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Correlations of Obstructive Sleep Apnea Syndrome and Daytime Sleepiness with the Risk of Car Accidents in Adult Working Population: A Systematic Review and Meta-Analysis with a Gender-Based Approach

Obstructive sleep apnea syndrome (OSAS) is an under-recognized clinical condition and is correlated with sleepiness and impaired cognitive function. Objectives: The primary aim of this systematic review, developed within the Sleep@OSA project, was to determine the correlations of obstructive sleep a...

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Autores principales: Luzzi, Valeria, Mazur, Marta, Guaragna, Mariana, Di Carlo, Gabriele, Cotticelli, Luisa, Magliulo, Giuseppe, Marasca, Beatrice, Pirro, Valentina, Di Giorgio, Gianni, Ndokaj, Artnora, Pasqualetti, Patrizio, Simonelli, Ilaria, Martini, Agnese, Pietrafesa, Emma, Polimeni, Antonella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319534/
https://www.ncbi.nlm.nih.gov/pubmed/35887735
http://dx.doi.org/10.3390/jcm11143971
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author Luzzi, Valeria
Mazur, Marta
Guaragna, Mariana
Di Carlo, Gabriele
Cotticelli, Luisa
Magliulo, Giuseppe
Marasca, Beatrice
Pirro, Valentina
Di Giorgio, Gianni
Ndokaj, Artnora
Pasqualetti, Patrizio
Simonelli, Ilaria
Martini, Agnese
Pietrafesa, Emma
Polimeni, Antonella
author_facet Luzzi, Valeria
Mazur, Marta
Guaragna, Mariana
Di Carlo, Gabriele
Cotticelli, Luisa
Magliulo, Giuseppe
Marasca, Beatrice
Pirro, Valentina
Di Giorgio, Gianni
Ndokaj, Artnora
Pasqualetti, Patrizio
Simonelli, Ilaria
Martini, Agnese
Pietrafesa, Emma
Polimeni, Antonella
author_sort Luzzi, Valeria
collection PubMed
description Obstructive sleep apnea syndrome (OSAS) is an under-recognized clinical condition and is correlated with sleepiness and impaired cognitive function. Objectives: The primary aim of this systematic review, developed within the Sleep@OSA project, was to determine the correlations of obstructive sleep apnea syndrome, daytime sleepiness and sleep-disordered breathing with the risk of car accidents in adult working populations; a secondary aim was to analyze the epidemiologic data with a gender-based approach to identify differences between women and men in the data and in associated risk factors. Methods: Clinical trials and studies reporting data on the frequency of car accidents involving adult working population with daytime sleepiness and/or OSAS compared with a control group of participants were included. Literature searches of free text and MeSH terms were performed using PubMed, Google Scholar, the Cochrane Library and Scopus from 1952 to 3 May 2021. Results and Conclusions: The search strategy identified 2138 potential articles. Of these, 49 papers were included in the qualitative synthesis, and 30 were included in the meta-analysis. Compared with controls, the odds of car accidents were found to be more than double in subjects with OSAS (OR = 2.36; 95% CI 1.92–2.91; p < 0.001), with a similar risk between commercial motor vehicle drivers (OR = 2.80; 95% CI 1.82–4.31) and noncommercial motor vehicle drivers (OR = 2.32; 95% CI 1.84–2.34). No significant correlation was found between sleepiness and car crashes, but subjects with sleep-disordered breathing were at increased risk of car accidents (OR = 1.81; 95% CI 1.42–2.31; p < 0.001). To our surprise, although epidemiological studies on the risk of road accidents in the adult population with OSAS and daytime sleepiness are currently very abundant, specific data on the female population are not available.
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spelling pubmed-93195342022-07-27 Correlations of Obstructive Sleep Apnea Syndrome and Daytime Sleepiness with the Risk of Car Accidents in Adult Working Population: A Systematic Review and Meta-Analysis with a Gender-Based Approach Luzzi, Valeria Mazur, Marta Guaragna, Mariana Di Carlo, Gabriele Cotticelli, Luisa Magliulo, Giuseppe Marasca, Beatrice Pirro, Valentina Di Giorgio, Gianni Ndokaj, Artnora Pasqualetti, Patrizio Simonelli, Ilaria Martini, Agnese Pietrafesa, Emma Polimeni, Antonella J Clin Med Systematic Review Obstructive sleep apnea syndrome (OSAS) is an under-recognized clinical condition and is correlated with sleepiness and impaired cognitive function. Objectives: The primary aim of this systematic review, developed within the Sleep@OSA project, was to determine the correlations of obstructive sleep apnea syndrome, daytime sleepiness and sleep-disordered breathing with the risk of car accidents in adult working populations; a secondary aim was to analyze the epidemiologic data with a gender-based approach to identify differences between women and men in the data and in associated risk factors. Methods: Clinical trials and studies reporting data on the frequency of car accidents involving adult working population with daytime sleepiness and/or OSAS compared with a control group of participants were included. Literature searches of free text and MeSH terms were performed using PubMed, Google Scholar, the Cochrane Library and Scopus from 1952 to 3 May 2021. Results and Conclusions: The search strategy identified 2138 potential articles. Of these, 49 papers were included in the qualitative synthesis, and 30 were included in the meta-analysis. Compared with controls, the odds of car accidents were found to be more than double in subjects with OSAS (OR = 2.36; 95% CI 1.92–2.91; p < 0.001), with a similar risk between commercial motor vehicle drivers (OR = 2.80; 95% CI 1.82–4.31) and noncommercial motor vehicle drivers (OR = 2.32; 95% CI 1.84–2.34). No significant correlation was found between sleepiness and car crashes, but subjects with sleep-disordered breathing were at increased risk of car accidents (OR = 1.81; 95% CI 1.42–2.31; p < 0.001). To our surprise, although epidemiological studies on the risk of road accidents in the adult population with OSAS and daytime sleepiness are currently very abundant, specific data on the female population are not available. MDPI 2022-07-08 /pmc/articles/PMC9319534/ /pubmed/35887735 http://dx.doi.org/10.3390/jcm11143971 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Luzzi, Valeria
Mazur, Marta
Guaragna, Mariana
Di Carlo, Gabriele
Cotticelli, Luisa
Magliulo, Giuseppe
Marasca, Beatrice
Pirro, Valentina
Di Giorgio, Gianni
Ndokaj, Artnora
Pasqualetti, Patrizio
Simonelli, Ilaria
Martini, Agnese
Pietrafesa, Emma
Polimeni, Antonella
Correlations of Obstructive Sleep Apnea Syndrome and Daytime Sleepiness with the Risk of Car Accidents in Adult Working Population: A Systematic Review and Meta-Analysis with a Gender-Based Approach
title Correlations of Obstructive Sleep Apnea Syndrome and Daytime Sleepiness with the Risk of Car Accidents in Adult Working Population: A Systematic Review and Meta-Analysis with a Gender-Based Approach
title_full Correlations of Obstructive Sleep Apnea Syndrome and Daytime Sleepiness with the Risk of Car Accidents in Adult Working Population: A Systematic Review and Meta-Analysis with a Gender-Based Approach
title_fullStr Correlations of Obstructive Sleep Apnea Syndrome and Daytime Sleepiness with the Risk of Car Accidents in Adult Working Population: A Systematic Review and Meta-Analysis with a Gender-Based Approach
title_full_unstemmed Correlations of Obstructive Sleep Apnea Syndrome and Daytime Sleepiness with the Risk of Car Accidents in Adult Working Population: A Systematic Review and Meta-Analysis with a Gender-Based Approach
title_short Correlations of Obstructive Sleep Apnea Syndrome and Daytime Sleepiness with the Risk of Car Accidents in Adult Working Population: A Systematic Review and Meta-Analysis with a Gender-Based Approach
title_sort correlations of obstructive sleep apnea syndrome and daytime sleepiness with the risk of car accidents in adult working population: a systematic review and meta-analysis with a gender-based approach
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319534/
https://www.ncbi.nlm.nih.gov/pubmed/35887735
http://dx.doi.org/10.3390/jcm11143971
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