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Extreme Interocular Asymmetry in an Atypical Case of a Hydroxychloroquine-Related Retinopathy
Background and Objectives: Long-term hydroxychloroquine (HCQ) therapy can lead to retinal toxicity. Typically, it is characterized by a bull’s eye maculopathy. More recently, a “pericentral” form of HCQ retinopathy that predominantly affects patients of Asian descent has been described. To our knowl...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319118/ https://www.ncbi.nlm.nih.gov/pubmed/35888686 http://dx.doi.org/10.3390/medicina58070967 |
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author | Hallali, Gabriel Seyed, Zari Maillard, Anne-Véronique Drine, Karima Lamour, Laurence Faure, Céline Audo, Isabelle |
author_facet | Hallali, Gabriel Seyed, Zari Maillard, Anne-Véronique Drine, Karima Lamour, Laurence Faure, Céline Audo, Isabelle |
author_sort | Hallali, Gabriel |
collection | PubMed |
description | Background and Objectives: Long-term hydroxychloroquine (HCQ) therapy can lead to retinal toxicity. Typically, it is characterized by a bull’s eye maculopathy. More recently, a “pericentral” form of HCQ retinopathy that predominantly affects patients of Asian descent has been described. To our knowledge, this is the first reported case where such an asymmetry between the right and the left eye in the toxicity profile is observed. Case presentation: The patient presented with a 12-year exposure to HCQ at a daily dose of 4.35 mg/kg. She presented an inferior pericentral-only phenotype of HCQ toxicity on the right eye and a perifoveal-only toxicity on the left eye. Modest progression of toxicity was observed on both eyes over the seven years of follow-up, despite drug discontinuation. Conclusions: To our knowledge, this is the first time that two different phenotypes of HCQ-related retinopathy are found in the same patient, challenging our understanding of the pathophysiology of HCQ retinal toxicity. |
format | Online Article Text |
id | pubmed-9319118 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93191182022-07-27 Extreme Interocular Asymmetry in an Atypical Case of a Hydroxychloroquine-Related Retinopathy Hallali, Gabriel Seyed, Zari Maillard, Anne-Véronique Drine, Karima Lamour, Laurence Faure, Céline Audo, Isabelle Medicina (Kaunas) Case Report Background and Objectives: Long-term hydroxychloroquine (HCQ) therapy can lead to retinal toxicity. Typically, it is characterized by a bull’s eye maculopathy. More recently, a “pericentral” form of HCQ retinopathy that predominantly affects patients of Asian descent has been described. To our knowledge, this is the first reported case where such an asymmetry between the right and the left eye in the toxicity profile is observed. Case presentation: The patient presented with a 12-year exposure to HCQ at a daily dose of 4.35 mg/kg. She presented an inferior pericentral-only phenotype of HCQ toxicity on the right eye and a perifoveal-only toxicity on the left eye. Modest progression of toxicity was observed on both eyes over the seven years of follow-up, despite drug discontinuation. Conclusions: To our knowledge, this is the first time that two different phenotypes of HCQ-related retinopathy are found in the same patient, challenging our understanding of the pathophysiology of HCQ retinal toxicity. MDPI 2022-07-21 /pmc/articles/PMC9319118/ /pubmed/35888686 http://dx.doi.org/10.3390/medicina58070967 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Hallali, Gabriel Seyed, Zari Maillard, Anne-Véronique Drine, Karima Lamour, Laurence Faure, Céline Audo, Isabelle Extreme Interocular Asymmetry in an Atypical Case of a Hydroxychloroquine-Related Retinopathy |
title | Extreme Interocular Asymmetry in an Atypical Case of a Hydroxychloroquine-Related Retinopathy |
title_full | Extreme Interocular Asymmetry in an Atypical Case of a Hydroxychloroquine-Related Retinopathy |
title_fullStr | Extreme Interocular Asymmetry in an Atypical Case of a Hydroxychloroquine-Related Retinopathy |
title_full_unstemmed | Extreme Interocular Asymmetry in an Atypical Case of a Hydroxychloroquine-Related Retinopathy |
title_short | Extreme Interocular Asymmetry in an Atypical Case of a Hydroxychloroquine-Related Retinopathy |
title_sort | extreme interocular asymmetry in an atypical case of a hydroxychloroquine-related retinopathy |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319118/ https://www.ncbi.nlm.nih.gov/pubmed/35888686 http://dx.doi.org/10.3390/medicina58070967 |
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