Expression of a Functional Mx1 Protein Is Essential for the Ability of RIG-I Agonist Prophylaxis to Provide Potent and Long-Lasting Protection in a Mouse Model of Influenza A Virus Infection

RIG-I is an innate sensor of RNA virus infection and its activation induces interferon-stimulated genes (ISGs). In vitro studies using human cells have demonstrated the ability of synthetic RIG-I agonists (3pRNA) to inhibit IAV replication. However, in mouse models of IAV the effectiveness of 3pRNA...

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Detalles Bibliográficos
Autores principales: Schwab, Lara S. U., Villalón-Letelier, Fernando, Tessema, Melkamu B., Londrigan, Sarah L., Brooks, Andrew G., Hurt, Aeron, Coch, Christoph, Zillinger, Thomas, Hartmann, Gunther, Reading, Patrick C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319350/
https://www.ncbi.nlm.nih.gov/pubmed/35891527
http://dx.doi.org/10.3390/v14071547

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