Cargando…

Human Serum Metabolites as Potential Mediators from Type 2 Diabetes and Obesity to COVID-19 Severity and Susceptibility: Evidence from Mendelian Randomization Study

Obesity, type 2 diabetes (T2D), and severe coronavirus disease 2019 (COVID-19) are closely associated. The aim of this study was to elucidate the casual and mediating relationships of human serum metabolites on the pathways from obesity/T2D to COVID-19 using Mendelian randomization (MR) techniques....

Descripción completa

Detalles Bibliográficos
Autores principales:	Huang, Chuiguo, Shi, Mai, Wu, Hongjiang, Luk, Andrea O. Y., Chan, Juliana C. N., Ma, Ronald C. W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319376/ https://www.ncbi.nlm.nih.gov/pubmed/35888723 http://dx.doi.org/10.3390/metabo12070598

Ejemplares similares

Evaluating the impact of glucokinase activation on risk of cardiovascular disease: a Mendelian randomisation analysis
por: Wang, Ke, et al.
Publicado: (2022)

IDF21-0510 Human Serum Metabolites as Potential Mediators from Obesity to COVID-19: A Network Mendelian Randomization Study
por: Huang, C., et al.
Publicado: (2022)

Shortened Leukocyte Telomere Length Is Associated With Glycemic Progression in Type 2 Diabetes: A Prospective and Mendelian Randomization Analysis
por: Cheng, Feifei, et al.
Publicado: (2022)

The causal effect of physical activity intensity on COVID-19 susceptibility, hospitalization, and severity: Evidence from a mendelian randomization study
por: Zhang, Xing, et al.
Publicado: (2023)

Age- and sex-specific hospital bed-day rates in people with and without type 2 diabetes: A territory-wide population-based cohort study of 1.5 million people in Hong Kong
por: Wu, Hongjiang, et al.
Publicado: (2023)

Carnitine and COVID-19 Susceptibility and Severity: A Mendelian Randomization Study
por: Li, Chunyu, et al.
Publicado: (2021)

COVID-19 susceptibility and severity for dyslipidemia: A mendelian randomization investigation
por: Liang, Yi, et al.
Publicado: (2023)

Genetically Determined Levels of Serum Metabolites and Risk of Neuroticism: A Mendelian Randomization Study
por: Qian, Li, et al.
Publicado: (2020)

Genetically Predicted Levels of Serum Metabolites and Risk of Sarcopenia: A Mendelian Randomization Study
por: Sha, Tingting, et al.
Publicado: (2023)

Causal relationships between short-chain fatty acids and L-isoleucine biosynthesis and susceptibility and severity of COVID-19: Evidence from Mendelian randomization
por: Lv, Wanqiang, et al.
Publicado: (2023)

Cardiometabolic risk factors for COVID-19 susceptibility and severity: A Mendelian randomization analysis
por: Leong, Aaron, et al.
Publicado: (2021)

Gout and susceptibility and severity of COVID-19: A bidirectional Mendelian randomization analysis
por: Peng, Haoxin, et al.
Publicado: (2022)

Weighing Evidence from Mendelian Randomization—Early-Life Obesity as a Causal Factor in Multiple Sclerosis?
por: Ascherio, Alberto, et al.
Publicado: (2016)

Risk Associations of Glycemic Burden and Obesity With Liver Cancer—A 10‐Year Analysis of 15,280 Patients With Type 2 Diabetes
por: Mao, Dandan, et al.
Publicado: (2022)

Serum Albumin and Circulating Metabolites and Risk of Venous Thromboembolism: A Two-Sample Mendelian Randomization Study
por: Liu, Zhengye, et al.
Publicado: (2021)

Circulating metabolites and depression: a bidirectional Mendelian randomization
por: Dong, Yankai, et al.
Publicado: (2023)

Adiposity, metabolites, and colorectal cancer risk: Mendelian randomization study
por: Bull, Caroline J., et al.
Publicado: (2020)

Mendelian randomization study of serum uric acid levels and diabetes risk: evidence from the Dongfeng-Tongji cohort
por: Keerman, Mulatibieke, et al.
Publicado: (2020)

Education and stroke: evidence from epidemiology and Mendelian randomization study
por: Xiuyun, Wen, et al.
Publicado: (2020)

Health Effects of Calcium: Evidence From Mendelian Randomization Studies
por: Chen, Yiheng, et al.
Publicado: (2021)

Causal effects of genetically determined metabolites on cancers included lung, breast, ovarian cancer, and glioma: a Mendelian randomization study
por: Feng, Yi, et al.
Publicado: (2022)

Risk associations of long-term HbA1c variability and obesity on cancer events and cancer-specific death in 15,286 patients with diabetes - A prospective cohort study
por: Mao, Dandan, et al.
Publicado: (2021)

Causal Association Between Serum Thyrotropin and Obesity: A Bidirectional, Mendelian Randomization Study
por: Wang, Xichang, et al.
Publicado: (2021)

Glucose-lowering drug use, glycemic outcomes, and severe hypoglycemia: 18-Year trends in 0·9 million adults with Diabetes in Hong Kong (2002–2019)
por: Yang, Aimin, et al.
Publicado: (2022)

Causal Inference for Genetic Obesity, Cardiometabolic Profile and COVID-19 Susceptibility: A Mendelian Randomization Study
por: Aung, Nay, et al.
Publicado: (2020)

Cancer and COVID-19 Susceptibility and Severity: A Two-Sample Mendelian Randomization and Bioinformatic Analysis
por: Zhang, Yiyin, et al.
Publicado: (2022)

Mendelian randomization reveals no causal relationship between COVID‐19 susceptibility, hospitalization, or severity and epilepsy
por: He, Zihua, et al.
Publicado: (2023)

The causes and consequences of Alzheimer’s disease: phenome-wide evidence from Mendelian randomization
por: Korologou-Linden, Roxanna, et al.
Publicado: (2022)

Mixed evidence for the relationship between periodontitis and Alzheimer’s disease: A bidirectional Mendelian randomization study
por: Sun, Yi-Qian, et al.
Publicado: (2020)

Exploring the causal correlations between 486 serum metabolites and systemic lupus erythematosus: a bidirectional Mendelian randomization study
por: Li, Li, et al.
Publicado: (2023)

Relationship between Serum 25(OH)D and Depression: Causal Evidence from a Bi-Directional Mendelian Randomization Study
por: Mulugeta, Anwar, et al.
Publicado: (2020)

The effect of angiotensin-converting enzyme levels on COVID-19 susceptibility and severity: a Mendelian randomization study
por: Butler-Laporte, Guillaume, et al.
Publicado: (2020)

Periodontal disease increases the host susceptibility to COVID-19 and its severity: a Mendelian randomization study
por: Wang, Yi, et al.
Publicado: (2021)

Genetically Predicted Circulating Concentrations of Micronutrients and COVID-19 Susceptibility and Severity: A Mendelian Randomization Study
por: Daniel, Neil, et al.
Publicado: (2022)

Celiac Disease and the Susceptibility of COVID-19 and the Risk of Severe COVID-19: A Mendelian Randomization Study
por: Li, Jiuling, et al.
Publicado: (2022)

Causal association of epigenetic aging and COVID-19 severity and susceptibility: A bidirectional Mendelian randomization study
por: Xu, Wenchang, et al.
Publicado: (2022)

Visceral adipose tissue and risk of COVID-19 susceptibility, hospitalization, and severity: A Mendelian randomization study
por: Chen, Lu, et al.
Publicado: (2022)

Susceptibility and severity of COVID-19 and risk of psychiatric disorders in European populations: a Mendelian randomization study
por: Xue, Hua, et al.
Publicado: (2023)

Coagulation factors and the incidence of COVID-19 severity: Mendelian randomization analyses and supporting evidence
por: Zhou, Yao, et al.
Publicado: (2021)

Using genetic variants to evaluate the causal effect of serum vitamin D concentration on COVID-19 susceptibility, severity and hospitalization traits: a Mendelian randomization study
por: Cui, Zhiyong, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_lrffj87u1ipm2nsu9ulufg135i