The Role of Insect Symbiotic Bacteria in Metabolizing Phytochemicals and Agrochemicals

SIMPLE SUMMARY: To counter plant chemical defenses and exposure to agrochemicals, herbivorous insects have developed several adaptive strategies to guard against the ingested detrimental substances, including enhancing detoxifying enzyme activities, avoidance behavior, amino acid mutation of target sites, and lower penetration through a thicker cuticle. Insect microbiota play important roles in many aspects of insect biology and physiology. To better understand the role of insect symbiotic bacteria in metabolizing these detrimental substances, we summarize the research progress on the function of insect bacteria in metabolizing phytochemicals and agrochemicals, and describe their future potential application in pest management and protection of beneficial insects. ABSTRACT: The diversity and high adaptability of insects are heavily associated with their symbiotic microbes, which include bacteria, fungi, viruses, protozoa, and archaea. These microbes play important roles in many aspects of the biology and physiology of insects, such as helping the host insects with food digestion, nutrition absorption, strengthening immunity and confronting plant defenses. To maintain normal development and population reproduction, herbivorous insects have developed strategies to detoxify the substances to which they may be exposed in the living habitat, such as the detoxifying enzymes carboxylesterase, glutathione-S-transferases (GSTs), and cytochrome P450 monooxygenases (CYP450s). Additionally, insect symbiotic bacteria can act as an important factor to modulate the adaptability of insects to the exposed detrimental substances. This review summarizes the current research progress on the role of insect symbiotic bacteria in metabolizing phytochemicals and agrochemicals (insecticides and herbicides). Given the importance of insect microbiota, more functional symbiotic bacteria that modulate the adaptability of insects to the detrimental substances to which they are exposed should be identified, and the underlying mechanisms should also be further studied, facilitating the development of microbial-resource-based pest control approaches or protective methods for beneficial insects.