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Diverse Mechanisms of Resistance against Osimertinib, a Third-Generation EGFR-TKI, in Lung Adenocarcinoma Cells with an EGFR-Activating Mutation

Osimertinib, a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI), is used as a first-line treatment for patients with EGFR-mutant non-small cell lung cancer (NSCLC). However, the mechanisms underlying its anticancer activity, particularly the subsequent develop...

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Detalles Bibliográficos
Autores principales:	Nishihara, Shigetoshi, Yamaoka, Toshimitsu, Ishikawa, Fumihiro, Ohmori, Tohru, Ando, Koichi, Kusumoto, Sojiro, Kishino, Yasunari, Manabe, Ryo, Hasebe, Yuki, Sagara, Hironori, Yoshida, Hitoshi, Tsurutani, Junji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319811/ https://www.ncbi.nlm.nih.gov/pubmed/35883645 http://dx.doi.org/10.3390/cells11142201

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