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Two Pediatric Cases of Multisystem Inflammatory Syndrome with Overlapping Neurological Involvement Following SARS-CoV-2 Vaccination and Unknown SARS-CoV2 Infection: The Importance of Pre-Vaccination History

The SARS-CoV-2 vaccine roll-out has been successful around the world. However, there are increasing concerns about adverse events. We report two pediatric cases of Multisystem-Inflammatory-Syndrome (MIS-C) with neurological involvement that occurred after SARS-CoV-2 vaccination and unknown recent SA...

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Autores principales: Santilli, Veronica, Manno, Emma Concetta, Giancotta, Carmela, Rossetti, Chiara, Cotugno, Nicola, Amodio, Donato, Rotulo, Gioacchino Andrea, Deodati, Annalisa, Bianchi, Roberto, Lucignani, Giulia, Longo, Daniela, Valeriani, Massimiliano, Palma, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319257/
https://www.ncbi.nlm.nih.gov/pubmed/35891300
http://dx.doi.org/10.3390/vaccines10071136
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author Santilli, Veronica
Manno, Emma Concetta
Giancotta, Carmela
Rossetti, Chiara
Cotugno, Nicola
Amodio, Donato
Rotulo, Gioacchino Andrea
Deodati, Annalisa
Bianchi, Roberto
Lucignani, Giulia
Longo, Daniela
Valeriani, Massimiliano
Palma, Paolo
author_facet Santilli, Veronica
Manno, Emma Concetta
Giancotta, Carmela
Rossetti, Chiara
Cotugno, Nicola
Amodio, Donato
Rotulo, Gioacchino Andrea
Deodati, Annalisa
Bianchi, Roberto
Lucignani, Giulia
Longo, Daniela
Valeriani, Massimiliano
Palma, Paolo
author_sort Santilli, Veronica
collection PubMed
description The SARS-CoV-2 vaccine roll-out has been successful around the world. However, there are increasing concerns about adverse events. We report two pediatric cases of Multisystem-Inflammatory-Syndrome (MIS-C) with neurological involvement that occurred after SARS-CoV-2 vaccination and unknown recent SARS-CoV-2 infection. Brain magnetic resonance revealed mild-encephalopathy with reversible-splenial-lesion in both cases and complete resolution within 4 weeks. In conclusion, this report aims to describe rare emerging clinical entities that can help pediatricians to make an early diagnosis and to provide appropriate treatment. Multisystem-Inflammatory-Syndromes following COVID-19 vaccination remain rare events. When a history of a recent contact with SARS-CoV-2 is present, a careful evaluation by the clinicians in charge of immunization activities is suggested prior to proceeding with the vaccination.
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spelling pubmed-93192572022-07-27 Two Pediatric Cases of Multisystem Inflammatory Syndrome with Overlapping Neurological Involvement Following SARS-CoV-2 Vaccination and Unknown SARS-CoV2 Infection: The Importance of Pre-Vaccination History Santilli, Veronica Manno, Emma Concetta Giancotta, Carmela Rossetti, Chiara Cotugno, Nicola Amodio, Donato Rotulo, Gioacchino Andrea Deodati, Annalisa Bianchi, Roberto Lucignani, Giulia Longo, Daniela Valeriani, Massimiliano Palma, Paolo Vaccines (Basel) Case Report The SARS-CoV-2 vaccine roll-out has been successful around the world. However, there are increasing concerns about adverse events. We report two pediatric cases of Multisystem-Inflammatory-Syndrome (MIS-C) with neurological involvement that occurred after SARS-CoV-2 vaccination and unknown recent SARS-CoV-2 infection. Brain magnetic resonance revealed mild-encephalopathy with reversible-splenial-lesion in both cases and complete resolution within 4 weeks. In conclusion, this report aims to describe rare emerging clinical entities that can help pediatricians to make an early diagnosis and to provide appropriate treatment. Multisystem-Inflammatory-Syndromes following COVID-19 vaccination remain rare events. When a history of a recent contact with SARS-CoV-2 is present, a careful evaluation by the clinicians in charge of immunization activities is suggested prior to proceeding with the vaccination. MDPI 2022-07-16 /pmc/articles/PMC9319257/ /pubmed/35891300 http://dx.doi.org/10.3390/vaccines10071136 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Santilli, Veronica
Manno, Emma Concetta
Giancotta, Carmela
Rossetti, Chiara
Cotugno, Nicola
Amodio, Donato
Rotulo, Gioacchino Andrea
Deodati, Annalisa
Bianchi, Roberto
Lucignani, Giulia
Longo, Daniela
Valeriani, Massimiliano
Palma, Paolo
Two Pediatric Cases of Multisystem Inflammatory Syndrome with Overlapping Neurological Involvement Following SARS-CoV-2 Vaccination and Unknown SARS-CoV2 Infection: The Importance of Pre-Vaccination History
title Two Pediatric Cases of Multisystem Inflammatory Syndrome with Overlapping Neurological Involvement Following SARS-CoV-2 Vaccination and Unknown SARS-CoV2 Infection: The Importance of Pre-Vaccination History
title_full Two Pediatric Cases of Multisystem Inflammatory Syndrome with Overlapping Neurological Involvement Following SARS-CoV-2 Vaccination and Unknown SARS-CoV2 Infection: The Importance of Pre-Vaccination History
title_fullStr Two Pediatric Cases of Multisystem Inflammatory Syndrome with Overlapping Neurological Involvement Following SARS-CoV-2 Vaccination and Unknown SARS-CoV2 Infection: The Importance of Pre-Vaccination History
title_full_unstemmed Two Pediatric Cases of Multisystem Inflammatory Syndrome with Overlapping Neurological Involvement Following SARS-CoV-2 Vaccination and Unknown SARS-CoV2 Infection: The Importance of Pre-Vaccination History
title_short Two Pediatric Cases of Multisystem Inflammatory Syndrome with Overlapping Neurological Involvement Following SARS-CoV-2 Vaccination and Unknown SARS-CoV2 Infection: The Importance of Pre-Vaccination History
title_sort two pediatric cases of multisystem inflammatory syndrome with overlapping neurological involvement following sars-cov-2 vaccination and unknown sars-cov2 infection: the importance of pre-vaccination history
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319257/
https://www.ncbi.nlm.nih.gov/pubmed/35891300
http://dx.doi.org/10.3390/vaccines10071136
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