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Honeys as Possible Sources of Cholinesterase Inhibitors

Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterised by low levels of the neurotransmitter (acetylcholine), oxidative stress, and inflammation of the central nervous system. The only currently available form of treatment entails the administration of AChE/BChE (acetylcho...

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Autores principales: Szwajgier, Dominik, Baranowska-Wójcik, Ewa, Winiarska-Mieczan, Anna, Gajowniczek-Ałasa, Dorota
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319579/
https://www.ncbi.nlm.nih.gov/pubmed/35889933
http://dx.doi.org/10.3390/nu14142969
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author Szwajgier, Dominik
Baranowska-Wójcik, Ewa
Winiarska-Mieczan, Anna
Gajowniczek-Ałasa, Dorota
author_facet Szwajgier, Dominik
Baranowska-Wójcik, Ewa
Winiarska-Mieczan, Anna
Gajowniczek-Ałasa, Dorota
author_sort Szwajgier, Dominik
collection PubMed
description Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterised by low levels of the neurotransmitter (acetylcholine), oxidative stress, and inflammation of the central nervous system. The only currently available form of treatment entails the administration of AChE/BChE (acetylcholinesterase/butyrylcholinesterase) inhibitors to patients diagnosed with the disease. However, AD prevention is possible by administering the correct inhibitors with food. The aim of this study was to examine 19 types of honey in terms of their contents of cholinesterase inhibitors. The inhibition of AChE and BChE relative to the respective honey samples was evaluated using Ellman’s colorimetric method, including the “false-positive” effect. The highest potential for AChE inhibition was observed in the case of thyme honey (21.17% inhibition), while goldenrod honey showed the highest capacity for BChE inhibition (33.89%). Our study showed that honeys may provide a rich source of cholinesterase inhibitors and, in this way, play a significant role in AD.
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spelling pubmed-93195792022-07-27 Honeys as Possible Sources of Cholinesterase Inhibitors Szwajgier, Dominik Baranowska-Wójcik, Ewa Winiarska-Mieczan, Anna Gajowniczek-Ałasa, Dorota Nutrients Article Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterised by low levels of the neurotransmitter (acetylcholine), oxidative stress, and inflammation of the central nervous system. The only currently available form of treatment entails the administration of AChE/BChE (acetylcholinesterase/butyrylcholinesterase) inhibitors to patients diagnosed with the disease. However, AD prevention is possible by administering the correct inhibitors with food. The aim of this study was to examine 19 types of honey in terms of their contents of cholinesterase inhibitors. The inhibition of AChE and BChE relative to the respective honey samples was evaluated using Ellman’s colorimetric method, including the “false-positive” effect. The highest potential for AChE inhibition was observed in the case of thyme honey (21.17% inhibition), while goldenrod honey showed the highest capacity for BChE inhibition (33.89%). Our study showed that honeys may provide a rich source of cholinesterase inhibitors and, in this way, play a significant role in AD. MDPI 2022-07-20 /pmc/articles/PMC9319579/ /pubmed/35889933 http://dx.doi.org/10.3390/nu14142969 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Szwajgier, Dominik
Baranowska-Wójcik, Ewa
Winiarska-Mieczan, Anna
Gajowniczek-Ałasa, Dorota
Honeys as Possible Sources of Cholinesterase Inhibitors
title Honeys as Possible Sources of Cholinesterase Inhibitors
title_full Honeys as Possible Sources of Cholinesterase Inhibitors
title_fullStr Honeys as Possible Sources of Cholinesterase Inhibitors
title_full_unstemmed Honeys as Possible Sources of Cholinesterase Inhibitors
title_short Honeys as Possible Sources of Cholinesterase Inhibitors
title_sort honeys as possible sources of cholinesterase inhibitors
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319579/
https://www.ncbi.nlm.nih.gov/pubmed/35889933
http://dx.doi.org/10.3390/nu14142969
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