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Gut Microbiota Manipulation in Irritable Bowel Syndrome

Increased knowledge suggests that disturbed gut microbiota, termed dysbiosis, might promote the development of irritable bowel syndrome (IBS) symptoms. Accordingly, gut microbiota manipulation has evolved in the last decade as a novel treatment strategy in order to improve IBS symptoms. In using dif...

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Detalles Bibliográficos
Autor principal: Mazzawi, Tarek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319495/
https://www.ncbi.nlm.nih.gov/pubmed/35889051
http://dx.doi.org/10.3390/microorganisms10071332
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author Mazzawi, Tarek
author_facet Mazzawi, Tarek
author_sort Mazzawi, Tarek
collection PubMed
description Increased knowledge suggests that disturbed gut microbiota, termed dysbiosis, might promote the development of irritable bowel syndrome (IBS) symptoms. Accordingly, gut microbiota manipulation has evolved in the last decade as a novel treatment strategy in order to improve IBS symptoms. In using different approaches, dietary management stands first in line, including dietary fiber supplements, prebiotics, and probiotics that are shown to change the composition of gut microbiota, fecal short-chain fatty acids and enteroendocrine cells densities and improve IBS symptoms. However, the exact mixture of beneficial bacteria for each individual remains to be identified. Prescribing nonabsorbable antibiotics still needs confirmation, although using rifaximin has been approved for diarrhea-predominant IBS. Fecal microbiota transplantation (FMT) has recently gained a lot of attention, and five out of seven placebo-controlled trials investigating FMT in IBS obtain promising results regarding symptom reduction and gut microbiota manipulation. However, more data, including larger cohorts and studying long-term effects, are needed before FMT can be regarded as a treatment for IBS in clinical practice.
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spelling pubmed-93194952022-07-27 Gut Microbiota Manipulation in Irritable Bowel Syndrome Mazzawi, Tarek Microorganisms Review Increased knowledge suggests that disturbed gut microbiota, termed dysbiosis, might promote the development of irritable bowel syndrome (IBS) symptoms. Accordingly, gut microbiota manipulation has evolved in the last decade as a novel treatment strategy in order to improve IBS symptoms. In using different approaches, dietary management stands first in line, including dietary fiber supplements, prebiotics, and probiotics that are shown to change the composition of gut microbiota, fecal short-chain fatty acids and enteroendocrine cells densities and improve IBS symptoms. However, the exact mixture of beneficial bacteria for each individual remains to be identified. Prescribing nonabsorbable antibiotics still needs confirmation, although using rifaximin has been approved for diarrhea-predominant IBS. Fecal microbiota transplantation (FMT) has recently gained a lot of attention, and five out of seven placebo-controlled trials investigating FMT in IBS obtain promising results regarding symptom reduction and gut microbiota manipulation. However, more data, including larger cohorts and studying long-term effects, are needed before FMT can be regarded as a treatment for IBS in clinical practice. MDPI 2022-06-30 /pmc/articles/PMC9319495/ /pubmed/35889051 http://dx.doi.org/10.3390/microorganisms10071332 Text en © 2022 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mazzawi, Tarek
Gut Microbiota Manipulation in Irritable Bowel Syndrome
title Gut Microbiota Manipulation in Irritable Bowel Syndrome
title_full Gut Microbiota Manipulation in Irritable Bowel Syndrome
title_fullStr Gut Microbiota Manipulation in Irritable Bowel Syndrome
title_full_unstemmed Gut Microbiota Manipulation in Irritable Bowel Syndrome
title_short Gut Microbiota Manipulation in Irritable Bowel Syndrome
title_sort gut microbiota manipulation in irritable bowel syndrome
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319495/
https://www.ncbi.nlm.nih.gov/pubmed/35889051
http://dx.doi.org/10.3390/microorganisms10071332
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