Synthesis of Functionalized N-(4-Bromophenyl)furan-2-carboxamides via Suzuki-Miyaura Cross-Coupling: Anti-Bacterial Activities against Clinically Isolated Drug Resistant A. baumannii, K. pneumoniae, E. cloacae and MRSA and Its Validation via a Computational Approach

N-(4-bromophenyl)furan-2-carboxamide (3) was synthesized by the reaction furan-2-carbonyl chloride (1) and 4-bromoaniline (2) in the presence of Et(3)N in excellent yields of 94%. The carboxamide (3) was arylated by employing triphenylphosphine palladium as a catalyst and K(3)PO(4) as a base to affo...

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Detalles Bibliográficos
Autores principales: Siddiqa, Ayesha, Zubair, Muhammad, Bilal, Muhammad, Rasool, Nasir, Qamar, Muhammad Usman, Khalid, Aqsa, Ahmad, Gulraiz, Imran, Muhammad, Mahmood, Sajid, Ashraf, Ghulam Abbas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319355/
https://www.ncbi.nlm.nih.gov/pubmed/35890140
http://dx.doi.org/10.3390/ph15070841

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