Histone Deacetylase 3 Inhibitor Alleviates Cerebellar Defects in Perinatal Hypothyroid Mice by Stimulating Histone Acetylation and Transcription at Thyroid Hormone-Responsive Gene Loci

Perinatal hypothyroidism impairs cerebellar organogenesis and results in motor coordination defects. The thyroid hormone receptor binds to corepressor complexes containing histone deacetylase (HDAC) 3 in the absence of ligands and acts as a transcriptional repressor. Although histone acetylation sta...

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Detalles Bibliográficos
Autores principales: Susetyo, Alvin, Ishii, Sumiyasu, Fujiwara, Yuki, Amano, Izuki, Koibuchi, Noriyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319938/
https://www.ncbi.nlm.nih.gov/pubmed/35887216
http://dx.doi.org/10.3390/ijms23147869

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9319938/
https://www.ncbi.nlm.nih.gov/pubmed/35887216
http://dx.doi.org/10.3390/ijms23147869

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