Cargando…

Taking Advantages of Blood–Brain or Spinal Cord Barrier Alterations or Restoring Them to Optimize Therapy in ALS?

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder that still lacks an efficient therapy. The barriers between the central nervous system (CNS) and the blood represent a major limiting factor to the development of drugs for CNS diseases, including ALS. Alterations of the...

Descripción completa

Detalles Bibliográficos
Autores principales: Alarcan, Hugo, Al Ojaimi, Yara, Lanznaster, Debora, Escoffre, Jean-Michel, Corcia, Philippe, Vourc’h, Patrick, Andres, Christian R., Veyrat-Durebex, Charlotte, Blasco, Hélène
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319288/
https://www.ncbi.nlm.nih.gov/pubmed/35887567
http://dx.doi.org/10.3390/jpm12071071
_version_ 1784755513067569152
author Alarcan, Hugo
Al Ojaimi, Yara
Lanznaster, Debora
Escoffre, Jean-Michel
Corcia, Philippe
Vourc’h, Patrick
Andres, Christian R.
Veyrat-Durebex, Charlotte
Blasco, Hélène
author_facet Alarcan, Hugo
Al Ojaimi, Yara
Lanznaster, Debora
Escoffre, Jean-Michel
Corcia, Philippe
Vourc’h, Patrick
Andres, Christian R.
Veyrat-Durebex, Charlotte
Blasco, Hélène
author_sort Alarcan, Hugo
collection PubMed
description Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder that still lacks an efficient therapy. The barriers between the central nervous system (CNS) and the blood represent a major limiting factor to the development of drugs for CNS diseases, including ALS. Alterations of the blood–brain barrier (BBB) or blood–spinal cord barrier (BSCB) have been reported in this disease but still require further investigations. Interestingly, these alterations might be involved in the complex etiology and pathogenesis of ALS. Moreover, they can have potential consequences on the diffusion of candidate drugs across the brain. The development of techniques to bypass these barriers is continuously evolving and might open the door for personalized medical approaches. Therefore, identifying robust and non-invasive markers of BBB and BSCB alterations can help distinguish different subgroups of patients, such as those in whom barrier disruption can negatively affect the delivery of drugs to their CNS targets. The restoration of CNS barriers using innovative therapies could consequently present the advantage of both alleviating the disease progression and optimizing the safety and efficiency of ALS-specific therapies.
format Online
Article
Text
id pubmed-9319288
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-93192882022-07-27 Taking Advantages of Blood–Brain or Spinal Cord Barrier Alterations or Restoring Them to Optimize Therapy in ALS? Alarcan, Hugo Al Ojaimi, Yara Lanznaster, Debora Escoffre, Jean-Michel Corcia, Philippe Vourc’h, Patrick Andres, Christian R. Veyrat-Durebex, Charlotte Blasco, Hélène J Pers Med Review Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder that still lacks an efficient therapy. The barriers between the central nervous system (CNS) and the blood represent a major limiting factor to the development of drugs for CNS diseases, including ALS. Alterations of the blood–brain barrier (BBB) or blood–spinal cord barrier (BSCB) have been reported in this disease but still require further investigations. Interestingly, these alterations might be involved in the complex etiology and pathogenesis of ALS. Moreover, they can have potential consequences on the diffusion of candidate drugs across the brain. The development of techniques to bypass these barriers is continuously evolving and might open the door for personalized medical approaches. Therefore, identifying robust and non-invasive markers of BBB and BSCB alterations can help distinguish different subgroups of patients, such as those in whom barrier disruption can negatively affect the delivery of drugs to their CNS targets. The restoration of CNS barriers using innovative therapies could consequently present the advantage of both alleviating the disease progression and optimizing the safety and efficiency of ALS-specific therapies. MDPI 2022-06-29 /pmc/articles/PMC9319288/ /pubmed/35887567 http://dx.doi.org/10.3390/jpm12071071 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Alarcan, Hugo
Al Ojaimi, Yara
Lanznaster, Debora
Escoffre, Jean-Michel
Corcia, Philippe
Vourc’h, Patrick
Andres, Christian R.
Veyrat-Durebex, Charlotte
Blasco, Hélène
Taking Advantages of Blood–Brain or Spinal Cord Barrier Alterations or Restoring Them to Optimize Therapy in ALS?
title Taking Advantages of Blood–Brain or Spinal Cord Barrier Alterations or Restoring Them to Optimize Therapy in ALS?
title_full Taking Advantages of Blood–Brain or Spinal Cord Barrier Alterations or Restoring Them to Optimize Therapy in ALS?
title_fullStr Taking Advantages of Blood–Brain or Spinal Cord Barrier Alterations or Restoring Them to Optimize Therapy in ALS?
title_full_unstemmed Taking Advantages of Blood–Brain or Spinal Cord Barrier Alterations or Restoring Them to Optimize Therapy in ALS?
title_short Taking Advantages of Blood–Brain or Spinal Cord Barrier Alterations or Restoring Them to Optimize Therapy in ALS?
title_sort taking advantages of blood–brain or spinal cord barrier alterations or restoring them to optimize therapy in als?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319288/
https://www.ncbi.nlm.nih.gov/pubmed/35887567
http://dx.doi.org/10.3390/jpm12071071
work_keys_str_mv AT alarcanhugo takingadvantagesofbloodbrainorspinalcordbarrieralterationsorrestoringthemtooptimizetherapyinals
AT alojaimiyara takingadvantagesofbloodbrainorspinalcordbarrieralterationsorrestoringthemtooptimizetherapyinals
AT lanznasterdebora takingadvantagesofbloodbrainorspinalcordbarrieralterationsorrestoringthemtooptimizetherapyinals
AT escoffrejeanmichel takingadvantagesofbloodbrainorspinalcordbarrieralterationsorrestoringthemtooptimizetherapyinals
AT corciaphilippe takingadvantagesofbloodbrainorspinalcordbarrieralterationsorrestoringthemtooptimizetherapyinals
AT vourchpatrick takingadvantagesofbloodbrainorspinalcordbarrieralterationsorrestoringthemtooptimizetherapyinals
AT andreschristianr takingadvantagesofbloodbrainorspinalcordbarrieralterationsorrestoringthemtooptimizetherapyinals
AT veyratdurebexcharlotte takingadvantagesofbloodbrainorspinalcordbarrieralterationsorrestoringthemtooptimizetherapyinals
AT blascohelene takingadvantagesofbloodbrainorspinalcordbarrieralterationsorrestoringthemtooptimizetherapyinals