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Variant Allele of ALDH2, rs671, Associates with Attenuated Post-Vaccination Response in Anti-SARS-CoV-2 Spike Protein IgG: A Prospective Study in the Japanese General Population

Uncovering the predictors of vaccine immunogenicity is essential for infection control. We have reported that the most prevalent polymorphism of the aldehyde dehydrogenase 2 gene (ALDH2), rs671, may be associated with an attenuated immune system. To test the inverse relationship between rs671 and an...

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Autores principales: Matsumoto, Akiko, Hara, Megumi, Ashenagar, Mohammad Said, Tokiya, Mikiko, Sawada, Takeshi, Iwasaka, Chiharu, Furukawa, Takuma, Kitagawa, Kyoko, Miyake, Yasunobu, Hirota, Yoshio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320019/
https://www.ncbi.nlm.nih.gov/pubmed/35891198
http://dx.doi.org/10.3390/vaccines10071035
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author Matsumoto, Akiko
Hara, Megumi
Ashenagar, Mohammad Said
Tokiya, Mikiko
Sawada, Takeshi
Iwasaka, Chiharu
Furukawa, Takuma
Kitagawa, Kyoko
Miyake, Yasunobu
Hirota, Yoshio
author_facet Matsumoto, Akiko
Hara, Megumi
Ashenagar, Mohammad Said
Tokiya, Mikiko
Sawada, Takeshi
Iwasaka, Chiharu
Furukawa, Takuma
Kitagawa, Kyoko
Miyake, Yasunobu
Hirota, Yoshio
author_sort Matsumoto, Akiko
collection PubMed
description Uncovering the predictors of vaccine immunogenicity is essential for infection control. We have reported that the most prevalent polymorphism of the aldehyde dehydrogenase 2 gene (ALDH2), rs671, may be associated with an attenuated immune system. To test the inverse relationship between rs671 and antibody production after COVID-19 vaccination, the levels of anti-SARS-CoV-2 Spike protein S1 subunit (S1) IgG were repeatedly measured for four months before and after vaccination with BNT162b2 or mRNA-1273, in 88 Japanese workers and students (including 45 females, aged 21–56 years, with an rs671 variant allele frequency of 0.3). The mixed model including fixed effects of the vaccine type, weeks post vaccination (categorical variable), sex, age, height, smoking status, ethanol intake, exercise habit, perceived stress, steroid use, allergic diseases, and dyslipidemia, indicated an inverse association between log-transformed anti-S1 IgG levels and the number of rs671 variant alleles (partial regression coefficient = −0.15, p = 0.002). Our study indicated for the first time that the variant allele of ALDH2, rs671, is associated with the attenuated immunogenicity of COVID-19 mRNA vaccines. Our finding may provide a basis for personalized disease prevention based on a genetic polymorphism that is prevalent among East Asians.
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spelling pubmed-93200192022-07-27 Variant Allele of ALDH2, rs671, Associates with Attenuated Post-Vaccination Response in Anti-SARS-CoV-2 Spike Protein IgG: A Prospective Study in the Japanese General Population Matsumoto, Akiko Hara, Megumi Ashenagar, Mohammad Said Tokiya, Mikiko Sawada, Takeshi Iwasaka, Chiharu Furukawa, Takuma Kitagawa, Kyoko Miyake, Yasunobu Hirota, Yoshio Vaccines (Basel) Communication Uncovering the predictors of vaccine immunogenicity is essential for infection control. We have reported that the most prevalent polymorphism of the aldehyde dehydrogenase 2 gene (ALDH2), rs671, may be associated with an attenuated immune system. To test the inverse relationship between rs671 and antibody production after COVID-19 vaccination, the levels of anti-SARS-CoV-2 Spike protein S1 subunit (S1) IgG were repeatedly measured for four months before and after vaccination with BNT162b2 or mRNA-1273, in 88 Japanese workers and students (including 45 females, aged 21–56 years, with an rs671 variant allele frequency of 0.3). The mixed model including fixed effects of the vaccine type, weeks post vaccination (categorical variable), sex, age, height, smoking status, ethanol intake, exercise habit, perceived stress, steroid use, allergic diseases, and dyslipidemia, indicated an inverse association between log-transformed anti-S1 IgG levels and the number of rs671 variant alleles (partial regression coefficient = −0.15, p = 0.002). Our study indicated for the first time that the variant allele of ALDH2, rs671, is associated with the attenuated immunogenicity of COVID-19 mRNA vaccines. Our finding may provide a basis for personalized disease prevention based on a genetic polymorphism that is prevalent among East Asians. MDPI 2022-06-28 /pmc/articles/PMC9320019/ /pubmed/35891198 http://dx.doi.org/10.3390/vaccines10071035 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Matsumoto, Akiko
Hara, Megumi
Ashenagar, Mohammad Said
Tokiya, Mikiko
Sawada, Takeshi
Iwasaka, Chiharu
Furukawa, Takuma
Kitagawa, Kyoko
Miyake, Yasunobu
Hirota, Yoshio
Variant Allele of ALDH2, rs671, Associates with Attenuated Post-Vaccination Response in Anti-SARS-CoV-2 Spike Protein IgG: A Prospective Study in the Japanese General Population
title Variant Allele of ALDH2, rs671, Associates with Attenuated Post-Vaccination Response in Anti-SARS-CoV-2 Spike Protein IgG: A Prospective Study in the Japanese General Population
title_full Variant Allele of ALDH2, rs671, Associates with Attenuated Post-Vaccination Response in Anti-SARS-CoV-2 Spike Protein IgG: A Prospective Study in the Japanese General Population
title_fullStr Variant Allele of ALDH2, rs671, Associates with Attenuated Post-Vaccination Response in Anti-SARS-CoV-2 Spike Protein IgG: A Prospective Study in the Japanese General Population
title_full_unstemmed Variant Allele of ALDH2, rs671, Associates with Attenuated Post-Vaccination Response in Anti-SARS-CoV-2 Spike Protein IgG: A Prospective Study in the Japanese General Population
title_short Variant Allele of ALDH2, rs671, Associates with Attenuated Post-Vaccination Response in Anti-SARS-CoV-2 Spike Protein IgG: A Prospective Study in the Japanese General Population
title_sort variant allele of aldh2, rs671, associates with attenuated post-vaccination response in anti-sars-cov-2 spike protein igg: a prospective study in the japanese general population
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320019/
https://www.ncbi.nlm.nih.gov/pubmed/35891198
http://dx.doi.org/10.3390/vaccines10071035
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