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Darier Disease with Psoriasis

Darier disease is an autosomal dominant disorder with dark crusty patches and is classified as hereditary acantholytic dermatosis. Keratotic papules and crust are often present on the scalp, forehead, chest, back, upper arms, elbows, groin, and behind the ears, predominantly in seborrheic areas. A 4...

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Autores principales: Kang, Seok-Young, Lee, So-Yeon, Park, Jin-Seo, Kim, Jin-Cheol, Chung, Bo-Young, Park, Chun-Wook, Kim, Hye-One
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319658/
https://www.ncbi.nlm.nih.gov/pubmed/35888621
http://dx.doi.org/10.3390/medicina58070902
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author Kang, Seok-Young
Lee, So-Yeon
Park, Jin-Seo
Kim, Jin-Cheol
Chung, Bo-Young
Park, Chun-Wook
Kim, Hye-One
author_facet Kang, Seok-Young
Lee, So-Yeon
Park, Jin-Seo
Kim, Jin-Cheol
Chung, Bo-Young
Park, Chun-Wook
Kim, Hye-One
author_sort Kang, Seok-Young
collection PubMed
description Darier disease is an autosomal dominant disorder with dark crusty patches and is classified as hereditary acantholytic dermatosis. Keratotic papules and crust are often present on the scalp, forehead, chest, back, upper arms, elbows, groin, and behind the ears, predominantly in seborrheic areas. A 48-year-old male patient presented skin lesions with pruritus on the trunk and both upper and lower extremities. He first noticed the lesion 15 years before. On physical examination, there were multiple erythematous papules with crust on the trunk and red-brown colored keratotic plaque on both extremities. The suspected histopathological diagnosis was psoriasis vulgaris. The patient’s skin lesions and pruritus were significantly improved after the psoriasis treatment. While continuing psoriasis treatment, the patient showed sudden worsening of the skin lesions on the scalp, abdomen, and fingernails (V-shaped nicks) with pruritus. Punch biopsy was performed on the abdominal lesion again and the final diagnosis was Darier disease. The patient was then treated using alitretinoin while maintaining the use of guselkumab for psoriasis. There are only a few cases that we found in which patients with Darier disease also had psoriasis. We report this rare case of Darier disease with psoriasis and propose that an additional biopsy might be necessary for accurate diagnosis and proper treatment.
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spelling pubmed-93196582022-07-27 Darier Disease with Psoriasis Kang, Seok-Young Lee, So-Yeon Park, Jin-Seo Kim, Jin-Cheol Chung, Bo-Young Park, Chun-Wook Kim, Hye-One Medicina (Kaunas) Case Report Darier disease is an autosomal dominant disorder with dark crusty patches and is classified as hereditary acantholytic dermatosis. Keratotic papules and crust are often present on the scalp, forehead, chest, back, upper arms, elbows, groin, and behind the ears, predominantly in seborrheic areas. A 48-year-old male patient presented skin lesions with pruritus on the trunk and both upper and lower extremities. He first noticed the lesion 15 years before. On physical examination, there were multiple erythematous papules with crust on the trunk and red-brown colored keratotic plaque on both extremities. The suspected histopathological diagnosis was psoriasis vulgaris. The patient’s skin lesions and pruritus were significantly improved after the psoriasis treatment. While continuing psoriasis treatment, the patient showed sudden worsening of the skin lesions on the scalp, abdomen, and fingernails (V-shaped nicks) with pruritus. Punch biopsy was performed on the abdominal lesion again and the final diagnosis was Darier disease. The patient was then treated using alitretinoin while maintaining the use of guselkumab for psoriasis. There are only a few cases that we found in which patients with Darier disease also had psoriasis. We report this rare case of Darier disease with psoriasis and propose that an additional biopsy might be necessary for accurate diagnosis and proper treatment. MDPI 2022-07-06 /pmc/articles/PMC9319658/ /pubmed/35888621 http://dx.doi.org/10.3390/medicina58070902 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Kang, Seok-Young
Lee, So-Yeon
Park, Jin-Seo
Kim, Jin-Cheol
Chung, Bo-Young
Park, Chun-Wook
Kim, Hye-One
Darier Disease with Psoriasis
title Darier Disease with Psoriasis
title_full Darier Disease with Psoriasis
title_fullStr Darier Disease with Psoriasis
title_full_unstemmed Darier Disease with Psoriasis
title_short Darier Disease with Psoriasis
title_sort darier disease with psoriasis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319658/
https://www.ncbi.nlm.nih.gov/pubmed/35888621
http://dx.doi.org/10.3390/medicina58070902
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