Cargando…
Does Myasthenia Gravis Affect Long-Term Survival in Thymic Carcinomas? An ESTS Database Analysis
Background: Thymic carcinoma is a rare and highly malignant tumor with a dismal prognosis, which occasionally coexists with myasthenia gravis (MG). This study aims to investigate the MG incidence on a surgical cohort of patients with thymic carcinoma and to explore its influence on long-term surviva...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319380/ https://www.ncbi.nlm.nih.gov/pubmed/35885668 http://dx.doi.org/10.3390/diagnostics12071764 |
_version_ | 1784755535061450752 |
---|---|
author | Lococo, Filippo Nachira, Dania Chiappetta, Marco Evangelista, Jessica Falcoz, Pierre Emmanuel Ruffini, Enrico Van Schil, Paul Scarci, Marco Furàk, Jòzsef Sollitto, Francesco Guerrera, Francesco Spaggiari, Lorenzo Aigner, Clemens Evangelia, Liverakou Billè, Andrea Moser, Bernhard Thomas, Pascal Alexandre Liberman, Moishe Boubia, Souheil Campisi, Alessio Ampollini, Luca Toker, Alper Enyed, Attila Voltolini, Luca Van Raemdonck, Dirk Margaritora, Stefano |
author_facet | Lococo, Filippo Nachira, Dania Chiappetta, Marco Evangelista, Jessica Falcoz, Pierre Emmanuel Ruffini, Enrico Van Schil, Paul Scarci, Marco Furàk, Jòzsef Sollitto, Francesco Guerrera, Francesco Spaggiari, Lorenzo Aigner, Clemens Evangelia, Liverakou Billè, Andrea Moser, Bernhard Thomas, Pascal Alexandre Liberman, Moishe Boubia, Souheil Campisi, Alessio Ampollini, Luca Toker, Alper Enyed, Attila Voltolini, Luca Van Raemdonck, Dirk Margaritora, Stefano |
author_sort | Lococo, Filippo |
collection | PubMed |
description | Background: Thymic carcinoma is a rare and highly malignant tumor with a dismal prognosis, which occasionally coexists with myasthenia gravis (MG). This study aims to investigate the MG incidence on a surgical cohort of patients with thymic carcinoma and to explore its influence on long-term survival. Methods: the prospectively collected data from the ESTS database on thymic epithelial tumors were reviewed. Clinical, pathological, and survival information on thymic carcinoma were analyzed. Results: the analysis was conducted on 203 patients, with an equal gender distribution (96 males and 107 females). MG was detected in 22 (10.8%) patients, more frequently elderly (>60 years, p = 0.048) and male (p = 0.003). Induction therapy was performed in 22 (10.8%) cases. After surgery, 120 (59.1%) patients had a Masaoka stage II–III while complete resection (R0) was achieved in 158 (77.8%). Adjuvant therapy was performed in 68 cases. Mean follow-up was 60 (SD = 14) months. The 3-year, 5-year and 10-year survival rates were 79%, 75% and 63%, respectively. MG did not seem to influence long-term survival (5-year survival in non-MG–TCs 78% vs. 50% in MG–TCs, p = ns) as age < 60 years, female gender, early Masaoka stage, and postoperative radiotherapy did, conversely. Conclusions: myasthenia occurred in about 10% of thymic carcinomas and it did not seem to affect significantly the long-term prognosis in surgically treated thymic carcinoma-patients. |
format | Online Article Text |
id | pubmed-9319380 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93193802022-07-27 Does Myasthenia Gravis Affect Long-Term Survival in Thymic Carcinomas? An ESTS Database Analysis Lococo, Filippo Nachira, Dania Chiappetta, Marco Evangelista, Jessica Falcoz, Pierre Emmanuel Ruffini, Enrico Van Schil, Paul Scarci, Marco Furàk, Jòzsef Sollitto, Francesco Guerrera, Francesco Spaggiari, Lorenzo Aigner, Clemens Evangelia, Liverakou Billè, Andrea Moser, Bernhard Thomas, Pascal Alexandre Liberman, Moishe Boubia, Souheil Campisi, Alessio Ampollini, Luca Toker, Alper Enyed, Attila Voltolini, Luca Van Raemdonck, Dirk Margaritora, Stefano Diagnostics (Basel) Article Background: Thymic carcinoma is a rare and highly malignant tumor with a dismal prognosis, which occasionally coexists with myasthenia gravis (MG). This study aims to investigate the MG incidence on a surgical cohort of patients with thymic carcinoma and to explore its influence on long-term survival. Methods: the prospectively collected data from the ESTS database on thymic epithelial tumors were reviewed. Clinical, pathological, and survival information on thymic carcinoma were analyzed. Results: the analysis was conducted on 203 patients, with an equal gender distribution (96 males and 107 females). MG was detected in 22 (10.8%) patients, more frequently elderly (>60 years, p = 0.048) and male (p = 0.003). Induction therapy was performed in 22 (10.8%) cases. After surgery, 120 (59.1%) patients had a Masaoka stage II–III while complete resection (R0) was achieved in 158 (77.8%). Adjuvant therapy was performed in 68 cases. Mean follow-up was 60 (SD = 14) months. The 3-year, 5-year and 10-year survival rates were 79%, 75% and 63%, respectively. MG did not seem to influence long-term survival (5-year survival in non-MG–TCs 78% vs. 50% in MG–TCs, p = ns) as age < 60 years, female gender, early Masaoka stage, and postoperative radiotherapy did, conversely. Conclusions: myasthenia occurred in about 10% of thymic carcinomas and it did not seem to affect significantly the long-term prognosis in surgically treated thymic carcinoma-patients. MDPI 2022-07-21 /pmc/articles/PMC9319380/ /pubmed/35885668 http://dx.doi.org/10.3390/diagnostics12071764 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Lococo, Filippo Nachira, Dania Chiappetta, Marco Evangelista, Jessica Falcoz, Pierre Emmanuel Ruffini, Enrico Van Schil, Paul Scarci, Marco Furàk, Jòzsef Sollitto, Francesco Guerrera, Francesco Spaggiari, Lorenzo Aigner, Clemens Evangelia, Liverakou Billè, Andrea Moser, Bernhard Thomas, Pascal Alexandre Liberman, Moishe Boubia, Souheil Campisi, Alessio Ampollini, Luca Toker, Alper Enyed, Attila Voltolini, Luca Van Raemdonck, Dirk Margaritora, Stefano Does Myasthenia Gravis Affect Long-Term Survival in Thymic Carcinomas? An ESTS Database Analysis |
title | Does Myasthenia Gravis Affect Long-Term Survival in Thymic Carcinomas? An ESTS Database Analysis |
title_full | Does Myasthenia Gravis Affect Long-Term Survival in Thymic Carcinomas? An ESTS Database Analysis |
title_fullStr | Does Myasthenia Gravis Affect Long-Term Survival in Thymic Carcinomas? An ESTS Database Analysis |
title_full_unstemmed | Does Myasthenia Gravis Affect Long-Term Survival in Thymic Carcinomas? An ESTS Database Analysis |
title_short | Does Myasthenia Gravis Affect Long-Term Survival in Thymic Carcinomas? An ESTS Database Analysis |
title_sort | does myasthenia gravis affect long-term survival in thymic carcinomas? an ests database analysis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319380/ https://www.ncbi.nlm.nih.gov/pubmed/35885668 http://dx.doi.org/10.3390/diagnostics12071764 |
work_keys_str_mv | AT lococofilippo doesmyastheniagravisaffectlongtermsurvivalinthymiccarcinomasanestsdatabaseanalysis AT nachiradania doesmyastheniagravisaffectlongtermsurvivalinthymiccarcinomasanestsdatabaseanalysis AT chiappettamarco doesmyastheniagravisaffectlongtermsurvivalinthymiccarcinomasanestsdatabaseanalysis AT evangelistajessica doesmyastheniagravisaffectlongtermsurvivalinthymiccarcinomasanestsdatabaseanalysis AT falcozpierreemmanuel doesmyastheniagravisaffectlongtermsurvivalinthymiccarcinomasanestsdatabaseanalysis AT ruffinienrico doesmyastheniagravisaffectlongtermsurvivalinthymiccarcinomasanestsdatabaseanalysis AT vanschilpaul doesmyastheniagravisaffectlongtermsurvivalinthymiccarcinomasanestsdatabaseanalysis AT scarcimarco doesmyastheniagravisaffectlongtermsurvivalinthymiccarcinomasanestsdatabaseanalysis AT furakjozsef doesmyastheniagravisaffectlongtermsurvivalinthymiccarcinomasanestsdatabaseanalysis AT sollittofrancesco doesmyastheniagravisaffectlongtermsurvivalinthymiccarcinomasanestsdatabaseanalysis AT guerrerafrancesco doesmyastheniagravisaffectlongtermsurvivalinthymiccarcinomasanestsdatabaseanalysis AT spaggiarilorenzo doesmyastheniagravisaffectlongtermsurvivalinthymiccarcinomasanestsdatabaseanalysis AT aignerclemens doesmyastheniagravisaffectlongtermsurvivalinthymiccarcinomasanestsdatabaseanalysis AT evangelialiverakou doesmyastheniagravisaffectlongtermsurvivalinthymiccarcinomasanestsdatabaseanalysis AT billeandrea doesmyastheniagravisaffectlongtermsurvivalinthymiccarcinomasanestsdatabaseanalysis AT moserbernhard doesmyastheniagravisaffectlongtermsurvivalinthymiccarcinomasanestsdatabaseanalysis AT thomaspascalalexandre doesmyastheniagravisaffectlongtermsurvivalinthymiccarcinomasanestsdatabaseanalysis AT libermanmoishe doesmyastheniagravisaffectlongtermsurvivalinthymiccarcinomasanestsdatabaseanalysis AT boubiasouheil doesmyastheniagravisaffectlongtermsurvivalinthymiccarcinomasanestsdatabaseanalysis AT campisialessio doesmyastheniagravisaffectlongtermsurvivalinthymiccarcinomasanestsdatabaseanalysis AT ampolliniluca doesmyastheniagravisaffectlongtermsurvivalinthymiccarcinomasanestsdatabaseanalysis AT tokeralper doesmyastheniagravisaffectlongtermsurvivalinthymiccarcinomasanestsdatabaseanalysis AT enyedattila doesmyastheniagravisaffectlongtermsurvivalinthymiccarcinomasanestsdatabaseanalysis AT voltoliniluca doesmyastheniagravisaffectlongtermsurvivalinthymiccarcinomasanestsdatabaseanalysis AT vanraemdonckdirk doesmyastheniagravisaffectlongtermsurvivalinthymiccarcinomasanestsdatabaseanalysis AT margaritorastefano doesmyastheniagravisaffectlongtermsurvivalinthymiccarcinomasanestsdatabaseanalysis AT doesmyastheniagravisaffectlongtermsurvivalinthymiccarcinomasanestsdatabaseanalysis |