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Towards the Preparation of a Hydrogel from Lyophilisates of the Aloe arborescens Aqueous Extract
Aloe gel is a medicinal raw material with proven pharmacological activity. The health-promoting properties of other species of Aloe upon topical application prompted us to develop a formulation for the topical application of A. arborescence species. As a result of the gel preparation from the aqueou...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319300/ https://www.ncbi.nlm.nih.gov/pubmed/35890383 http://dx.doi.org/10.3390/pharmaceutics14071489 |
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author | Pawłowicz, Kamil Paczkowska-Walendowska, Magdalena Osmałek, Tomasz Cielecka-Piontek, Judyta |
author_facet | Pawłowicz, Kamil Paczkowska-Walendowska, Magdalena Osmałek, Tomasz Cielecka-Piontek, Judyta |
author_sort | Pawłowicz, Kamil |
collection | PubMed |
description | Aloe gel is a medicinal raw material with proven pharmacological activity. The health-promoting properties of other species of Aloe upon topical application prompted us to develop a formulation for the topical application of A. arborescence species. As a result of the gel preparation from the aqueous lyophilized extracts of three-year-old leaves of A. arborescence, no changes in the composition of the content of aloins A and aloenin A were found. The potential to neutralize free radicals was tested using DPPH and CUPRAC techniques, which confirmed the anti-radical activity of the lyophilisate. Screening of the inhibition of enzymes, the hyperactivity of which is associated with adverse changes in the skin of a pro-inflammatory nature, was performed. Importantly, using the PAMPA SKIN model, the possibility of the penetration of selected extract compounds (aloin A and aloenin A) through the skin was proven. Then, two formulations were prepared based on sodium alginate and hydroxypropyl methylcellulose (HPMC) and the hydrogels were characterized (rheological analysis, drug release profiles, permeability, and stability studies). HPMC-based hydrogel was the one with a targeted release of active substances and greater stability. Aloe arborescens hydrogel matrices seem to be a promising treatment strategy for inflammatory surface damage based on “green technology” at the stage of extract preparation and development of the drug form for topical application. |
format | Online Article Text |
id | pubmed-9319300 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93193002022-07-27 Towards the Preparation of a Hydrogel from Lyophilisates of the Aloe arborescens Aqueous Extract Pawłowicz, Kamil Paczkowska-Walendowska, Magdalena Osmałek, Tomasz Cielecka-Piontek, Judyta Pharmaceutics Article Aloe gel is a medicinal raw material with proven pharmacological activity. The health-promoting properties of other species of Aloe upon topical application prompted us to develop a formulation for the topical application of A. arborescence species. As a result of the gel preparation from the aqueous lyophilized extracts of three-year-old leaves of A. arborescence, no changes in the composition of the content of aloins A and aloenin A were found. The potential to neutralize free radicals was tested using DPPH and CUPRAC techniques, which confirmed the anti-radical activity of the lyophilisate. Screening of the inhibition of enzymes, the hyperactivity of which is associated with adverse changes in the skin of a pro-inflammatory nature, was performed. Importantly, using the PAMPA SKIN model, the possibility of the penetration of selected extract compounds (aloin A and aloenin A) through the skin was proven. Then, two formulations were prepared based on sodium alginate and hydroxypropyl methylcellulose (HPMC) and the hydrogels were characterized (rheological analysis, drug release profiles, permeability, and stability studies). HPMC-based hydrogel was the one with a targeted release of active substances and greater stability. Aloe arborescens hydrogel matrices seem to be a promising treatment strategy for inflammatory surface damage based on “green technology” at the stage of extract preparation and development of the drug form for topical application. MDPI 2022-07-18 /pmc/articles/PMC9319300/ /pubmed/35890383 http://dx.doi.org/10.3390/pharmaceutics14071489 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Pawłowicz, Kamil Paczkowska-Walendowska, Magdalena Osmałek, Tomasz Cielecka-Piontek, Judyta Towards the Preparation of a Hydrogel from Lyophilisates of the Aloe arborescens Aqueous Extract |
title | Towards the Preparation of a Hydrogel from Lyophilisates of the Aloe arborescens Aqueous Extract |
title_full | Towards the Preparation of a Hydrogel from Lyophilisates of the Aloe arborescens Aqueous Extract |
title_fullStr | Towards the Preparation of a Hydrogel from Lyophilisates of the Aloe arborescens Aqueous Extract |
title_full_unstemmed | Towards the Preparation of a Hydrogel from Lyophilisates of the Aloe arborescens Aqueous Extract |
title_short | Towards the Preparation of a Hydrogel from Lyophilisates of the Aloe arborescens Aqueous Extract |
title_sort | towards the preparation of a hydrogel from lyophilisates of the aloe arborescens aqueous extract |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319300/ https://www.ncbi.nlm.nih.gov/pubmed/35890383 http://dx.doi.org/10.3390/pharmaceutics14071489 |
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