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Does Myasthenia Gravis Affect Long-Term Survival in Thymic Carcinomas? An ESTS Database Analysis

Background: Thymic carcinoma is a rare and highly malignant tumor with a dismal prognosis, which occasionally coexists with myasthenia gravis (MG). This study aims to investigate the MG incidence on a surgical cohort of patients with thymic carcinoma and to explore its influence on long-term surviva...

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Autores principales: Lococo, Filippo, Nachira, Dania, Chiappetta, Marco, Evangelista, Jessica, Falcoz, Pierre Emmanuel, Ruffini, Enrico, Van Schil, Paul, Scarci, Marco, Furàk, Jòzsef, Sollitto, Francesco, Guerrera, Francesco, Spaggiari, Lorenzo, Aigner, Clemens, Evangelia, Liverakou, Billè, Andrea, Moser, Bernhard, Thomas, Pascal Alexandre, Liberman, Moishe, Boubia, Souheil, Campisi, Alessio, Ampollini, Luca, Toker, Alper, Enyed, Attila, Voltolini, Luca, Van Raemdonck, Dirk, Margaritora, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319380/
https://www.ncbi.nlm.nih.gov/pubmed/35885668
http://dx.doi.org/10.3390/diagnostics12071764
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author Lococo, Filippo
Nachira, Dania
Chiappetta, Marco
Evangelista, Jessica
Falcoz, Pierre Emmanuel
Ruffini, Enrico
Van Schil, Paul
Scarci, Marco
Furàk, Jòzsef
Sollitto, Francesco
Guerrera, Francesco
Spaggiari, Lorenzo
Aigner, Clemens
Evangelia, Liverakou
Billè, Andrea
Moser, Bernhard
Thomas, Pascal Alexandre
Liberman, Moishe
Boubia, Souheil
Campisi, Alessio
Ampollini, Luca
Toker, Alper
Enyed, Attila
Voltolini, Luca
Van Raemdonck, Dirk
Margaritora, Stefano
author_facet Lococo, Filippo
Nachira, Dania
Chiappetta, Marco
Evangelista, Jessica
Falcoz, Pierre Emmanuel
Ruffini, Enrico
Van Schil, Paul
Scarci, Marco
Furàk, Jòzsef
Sollitto, Francesco
Guerrera, Francesco
Spaggiari, Lorenzo
Aigner, Clemens
Evangelia, Liverakou
Billè, Andrea
Moser, Bernhard
Thomas, Pascal Alexandre
Liberman, Moishe
Boubia, Souheil
Campisi, Alessio
Ampollini, Luca
Toker, Alper
Enyed, Attila
Voltolini, Luca
Van Raemdonck, Dirk
Margaritora, Stefano
author_sort Lococo, Filippo
collection PubMed
description Background: Thymic carcinoma is a rare and highly malignant tumor with a dismal prognosis, which occasionally coexists with myasthenia gravis (MG). This study aims to investigate the MG incidence on a surgical cohort of patients with thymic carcinoma and to explore its influence on long-term survival. Methods: the prospectively collected data from the ESTS database on thymic epithelial tumors were reviewed. Clinical, pathological, and survival information on thymic carcinoma were analyzed. Results: the analysis was conducted on 203 patients, with an equal gender distribution (96 males and 107 females). MG was detected in 22 (10.8%) patients, more frequently elderly (>60 years, p = 0.048) and male (p = 0.003). Induction therapy was performed in 22 (10.8%) cases. After surgery, 120 (59.1%) patients had a Masaoka stage II–III while complete resection (R0) was achieved in 158 (77.8%). Adjuvant therapy was performed in 68 cases. Mean follow-up was 60 (SD = 14) months. The 3-year, 5-year and 10-year survival rates were 79%, 75% and 63%, respectively. MG did not seem to influence long-term survival (5-year survival in non-MG–TCs 78% vs. 50% in MG–TCs, p = ns) as age < 60 years, female gender, early Masaoka stage, and postoperative radiotherapy did, conversely. Conclusions: myasthenia occurred in about 10% of thymic carcinomas and it did not seem to affect significantly the long-term prognosis in surgically treated thymic carcinoma-patients.
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spelling pubmed-93193802022-07-27 Does Myasthenia Gravis Affect Long-Term Survival in Thymic Carcinomas? An ESTS Database Analysis Lococo, Filippo Nachira, Dania Chiappetta, Marco Evangelista, Jessica Falcoz, Pierre Emmanuel Ruffini, Enrico Van Schil, Paul Scarci, Marco Furàk, Jòzsef Sollitto, Francesco Guerrera, Francesco Spaggiari, Lorenzo Aigner, Clemens Evangelia, Liverakou Billè, Andrea Moser, Bernhard Thomas, Pascal Alexandre Liberman, Moishe Boubia, Souheil Campisi, Alessio Ampollini, Luca Toker, Alper Enyed, Attila Voltolini, Luca Van Raemdonck, Dirk Margaritora, Stefano Diagnostics (Basel) Article Background: Thymic carcinoma is a rare and highly malignant tumor with a dismal prognosis, which occasionally coexists with myasthenia gravis (MG). This study aims to investigate the MG incidence on a surgical cohort of patients with thymic carcinoma and to explore its influence on long-term survival. Methods: the prospectively collected data from the ESTS database on thymic epithelial tumors were reviewed. Clinical, pathological, and survival information on thymic carcinoma were analyzed. Results: the analysis was conducted on 203 patients, with an equal gender distribution (96 males and 107 females). MG was detected in 22 (10.8%) patients, more frequently elderly (>60 years, p = 0.048) and male (p = 0.003). Induction therapy was performed in 22 (10.8%) cases. After surgery, 120 (59.1%) patients had a Masaoka stage II–III while complete resection (R0) was achieved in 158 (77.8%). Adjuvant therapy was performed in 68 cases. Mean follow-up was 60 (SD = 14) months. The 3-year, 5-year and 10-year survival rates were 79%, 75% and 63%, respectively. MG did not seem to influence long-term survival (5-year survival in non-MG–TCs 78% vs. 50% in MG–TCs, p = ns) as age < 60 years, female gender, early Masaoka stage, and postoperative radiotherapy did, conversely. Conclusions: myasthenia occurred in about 10% of thymic carcinomas and it did not seem to affect significantly the long-term prognosis in surgically treated thymic carcinoma-patients. MDPI 2022-07-21 /pmc/articles/PMC9319380/ /pubmed/35885668 http://dx.doi.org/10.3390/diagnostics12071764 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lococo, Filippo
Nachira, Dania
Chiappetta, Marco
Evangelista, Jessica
Falcoz, Pierre Emmanuel
Ruffini, Enrico
Van Schil, Paul
Scarci, Marco
Furàk, Jòzsef
Sollitto, Francesco
Guerrera, Francesco
Spaggiari, Lorenzo
Aigner, Clemens
Evangelia, Liverakou
Billè, Andrea
Moser, Bernhard
Thomas, Pascal Alexandre
Liberman, Moishe
Boubia, Souheil
Campisi, Alessio
Ampollini, Luca
Toker, Alper
Enyed, Attila
Voltolini, Luca
Van Raemdonck, Dirk
Margaritora, Stefano
Does Myasthenia Gravis Affect Long-Term Survival in Thymic Carcinomas? An ESTS Database Analysis
title Does Myasthenia Gravis Affect Long-Term Survival in Thymic Carcinomas? An ESTS Database Analysis
title_full Does Myasthenia Gravis Affect Long-Term Survival in Thymic Carcinomas? An ESTS Database Analysis
title_fullStr Does Myasthenia Gravis Affect Long-Term Survival in Thymic Carcinomas? An ESTS Database Analysis
title_full_unstemmed Does Myasthenia Gravis Affect Long-Term Survival in Thymic Carcinomas? An ESTS Database Analysis
title_short Does Myasthenia Gravis Affect Long-Term Survival in Thymic Carcinomas? An ESTS Database Analysis
title_sort does myasthenia gravis affect long-term survival in thymic carcinomas? an ests database analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319380/
https://www.ncbi.nlm.nih.gov/pubmed/35885668
http://dx.doi.org/10.3390/diagnostics12071764
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