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Prognostic Value of Systemic Immune-Inflammation Index among Critically Ill Patients with Acute Kidney Injury: A Retrospective Cohort Study

Inflammation plays a significant role in the occurrence and development of acute kidney injury (AKI). Evidence regarding the prognostic effect of the systemic immune-inflammation index (SII) in critically ill patients with AKI is scarce. The aim of this study was to assess the association between SI...

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Autores principales: Jia, Lan, Li, Chen, Bi, Xueqing, Wei, Fang, Meng, Jia, Sun, Guijiang, Yu, Haibo, Dong, Hongye, Li, Bo, Cao, Yueqi, Wang, Lihua, Jiang, Aili
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319546/
https://www.ncbi.nlm.nih.gov/pubmed/35887742
http://dx.doi.org/10.3390/jcm11143978
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author Jia, Lan
Li, Chen
Bi, Xueqing
Wei, Fang
Meng, Jia
Sun, Guijiang
Yu, Haibo
Dong, Hongye
Li, Bo
Cao, Yueqi
Wang, Lihua
Jiang, Aili
author_facet Jia, Lan
Li, Chen
Bi, Xueqing
Wei, Fang
Meng, Jia
Sun, Guijiang
Yu, Haibo
Dong, Hongye
Li, Bo
Cao, Yueqi
Wang, Lihua
Jiang, Aili
author_sort Jia, Lan
collection PubMed
description Inflammation plays a significant role in the occurrence and development of acute kidney injury (AKI). Evidence regarding the prognostic effect of the systemic immune-inflammation index (SII) in critically ill patients with AKI is scarce. The aim of this study was to assess the association between SII and all-cause mortality in these patients. Detailed clinical data were extracted from the Medical Information Mart for Intensive Care Database (MIMIC)-IV. The primary outcome was set as the in-hospital mortality. A total of 10,764 AKI patients were enrolled in this study. The restricted cubic splines analyses showed a J-shaped curve between SII and the risk of in-hospital and ICU mortality. After adjusting for relevant confounders, multivariate Cox regression analysis showed that both lower and higher SII levels were associated with an elevated risk of in-hospital all-cause mortality. A similar trend was observed for ICU mortality. In summary, we found that the SII was associated in a J-shaped pattern with all-cause mortality among critically ill patients with AKI. SII appears to be have potential applications in the clinical setting as a novel and easily accessible biomarker for predicting the prognosis of AKI patients.
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spelling pubmed-93195462022-07-27 Prognostic Value of Systemic Immune-Inflammation Index among Critically Ill Patients with Acute Kidney Injury: A Retrospective Cohort Study Jia, Lan Li, Chen Bi, Xueqing Wei, Fang Meng, Jia Sun, Guijiang Yu, Haibo Dong, Hongye Li, Bo Cao, Yueqi Wang, Lihua Jiang, Aili J Clin Med Article Inflammation plays a significant role in the occurrence and development of acute kidney injury (AKI). Evidence regarding the prognostic effect of the systemic immune-inflammation index (SII) in critically ill patients with AKI is scarce. The aim of this study was to assess the association between SII and all-cause mortality in these patients. Detailed clinical data were extracted from the Medical Information Mart for Intensive Care Database (MIMIC)-IV. The primary outcome was set as the in-hospital mortality. A total of 10,764 AKI patients were enrolled in this study. The restricted cubic splines analyses showed a J-shaped curve between SII and the risk of in-hospital and ICU mortality. After adjusting for relevant confounders, multivariate Cox regression analysis showed that both lower and higher SII levels were associated with an elevated risk of in-hospital all-cause mortality. A similar trend was observed for ICU mortality. In summary, we found that the SII was associated in a J-shaped pattern with all-cause mortality among critically ill patients with AKI. SII appears to be have potential applications in the clinical setting as a novel and easily accessible biomarker for predicting the prognosis of AKI patients. MDPI 2022-07-08 /pmc/articles/PMC9319546/ /pubmed/35887742 http://dx.doi.org/10.3390/jcm11143978 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jia, Lan
Li, Chen
Bi, Xueqing
Wei, Fang
Meng, Jia
Sun, Guijiang
Yu, Haibo
Dong, Hongye
Li, Bo
Cao, Yueqi
Wang, Lihua
Jiang, Aili
Prognostic Value of Systemic Immune-Inflammation Index among Critically Ill Patients with Acute Kidney Injury: A Retrospective Cohort Study
title Prognostic Value of Systemic Immune-Inflammation Index among Critically Ill Patients with Acute Kidney Injury: A Retrospective Cohort Study
title_full Prognostic Value of Systemic Immune-Inflammation Index among Critically Ill Patients with Acute Kidney Injury: A Retrospective Cohort Study
title_fullStr Prognostic Value of Systemic Immune-Inflammation Index among Critically Ill Patients with Acute Kidney Injury: A Retrospective Cohort Study
title_full_unstemmed Prognostic Value of Systemic Immune-Inflammation Index among Critically Ill Patients with Acute Kidney Injury: A Retrospective Cohort Study
title_short Prognostic Value of Systemic Immune-Inflammation Index among Critically Ill Patients with Acute Kidney Injury: A Retrospective Cohort Study
title_sort prognostic value of systemic immune-inflammation index among critically ill patients with acute kidney injury: a retrospective cohort study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319546/
https://www.ncbi.nlm.nih.gov/pubmed/35887742
http://dx.doi.org/10.3390/jcm11143978
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