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Thyroid Diseases and Chronic Rhinosinusitis: A Nested Case–Control Study Using a National Health Screening Cohort

This study aimed to investigate the association between thyroid diseases and chronic sinusitis (CRS) in a matched cohort in a study conducted within the Korean National Health Insurance Service-Health Screening Cohort (2002–2015). A total of 6024 patients with CRS were 1:4-matched for age, sex, hous...

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Autores principales: Choi, Hyo Geun, Kim, Tae Jun, Hong, Sung Kwang, Min, Chanyang, Yoo, Dae Myoung, Kim, Heejin, Lee, Joong Seob
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319341/
https://www.ncbi.nlm.nih.gov/pubmed/35886222
http://dx.doi.org/10.3390/ijerph19148372
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author Choi, Hyo Geun
Kim, Tae Jun
Hong, Sung Kwang
Min, Chanyang
Yoo, Dae Myoung
Kim, Heejin
Lee, Joong Seob
author_facet Choi, Hyo Geun
Kim, Tae Jun
Hong, Sung Kwang
Min, Chanyang
Yoo, Dae Myoung
Kim, Heejin
Lee, Joong Seob
author_sort Choi, Hyo Geun
collection PubMed
description This study aimed to investigate the association between thyroid diseases and chronic sinusitis (CRS) in a matched cohort in a study conducted within the Korean National Health Insurance Service-Health Screening Cohort (2002–2015). A total of 6024 patients with CRS were 1:4-matched for age, sex, household income, and region of residence with 24,096 control participants. Effects of a previous history of thyroid disease, including hypothyroidism, hyperthyroidism, thyroiditis, autoimmune thyroiditis, and Graves’ disease, were investigated using conditional logistic regression. Subgroup analyses were performed in regard to the presence of nasal polyposis. A history of hypothyroidism (2.8% vs. 1.8%), hyperthyroidism (2.0% vs. 1.5%), thyroiditis (1.1% vs. 0.8%), autoimmune thyroiditis (0.4% vs. 0.3%), and Graves’ disease (0.3% vs. 0.2%) was not more prevalent in the CRS group than in the control group according to univariate analysis (all p > 0.05). Hypothyroidism was associated with CRS in the multivariate-adjusted model (odds ratio [OR] 1.25, 95% confidence interval [CI] 1.00–1.57). In the subgroup analyses, thyroid diseases were not statistically significantly associated with CRS after being classified according to the presence or absence of nasal polyps. Additional studies are required to elucidate the relationship between thyroid diseases and CRS, as this may aid in screening and clinical decision making.
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spelling pubmed-93193412022-07-27 Thyroid Diseases and Chronic Rhinosinusitis: A Nested Case–Control Study Using a National Health Screening Cohort Choi, Hyo Geun Kim, Tae Jun Hong, Sung Kwang Min, Chanyang Yoo, Dae Myoung Kim, Heejin Lee, Joong Seob Int J Environ Res Public Health Article This study aimed to investigate the association between thyroid diseases and chronic sinusitis (CRS) in a matched cohort in a study conducted within the Korean National Health Insurance Service-Health Screening Cohort (2002–2015). A total of 6024 patients with CRS were 1:4-matched for age, sex, household income, and region of residence with 24,096 control participants. Effects of a previous history of thyroid disease, including hypothyroidism, hyperthyroidism, thyroiditis, autoimmune thyroiditis, and Graves’ disease, were investigated using conditional logistic regression. Subgroup analyses were performed in regard to the presence of nasal polyposis. A history of hypothyroidism (2.8% vs. 1.8%), hyperthyroidism (2.0% vs. 1.5%), thyroiditis (1.1% vs. 0.8%), autoimmune thyroiditis (0.4% vs. 0.3%), and Graves’ disease (0.3% vs. 0.2%) was not more prevalent in the CRS group than in the control group according to univariate analysis (all p > 0.05). Hypothyroidism was associated with CRS in the multivariate-adjusted model (odds ratio [OR] 1.25, 95% confidence interval [CI] 1.00–1.57). In the subgroup analyses, thyroid diseases were not statistically significantly associated with CRS after being classified according to the presence or absence of nasal polyps. Additional studies are required to elucidate the relationship between thyroid diseases and CRS, as this may aid in screening and clinical decision making. MDPI 2022-07-08 /pmc/articles/PMC9319341/ /pubmed/35886222 http://dx.doi.org/10.3390/ijerph19148372 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Choi, Hyo Geun
Kim, Tae Jun
Hong, Sung Kwang
Min, Chanyang
Yoo, Dae Myoung
Kim, Heejin
Lee, Joong Seob
Thyroid Diseases and Chronic Rhinosinusitis: A Nested Case–Control Study Using a National Health Screening Cohort
title Thyroid Diseases and Chronic Rhinosinusitis: A Nested Case–Control Study Using a National Health Screening Cohort
title_full Thyroid Diseases and Chronic Rhinosinusitis: A Nested Case–Control Study Using a National Health Screening Cohort
title_fullStr Thyroid Diseases and Chronic Rhinosinusitis: A Nested Case–Control Study Using a National Health Screening Cohort
title_full_unstemmed Thyroid Diseases and Chronic Rhinosinusitis: A Nested Case–Control Study Using a National Health Screening Cohort
title_short Thyroid Diseases and Chronic Rhinosinusitis: A Nested Case–Control Study Using a National Health Screening Cohort
title_sort thyroid diseases and chronic rhinosinusitis: a nested case–control study using a national health screening cohort
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319341/
https://www.ncbi.nlm.nih.gov/pubmed/35886222
http://dx.doi.org/10.3390/ijerph19148372
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