Cargando…
Two Pediatric Cases of Multisystem Inflammatory Syndrome with Overlapping Neurological Involvement Following SARS-CoV-2 Vaccination and Unknown SARS-CoV2 Infection: The Importance of Pre-Vaccination History
The SARS-CoV-2 vaccine roll-out has been successful around the world. However, there are increasing concerns about adverse events. We report two pediatric cases of Multisystem-Inflammatory-Syndrome (MIS-C) with neurological involvement that occurred after SARS-CoV-2 vaccination and unknown recent SA...
Autores principales: | , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319257/ https://www.ncbi.nlm.nih.gov/pubmed/35891300 http://dx.doi.org/10.3390/vaccines10071136 |
_version_ | 1784755505493704704 |
---|---|
author | Santilli, Veronica Manno, Emma Concetta Giancotta, Carmela Rossetti, Chiara Cotugno, Nicola Amodio, Donato Rotulo, Gioacchino Andrea Deodati, Annalisa Bianchi, Roberto Lucignani, Giulia Longo, Daniela Valeriani, Massimiliano Palma, Paolo |
author_facet | Santilli, Veronica Manno, Emma Concetta Giancotta, Carmela Rossetti, Chiara Cotugno, Nicola Amodio, Donato Rotulo, Gioacchino Andrea Deodati, Annalisa Bianchi, Roberto Lucignani, Giulia Longo, Daniela Valeriani, Massimiliano Palma, Paolo |
author_sort | Santilli, Veronica |
collection | PubMed |
description | The SARS-CoV-2 vaccine roll-out has been successful around the world. However, there are increasing concerns about adverse events. We report two pediatric cases of Multisystem-Inflammatory-Syndrome (MIS-C) with neurological involvement that occurred after SARS-CoV-2 vaccination and unknown recent SARS-CoV-2 infection. Brain magnetic resonance revealed mild-encephalopathy with reversible-splenial-lesion in both cases and complete resolution within 4 weeks. In conclusion, this report aims to describe rare emerging clinical entities that can help pediatricians to make an early diagnosis and to provide appropriate treatment. Multisystem-Inflammatory-Syndromes following COVID-19 vaccination remain rare events. When a history of a recent contact with SARS-CoV-2 is present, a careful evaluation by the clinicians in charge of immunization activities is suggested prior to proceeding with the vaccination. |
format | Online Article Text |
id | pubmed-9319257 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93192572022-07-27 Two Pediatric Cases of Multisystem Inflammatory Syndrome with Overlapping Neurological Involvement Following SARS-CoV-2 Vaccination and Unknown SARS-CoV2 Infection: The Importance of Pre-Vaccination History Santilli, Veronica Manno, Emma Concetta Giancotta, Carmela Rossetti, Chiara Cotugno, Nicola Amodio, Donato Rotulo, Gioacchino Andrea Deodati, Annalisa Bianchi, Roberto Lucignani, Giulia Longo, Daniela Valeriani, Massimiliano Palma, Paolo Vaccines (Basel) Case Report The SARS-CoV-2 vaccine roll-out has been successful around the world. However, there are increasing concerns about adverse events. We report two pediatric cases of Multisystem-Inflammatory-Syndrome (MIS-C) with neurological involvement that occurred after SARS-CoV-2 vaccination and unknown recent SARS-CoV-2 infection. Brain magnetic resonance revealed mild-encephalopathy with reversible-splenial-lesion in both cases and complete resolution within 4 weeks. In conclusion, this report aims to describe rare emerging clinical entities that can help pediatricians to make an early diagnosis and to provide appropriate treatment. Multisystem-Inflammatory-Syndromes following COVID-19 vaccination remain rare events. When a history of a recent contact with SARS-CoV-2 is present, a careful evaluation by the clinicians in charge of immunization activities is suggested prior to proceeding with the vaccination. MDPI 2022-07-16 /pmc/articles/PMC9319257/ /pubmed/35891300 http://dx.doi.org/10.3390/vaccines10071136 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Santilli, Veronica Manno, Emma Concetta Giancotta, Carmela Rossetti, Chiara Cotugno, Nicola Amodio, Donato Rotulo, Gioacchino Andrea Deodati, Annalisa Bianchi, Roberto Lucignani, Giulia Longo, Daniela Valeriani, Massimiliano Palma, Paolo Two Pediatric Cases of Multisystem Inflammatory Syndrome with Overlapping Neurological Involvement Following SARS-CoV-2 Vaccination and Unknown SARS-CoV2 Infection: The Importance of Pre-Vaccination History |
title | Two Pediatric Cases of Multisystem Inflammatory Syndrome with Overlapping Neurological Involvement Following SARS-CoV-2 Vaccination and Unknown SARS-CoV2 Infection: The Importance of Pre-Vaccination History |
title_full | Two Pediatric Cases of Multisystem Inflammatory Syndrome with Overlapping Neurological Involvement Following SARS-CoV-2 Vaccination and Unknown SARS-CoV2 Infection: The Importance of Pre-Vaccination History |
title_fullStr | Two Pediatric Cases of Multisystem Inflammatory Syndrome with Overlapping Neurological Involvement Following SARS-CoV-2 Vaccination and Unknown SARS-CoV2 Infection: The Importance of Pre-Vaccination History |
title_full_unstemmed | Two Pediatric Cases of Multisystem Inflammatory Syndrome with Overlapping Neurological Involvement Following SARS-CoV-2 Vaccination and Unknown SARS-CoV2 Infection: The Importance of Pre-Vaccination History |
title_short | Two Pediatric Cases of Multisystem Inflammatory Syndrome with Overlapping Neurological Involvement Following SARS-CoV-2 Vaccination and Unknown SARS-CoV2 Infection: The Importance of Pre-Vaccination History |
title_sort | two pediatric cases of multisystem inflammatory syndrome with overlapping neurological involvement following sars-cov-2 vaccination and unknown sars-cov2 infection: the importance of pre-vaccination history |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319257/ https://www.ncbi.nlm.nih.gov/pubmed/35891300 http://dx.doi.org/10.3390/vaccines10071136 |
work_keys_str_mv | AT santilliveronica twopediatriccasesofmultisysteminflammatorysyndromewithoverlappingneurologicalinvolvementfollowingsarscov2vaccinationandunknownsarscov2infectiontheimportanceofprevaccinationhistory AT mannoemmaconcetta twopediatriccasesofmultisysteminflammatorysyndromewithoverlappingneurologicalinvolvementfollowingsarscov2vaccinationandunknownsarscov2infectiontheimportanceofprevaccinationhistory AT giancottacarmela twopediatriccasesofmultisysteminflammatorysyndromewithoverlappingneurologicalinvolvementfollowingsarscov2vaccinationandunknownsarscov2infectiontheimportanceofprevaccinationhistory AT rossettichiara twopediatriccasesofmultisysteminflammatorysyndromewithoverlappingneurologicalinvolvementfollowingsarscov2vaccinationandunknownsarscov2infectiontheimportanceofprevaccinationhistory AT cotugnonicola twopediatriccasesofmultisysteminflammatorysyndromewithoverlappingneurologicalinvolvementfollowingsarscov2vaccinationandunknownsarscov2infectiontheimportanceofprevaccinationhistory AT amodiodonato twopediatriccasesofmultisysteminflammatorysyndromewithoverlappingneurologicalinvolvementfollowingsarscov2vaccinationandunknownsarscov2infectiontheimportanceofprevaccinationhistory AT rotulogioacchinoandrea twopediatriccasesofmultisysteminflammatorysyndromewithoverlappingneurologicalinvolvementfollowingsarscov2vaccinationandunknownsarscov2infectiontheimportanceofprevaccinationhistory AT deodatiannalisa twopediatriccasesofmultisysteminflammatorysyndromewithoverlappingneurologicalinvolvementfollowingsarscov2vaccinationandunknownsarscov2infectiontheimportanceofprevaccinationhistory AT bianchiroberto twopediatriccasesofmultisysteminflammatorysyndromewithoverlappingneurologicalinvolvementfollowingsarscov2vaccinationandunknownsarscov2infectiontheimportanceofprevaccinationhistory AT lucignanigiulia twopediatriccasesofmultisysteminflammatorysyndromewithoverlappingneurologicalinvolvementfollowingsarscov2vaccinationandunknownsarscov2infectiontheimportanceofprevaccinationhistory AT longodaniela twopediatriccasesofmultisysteminflammatorysyndromewithoverlappingneurologicalinvolvementfollowingsarscov2vaccinationandunknownsarscov2infectiontheimportanceofprevaccinationhistory AT valerianimassimiliano twopediatriccasesofmultisysteminflammatorysyndromewithoverlappingneurologicalinvolvementfollowingsarscov2vaccinationandunknownsarscov2infectiontheimportanceofprevaccinationhistory AT palmapaolo twopediatriccasesofmultisysteminflammatorysyndromewithoverlappingneurologicalinvolvementfollowingsarscov2vaccinationandunknownsarscov2infectiontheimportanceofprevaccinationhistory |