zayed, Ahmed
Avila-Peltroche, Jose
El-Aasr, Mona
Ulber, Roland
Sulfated Galactofucans: An Outstanding Class of Fucoidans with Promising Bioactivities
title Sulfated Galactofucans: An Outstanding Class of Fucoidans with Promising Bioactivities
title_full Sulfated Galactofucans: An Outstanding Class of Fucoidans with Promising Bioactivities
title_fullStr Sulfated Galactofucans: An Outstanding Class of Fucoidans with Promising Bioactivities
title_full_unstemmed Sulfated Galactofucans: An Outstanding Class of Fucoidans with Promising Bioactivities
title_short Sulfated Galactofucans: An Outstanding Class of Fucoidans with Promising Bioactivities
title_sort sulfated galactofucans: an outstanding class of fucoidans with promising bioactivities
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319086/
https://www.ncbi.nlm.nih.gov/pubmed/35877705
http://dx.doi.org/10.3390/md20070412
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