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Honeys as Possible Sources of Cholinesterase Inhibitors
Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterised by low levels of the neurotransmitter (acetylcholine), oxidative stress, and inflammation of the central nervous system. The only currently available form of treatment entails the administration of AChE/BChE (acetylcho...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319579/ https://www.ncbi.nlm.nih.gov/pubmed/35889933 http://dx.doi.org/10.3390/nu14142969 |
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author | Szwajgier, Dominik Baranowska-Wójcik, Ewa Winiarska-Mieczan, Anna Gajowniczek-Ałasa, Dorota |
author_facet | Szwajgier, Dominik Baranowska-Wójcik, Ewa Winiarska-Mieczan, Anna Gajowniczek-Ałasa, Dorota |
author_sort | Szwajgier, Dominik |
collection | PubMed |
description | Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterised by low levels of the neurotransmitter (acetylcholine), oxidative stress, and inflammation of the central nervous system. The only currently available form of treatment entails the administration of AChE/BChE (acetylcholinesterase/butyrylcholinesterase) inhibitors to patients diagnosed with the disease. However, AD prevention is possible by administering the correct inhibitors with food. The aim of this study was to examine 19 types of honey in terms of their contents of cholinesterase inhibitors. The inhibition of AChE and BChE relative to the respective honey samples was evaluated using Ellman’s colorimetric method, including the “false-positive” effect. The highest potential for AChE inhibition was observed in the case of thyme honey (21.17% inhibition), while goldenrod honey showed the highest capacity for BChE inhibition (33.89%). Our study showed that honeys may provide a rich source of cholinesterase inhibitors and, in this way, play a significant role in AD. |
format | Online Article Text |
id | pubmed-9319579 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93195792022-07-27 Honeys as Possible Sources of Cholinesterase Inhibitors Szwajgier, Dominik Baranowska-Wójcik, Ewa Winiarska-Mieczan, Anna Gajowniczek-Ałasa, Dorota Nutrients Article Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterised by low levels of the neurotransmitter (acetylcholine), oxidative stress, and inflammation of the central nervous system. The only currently available form of treatment entails the administration of AChE/BChE (acetylcholinesterase/butyrylcholinesterase) inhibitors to patients diagnosed with the disease. However, AD prevention is possible by administering the correct inhibitors with food. The aim of this study was to examine 19 types of honey in terms of their contents of cholinesterase inhibitors. The inhibition of AChE and BChE relative to the respective honey samples was evaluated using Ellman’s colorimetric method, including the “false-positive” effect. The highest potential for AChE inhibition was observed in the case of thyme honey (21.17% inhibition), while goldenrod honey showed the highest capacity for BChE inhibition (33.89%). Our study showed that honeys may provide a rich source of cholinesterase inhibitors and, in this way, play a significant role in AD. MDPI 2022-07-20 /pmc/articles/PMC9319579/ /pubmed/35889933 http://dx.doi.org/10.3390/nu14142969 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Szwajgier, Dominik Baranowska-Wójcik, Ewa Winiarska-Mieczan, Anna Gajowniczek-Ałasa, Dorota Honeys as Possible Sources of Cholinesterase Inhibitors |
title | Honeys as Possible Sources of Cholinesterase Inhibitors |
title_full | Honeys as Possible Sources of Cholinesterase Inhibitors |
title_fullStr | Honeys as Possible Sources of Cholinesterase Inhibitors |
title_full_unstemmed | Honeys as Possible Sources of Cholinesterase Inhibitors |
title_short | Honeys as Possible Sources of Cholinesterase Inhibitors |
title_sort | honeys as possible sources of cholinesterase inhibitors |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319579/ https://www.ncbi.nlm.nih.gov/pubmed/35889933 http://dx.doi.org/10.3390/nu14142969 |
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