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The Influence of Orthopedic Surgery on Circulating Metabolite Levels, and their Associations with the Incidence of Postoperative Delirium

The mechanisms underlying the occurrence of postoperative delirium development are unclear and measurement of plasma metabolites may improve understanding of its causes. Participants (n = 54) matched for age and gender were sampled from an observational cohort study investigating postoperative delir...

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Autores principales: Jung, Mijin, Pan, Xiaobei, Cunningham, Emma L., Passmore, Anthony P., McGuinness, Bernadette, McAuley, Daniel F., Beverland, David, O’Brien, Seamus, Mawhinney, Tim, Schott, Jonathan M., Zetterberg, Henrik, Green, Brian D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319890/
https://www.ncbi.nlm.nih.gov/pubmed/35888740
http://dx.doi.org/10.3390/metabo12070616
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author Jung, Mijin
Pan, Xiaobei
Cunningham, Emma L.
Passmore, Anthony P.
McGuinness, Bernadette
McAuley, Daniel F.
Beverland, David
O’Brien, Seamus
Mawhinney, Tim
Schott, Jonathan M.
Zetterberg, Henrik
Green, Brian D.
author_facet Jung, Mijin
Pan, Xiaobei
Cunningham, Emma L.
Passmore, Anthony P.
McGuinness, Bernadette
McAuley, Daniel F.
Beverland, David
O’Brien, Seamus
Mawhinney, Tim
Schott, Jonathan M.
Zetterberg, Henrik
Green, Brian D.
author_sort Jung, Mijin
collection PubMed
description The mechanisms underlying the occurrence of postoperative delirium development are unclear and measurement of plasma metabolites may improve understanding of its causes. Participants (n = 54) matched for age and gender were sampled from an observational cohort study investigating postoperative delirium. Participants were ≥65 years without a diagnosis of dementia and presented for primary elective hip or knee arthroplasty. Plasma samples collected pre- and postoperatively were grouped as either control (n = 26, aged: 75.8 ± 5.2) or delirium (n = 28, aged: 76.2 ± 5.7). Widespread changes in plasma metabolite levels occurred following surgery. The only metabolites significantly differing between corresponding control and delirium samples were ornithine and spermine. In delirium cases, ornithine was 17.6% higher preoperatively, and spermine was 12.0% higher postoperatively. Changes were not associated with various perioperative factors. In binary logistic regression modeling, these two metabolites did not confer a significantly increased risk of delirium. These findings support the hypothesis that disturbed polyamine metabolism is an underlying factor in delirium that warrants further investigation.
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spelling pubmed-93198902022-07-27 The Influence of Orthopedic Surgery on Circulating Metabolite Levels, and their Associations with the Incidence of Postoperative Delirium Jung, Mijin Pan, Xiaobei Cunningham, Emma L. Passmore, Anthony P. McGuinness, Bernadette McAuley, Daniel F. Beverland, David O’Brien, Seamus Mawhinney, Tim Schott, Jonathan M. Zetterberg, Henrik Green, Brian D. Metabolites Article The mechanisms underlying the occurrence of postoperative delirium development are unclear and measurement of plasma metabolites may improve understanding of its causes. Participants (n = 54) matched for age and gender were sampled from an observational cohort study investigating postoperative delirium. Participants were ≥65 years without a diagnosis of dementia and presented for primary elective hip or knee arthroplasty. Plasma samples collected pre- and postoperatively were grouped as either control (n = 26, aged: 75.8 ± 5.2) or delirium (n = 28, aged: 76.2 ± 5.7). Widespread changes in plasma metabolite levels occurred following surgery. The only metabolites significantly differing between corresponding control and delirium samples were ornithine and spermine. In delirium cases, ornithine was 17.6% higher preoperatively, and spermine was 12.0% higher postoperatively. Changes were not associated with various perioperative factors. In binary logistic regression modeling, these two metabolites did not confer a significantly increased risk of delirium. These findings support the hypothesis that disturbed polyamine metabolism is an underlying factor in delirium that warrants further investigation. MDPI 2022-07-01 /pmc/articles/PMC9319890/ /pubmed/35888740 http://dx.doi.org/10.3390/metabo12070616 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jung, Mijin
Pan, Xiaobei
Cunningham, Emma L.
Passmore, Anthony P.
McGuinness, Bernadette
McAuley, Daniel F.
Beverland, David
O’Brien, Seamus
Mawhinney, Tim
Schott, Jonathan M.
Zetterberg, Henrik
Green, Brian D.
The Influence of Orthopedic Surgery on Circulating Metabolite Levels, and their Associations with the Incidence of Postoperative Delirium
title The Influence of Orthopedic Surgery on Circulating Metabolite Levels, and their Associations with the Incidence of Postoperative Delirium
title_full The Influence of Orthopedic Surgery on Circulating Metabolite Levels, and their Associations with the Incidence of Postoperative Delirium
title_fullStr The Influence of Orthopedic Surgery on Circulating Metabolite Levels, and their Associations with the Incidence of Postoperative Delirium
title_full_unstemmed The Influence of Orthopedic Surgery on Circulating Metabolite Levels, and their Associations with the Incidence of Postoperative Delirium
title_short The Influence of Orthopedic Surgery on Circulating Metabolite Levels, and their Associations with the Incidence of Postoperative Delirium
title_sort influence of orthopedic surgery on circulating metabolite levels, and their associations with the incidence of postoperative delirium
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319890/
https://www.ncbi.nlm.nih.gov/pubmed/35888740
http://dx.doi.org/10.3390/metabo12070616
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