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The Influence of Oncogenic Viruses in Renal Carcinogenesis: Pros and Cons

Viral infections are major contributors to the global cancer burden. Recent advances have revealed that known oncogenic viruses promote carcinogenesis through shared host cell targets and pathways. The aim of this review is to point out the connection between several oncogenic viruses from the Polyo...

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Autores principales: Manole, Bianca, Damian, Costin, Giusca, Simona-Eliza, Caruntu, Irina Draga, Porumb-Andrese, Elena, Lunca, Catalina, Dorneanu, Olivia Simona, Iancu, Luminita Smaranda, Ursu, Ramona Gabriela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319782/
https://www.ncbi.nlm.nih.gov/pubmed/35890003
http://dx.doi.org/10.3390/pathogens11070757
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author Manole, Bianca
Damian, Costin
Giusca, Simona-Eliza
Caruntu, Irina Draga
Porumb-Andrese, Elena
Lunca, Catalina
Dorneanu, Olivia Simona
Iancu, Luminita Smaranda
Ursu, Ramona Gabriela
author_facet Manole, Bianca
Damian, Costin
Giusca, Simona-Eliza
Caruntu, Irina Draga
Porumb-Andrese, Elena
Lunca, Catalina
Dorneanu, Olivia Simona
Iancu, Luminita Smaranda
Ursu, Ramona Gabriela
author_sort Manole, Bianca
collection PubMed
description Viral infections are major contributors to the global cancer burden. Recent advances have revealed that known oncogenic viruses promote carcinogenesis through shared host cell targets and pathways. The aim of this review is to point out the connection between several oncogenic viruses from the Polyomaviridae, Herpesviridae and Flaviviridae families and renal carcinogenesis, highlighting their involvement in the carcinogenic mechanism. We performed a systematic search of the PubMed and EMBASE databases, which was carried out for all the published studies on RCC in the last 10 years, using the following search algorithm: renal cell carcinoma (RCC) and urothelial carcinoma, and oncogenic viruses (BKPyV, EBV, HCV, HPV and Kaposi Sarcoma Virus), RCC and biomarkers, immunohistochemistry (IHC). Our analysis included studies that were published in English from the 1st of January 2012 to the 1st of May 2022 and that described and analyzed the assays used for the detection of oncogenic viruses in RCC and urothelial carcinoma. The virus most frequently associated with RCC was BKPyV. This review of the literature will help to understand the pathogenic mechanism of the main type of renal malignancy and whether the viral etiology can be confirmed, at a minimum, as a co-factor. In consequence, these data can contribute to the development of new therapeutic strategies. A virus-induced tumor could be efficiently prevented by vaccination or treatment with oncolytic viral therapy and/or by targeted therapy.
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spelling pubmed-93197822022-07-27 The Influence of Oncogenic Viruses in Renal Carcinogenesis: Pros and Cons Manole, Bianca Damian, Costin Giusca, Simona-Eliza Caruntu, Irina Draga Porumb-Andrese, Elena Lunca, Catalina Dorneanu, Olivia Simona Iancu, Luminita Smaranda Ursu, Ramona Gabriela Pathogens Review Viral infections are major contributors to the global cancer burden. Recent advances have revealed that known oncogenic viruses promote carcinogenesis through shared host cell targets and pathways. The aim of this review is to point out the connection between several oncogenic viruses from the Polyomaviridae, Herpesviridae and Flaviviridae families and renal carcinogenesis, highlighting their involvement in the carcinogenic mechanism. We performed a systematic search of the PubMed and EMBASE databases, which was carried out for all the published studies on RCC in the last 10 years, using the following search algorithm: renal cell carcinoma (RCC) and urothelial carcinoma, and oncogenic viruses (BKPyV, EBV, HCV, HPV and Kaposi Sarcoma Virus), RCC and biomarkers, immunohistochemistry (IHC). Our analysis included studies that were published in English from the 1st of January 2012 to the 1st of May 2022 and that described and analyzed the assays used for the detection of oncogenic viruses in RCC and urothelial carcinoma. The virus most frequently associated with RCC was BKPyV. This review of the literature will help to understand the pathogenic mechanism of the main type of renal malignancy and whether the viral etiology can be confirmed, at a minimum, as a co-factor. In consequence, these data can contribute to the development of new therapeutic strategies. A virus-induced tumor could be efficiently prevented by vaccination or treatment with oncolytic viral therapy and/or by targeted therapy. MDPI 2022-07-02 /pmc/articles/PMC9319782/ /pubmed/35890003 http://dx.doi.org/10.3390/pathogens11070757 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Manole, Bianca
Damian, Costin
Giusca, Simona-Eliza
Caruntu, Irina Draga
Porumb-Andrese, Elena
Lunca, Catalina
Dorneanu, Olivia Simona
Iancu, Luminita Smaranda
Ursu, Ramona Gabriela
The Influence of Oncogenic Viruses in Renal Carcinogenesis: Pros and Cons
title The Influence of Oncogenic Viruses in Renal Carcinogenesis: Pros and Cons
title_full The Influence of Oncogenic Viruses in Renal Carcinogenesis: Pros and Cons
title_fullStr The Influence of Oncogenic Viruses in Renal Carcinogenesis: Pros and Cons
title_full_unstemmed The Influence of Oncogenic Viruses in Renal Carcinogenesis: Pros and Cons
title_short The Influence of Oncogenic Viruses in Renal Carcinogenesis: Pros and Cons
title_sort influence of oncogenic viruses in renal carcinogenesis: pros and cons
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319782/
https://www.ncbi.nlm.nih.gov/pubmed/35890003
http://dx.doi.org/10.3390/pathogens11070757
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