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A New Circular Single-Stranded DNA Virus Related with Howler Monkey Associated Porprismacovirus 1 Detected in Children with Acute Gastroenteritis

Putative replication-associated protein (REP) and capsid-like (CAP) proteins are encoded by circular single-stranded DNA viruses (CRESS DNA), which have been found in samples from most eukaryotic groups. However, the details of these viruses’ life cycles and their significance in diseases have yet t...

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Autores principales: Villanova, Fabiola, Milagres, Flávio Augusto de Padua, Brustulin, Rafael, Araújo, Emerson Luiz Lima, Pandey, Ramendra Pati, Raj, V. Samuel, Deng, Xutao, Delwart, Eric, Luchs, Adriana, da Costa, Antonio Charlys, Leal, Élcio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319269/
https://www.ncbi.nlm.nih.gov/pubmed/35891454
http://dx.doi.org/10.3390/v14071472
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author Villanova, Fabiola
Milagres, Flávio Augusto de Padua
Brustulin, Rafael
Araújo, Emerson Luiz Lima
Pandey, Ramendra Pati
Raj, V. Samuel
Deng, Xutao
Delwart, Eric
Luchs, Adriana
da Costa, Antonio Charlys
Leal, Élcio
author_facet Villanova, Fabiola
Milagres, Flávio Augusto de Padua
Brustulin, Rafael
Araújo, Emerson Luiz Lima
Pandey, Ramendra Pati
Raj, V. Samuel
Deng, Xutao
Delwart, Eric
Luchs, Adriana
da Costa, Antonio Charlys
Leal, Élcio
author_sort Villanova, Fabiola
collection PubMed
description Putative replication-associated protein (REP) and capsid-like (CAP) proteins are encoded by circular single-stranded DNA viruses (CRESS DNA), which have been found in samples from most eukaryotic groups. However, the details of these viruses’ life cycles and their significance in diseases have yet to be established. We presented and analyzed two full-length CRESS DNA genomes acquired from two children diagnosed with acute gastroenteritis (GI) in the northeast state of Tocantins, Brazil, using next-generation sequencing and a virus-like filtration approach. Both sequences (named SmaCV3BR08 and SmaCV3BR291) are closely similar to a prior CRESS DNA sequence discovered in the feces of a new world monkey (Alouatta caraya) from the United States in 2009 and termed Howler monkey-associated porprismacovirus 1 (Genbank ID: NC 026317). According to our comparative study, these porprismacovirus genomes deviate by 10% at the nucleotide level. For comparative reasons, the divergence between our sequences (SmaCV3BR08 and SmaCV3BR291) and a porprismacovirus recently identified in a human fecal sample from Peru is 37%. These data suggest that there is a great diversity of porprismacoviruses in South America, perhaps more than two species. In addition, the finding of closely related sequences of porprismacoviruses in humans and native monkeys highlights the zoonotic potential of these viruses.
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spelling pubmed-93192692022-07-27 A New Circular Single-Stranded DNA Virus Related with Howler Monkey Associated Porprismacovirus 1 Detected in Children with Acute Gastroenteritis Villanova, Fabiola Milagres, Flávio Augusto de Padua Brustulin, Rafael Araújo, Emerson Luiz Lima Pandey, Ramendra Pati Raj, V. Samuel Deng, Xutao Delwart, Eric Luchs, Adriana da Costa, Antonio Charlys Leal, Élcio Viruses Article Putative replication-associated protein (REP) and capsid-like (CAP) proteins are encoded by circular single-stranded DNA viruses (CRESS DNA), which have been found in samples from most eukaryotic groups. However, the details of these viruses’ life cycles and their significance in diseases have yet to be established. We presented and analyzed two full-length CRESS DNA genomes acquired from two children diagnosed with acute gastroenteritis (GI) in the northeast state of Tocantins, Brazil, using next-generation sequencing and a virus-like filtration approach. Both sequences (named SmaCV3BR08 and SmaCV3BR291) are closely similar to a prior CRESS DNA sequence discovered in the feces of a new world monkey (Alouatta caraya) from the United States in 2009 and termed Howler monkey-associated porprismacovirus 1 (Genbank ID: NC 026317). According to our comparative study, these porprismacovirus genomes deviate by 10% at the nucleotide level. For comparative reasons, the divergence between our sequences (SmaCV3BR08 and SmaCV3BR291) and a porprismacovirus recently identified in a human fecal sample from Peru is 37%. These data suggest that there is a great diversity of porprismacoviruses in South America, perhaps more than two species. In addition, the finding of closely related sequences of porprismacoviruses in humans and native monkeys highlights the zoonotic potential of these viruses. MDPI 2022-07-04 /pmc/articles/PMC9319269/ /pubmed/35891454 http://dx.doi.org/10.3390/v14071472 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Villanova, Fabiola
Milagres, Flávio Augusto de Padua
Brustulin, Rafael
Araújo, Emerson Luiz Lima
Pandey, Ramendra Pati
Raj, V. Samuel
Deng, Xutao
Delwart, Eric
Luchs, Adriana
da Costa, Antonio Charlys
Leal, Élcio
A New Circular Single-Stranded DNA Virus Related with Howler Monkey Associated Porprismacovirus 1 Detected in Children with Acute Gastroenteritis
title A New Circular Single-Stranded DNA Virus Related with Howler Monkey Associated Porprismacovirus 1 Detected in Children with Acute Gastroenteritis
title_full A New Circular Single-Stranded DNA Virus Related with Howler Monkey Associated Porprismacovirus 1 Detected in Children with Acute Gastroenteritis
title_fullStr A New Circular Single-Stranded DNA Virus Related with Howler Monkey Associated Porprismacovirus 1 Detected in Children with Acute Gastroenteritis
title_full_unstemmed A New Circular Single-Stranded DNA Virus Related with Howler Monkey Associated Porprismacovirus 1 Detected in Children with Acute Gastroenteritis
title_short A New Circular Single-Stranded DNA Virus Related with Howler Monkey Associated Porprismacovirus 1 Detected in Children with Acute Gastroenteritis
title_sort new circular single-stranded dna virus related with howler monkey associated porprismacovirus 1 detected in children with acute gastroenteritis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319269/
https://www.ncbi.nlm.nih.gov/pubmed/35891454
http://dx.doi.org/10.3390/v14071472
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