Cargando…
Rare Adverse Events Associated with BNT162b2 mRNA Vaccine (Pfizer-BioNTech): A Review of Large-Scale, Controlled Surveillance Studies
Given the increasing anti-vaccine movements erroneously touting vaccine danger, this review has investigated the rare adverse events potentially associated with BNT162b2 (Pfizer-BioNTech), an mRNA vaccine against the severe acute respiratory distress syndrome coronavirus 2 (SARS-CoV-2). Only real-wo...
Autores principales: | , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319660/ https://www.ncbi.nlm.nih.gov/pubmed/35891231 http://dx.doi.org/10.3390/vaccines10071067 |
_version_ | 1784755603929825280 |
---|---|
author | Yong, Shin-Jie Halim, Alice Halim, Michael Al Mutair, Abbas Alhumaid, Saad Al-Sihati, Jehad Albayat, Hawra Alsaeed, Mohammed Garout, Mohammed Al Azmi, Reyouf Aldakheel, Noor Alshukairi, Abeer N. Al Ali, Hani A. Almoumen, Adel A. Rabaan, Ali A. |
author_facet | Yong, Shin-Jie Halim, Alice Halim, Michael Al Mutair, Abbas Alhumaid, Saad Al-Sihati, Jehad Albayat, Hawra Alsaeed, Mohammed Garout, Mohammed Al Azmi, Reyouf Aldakheel, Noor Alshukairi, Abeer N. Al Ali, Hani A. Almoumen, Adel A. Rabaan, Ali A. |
author_sort | Yong, Shin-Jie |
collection | PubMed |
description | Given the increasing anti-vaccine movements erroneously touting vaccine danger, this review has investigated the rare adverse events potentially associated with BNT162b2 (Pfizer-BioNTech), an mRNA vaccine against the severe acute respiratory distress syndrome coronavirus 2 (SARS-CoV-2). Only real-world surveillance studies with at least 0.1 million BNT162b2-vaccinated participants and one unvaccinated control group were selected for review. A total of 21 studies examining the potential association of BNT162b2 with cardiovascular, herpetic, thrombotic or thrombocytopenic, neurological, mortality, and other miscellaneous rare adverse events were described in this review. Only myocarditis is consistently associated with BNT162b2. An unclear direction of association was seen with stroke (hemorrhagic and ischemic), herpes zoster, and paresthesia from BNT162b2, which may require more studies to resolve. Fortunately, most surveillance studies detected no increased risks of the remaining rare adverse events reviewed herein, further reassuring the safety of BNT162b2. In conclusion, this review has concisely summarized the current rare adverse events related and unrelated to BNT162b2, arguably for the first time in sufficient depth, to better communicate vaccine safety to the public. |
format | Online Article Text |
id | pubmed-9319660 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93196602022-07-27 Rare Adverse Events Associated with BNT162b2 mRNA Vaccine (Pfizer-BioNTech): A Review of Large-Scale, Controlled Surveillance Studies Yong, Shin-Jie Halim, Alice Halim, Michael Al Mutair, Abbas Alhumaid, Saad Al-Sihati, Jehad Albayat, Hawra Alsaeed, Mohammed Garout, Mohammed Al Azmi, Reyouf Aldakheel, Noor Alshukairi, Abeer N. Al Ali, Hani A. Almoumen, Adel A. Rabaan, Ali A. Vaccines (Basel) Review Given the increasing anti-vaccine movements erroneously touting vaccine danger, this review has investigated the rare adverse events potentially associated with BNT162b2 (Pfizer-BioNTech), an mRNA vaccine against the severe acute respiratory distress syndrome coronavirus 2 (SARS-CoV-2). Only real-world surveillance studies with at least 0.1 million BNT162b2-vaccinated participants and one unvaccinated control group were selected for review. A total of 21 studies examining the potential association of BNT162b2 with cardiovascular, herpetic, thrombotic or thrombocytopenic, neurological, mortality, and other miscellaneous rare adverse events were described in this review. Only myocarditis is consistently associated with BNT162b2. An unclear direction of association was seen with stroke (hemorrhagic and ischemic), herpes zoster, and paresthesia from BNT162b2, which may require more studies to resolve. Fortunately, most surveillance studies detected no increased risks of the remaining rare adverse events reviewed herein, further reassuring the safety of BNT162b2. In conclusion, this review has concisely summarized the current rare adverse events related and unrelated to BNT162b2, arguably for the first time in sufficient depth, to better communicate vaccine safety to the public. MDPI 2022-07-02 /pmc/articles/PMC9319660/ /pubmed/35891231 http://dx.doi.org/10.3390/vaccines10071067 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Yong, Shin-Jie Halim, Alice Halim, Michael Al Mutair, Abbas Alhumaid, Saad Al-Sihati, Jehad Albayat, Hawra Alsaeed, Mohammed Garout, Mohammed Al Azmi, Reyouf Aldakheel, Noor Alshukairi, Abeer N. Al Ali, Hani A. Almoumen, Adel A. Rabaan, Ali A. Rare Adverse Events Associated with BNT162b2 mRNA Vaccine (Pfizer-BioNTech): A Review of Large-Scale, Controlled Surveillance Studies |
title | Rare Adverse Events Associated with BNT162b2 mRNA Vaccine (Pfizer-BioNTech): A Review of Large-Scale, Controlled Surveillance Studies |
title_full | Rare Adverse Events Associated with BNT162b2 mRNA Vaccine (Pfizer-BioNTech): A Review of Large-Scale, Controlled Surveillance Studies |
title_fullStr | Rare Adverse Events Associated with BNT162b2 mRNA Vaccine (Pfizer-BioNTech): A Review of Large-Scale, Controlled Surveillance Studies |
title_full_unstemmed | Rare Adverse Events Associated with BNT162b2 mRNA Vaccine (Pfizer-BioNTech): A Review of Large-Scale, Controlled Surveillance Studies |
title_short | Rare Adverse Events Associated with BNT162b2 mRNA Vaccine (Pfizer-BioNTech): A Review of Large-Scale, Controlled Surveillance Studies |
title_sort | rare adverse events associated with bnt162b2 mrna vaccine (pfizer-biontech): a review of large-scale, controlled surveillance studies |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319660/ https://www.ncbi.nlm.nih.gov/pubmed/35891231 http://dx.doi.org/10.3390/vaccines10071067 |
work_keys_str_mv | AT yongshinjie rareadverseeventsassociatedwithbnt162b2mrnavaccinepfizerbiontechareviewoflargescalecontrolledsurveillancestudies AT halimalice rareadverseeventsassociatedwithbnt162b2mrnavaccinepfizerbiontechareviewoflargescalecontrolledsurveillancestudies AT halimmichael rareadverseeventsassociatedwithbnt162b2mrnavaccinepfizerbiontechareviewoflargescalecontrolledsurveillancestudies AT almutairabbas rareadverseeventsassociatedwithbnt162b2mrnavaccinepfizerbiontechareviewoflargescalecontrolledsurveillancestudies AT alhumaidsaad rareadverseeventsassociatedwithbnt162b2mrnavaccinepfizerbiontechareviewoflargescalecontrolledsurveillancestudies AT alsihatijehad rareadverseeventsassociatedwithbnt162b2mrnavaccinepfizerbiontechareviewoflargescalecontrolledsurveillancestudies AT albayathawra rareadverseeventsassociatedwithbnt162b2mrnavaccinepfizerbiontechareviewoflargescalecontrolledsurveillancestudies AT alsaeedmohammed rareadverseeventsassociatedwithbnt162b2mrnavaccinepfizerbiontechareviewoflargescalecontrolledsurveillancestudies AT garoutmohammed rareadverseeventsassociatedwithbnt162b2mrnavaccinepfizerbiontechareviewoflargescalecontrolledsurveillancestudies AT alazmireyouf rareadverseeventsassociatedwithbnt162b2mrnavaccinepfizerbiontechareviewoflargescalecontrolledsurveillancestudies AT aldakheelnoor rareadverseeventsassociatedwithbnt162b2mrnavaccinepfizerbiontechareviewoflargescalecontrolledsurveillancestudies AT alshukairiabeern rareadverseeventsassociatedwithbnt162b2mrnavaccinepfizerbiontechareviewoflargescalecontrolledsurveillancestudies AT alalihania rareadverseeventsassociatedwithbnt162b2mrnavaccinepfizerbiontechareviewoflargescalecontrolledsurveillancestudies AT almoumenadela rareadverseeventsassociatedwithbnt162b2mrnavaccinepfizerbiontechareviewoflargescalecontrolledsurveillancestudies AT rabaanalia rareadverseeventsassociatedwithbnt162b2mrnavaccinepfizerbiontechareviewoflargescalecontrolledsurveillancestudies |