Cargando…

Associated-Onset Symptoms and Post-COVID-19 Symptoms in Hospitalized COVID-19 Survivors Infected with Wuhan, Alpha or Delta SARS-CoV-2 Variant

This study compared associated-symptoms at the acute phase of infection and post-COVID-19 symptoms between individuals hospitalized with the Wuhan, Alpha or Delta SARS-CoV-2 variant. Non-vaccinated individuals hospitalized because of SARS-CoV-2 infection in one hospital during three different waves...

Descripción completa

Detalles Bibliográficos
Autores principales: Fernández-de-las-Peñas, César, Cancela-Cilleruelo, Ignacio, Rodríguez-Jiménez, Jorge, Gómez-Mayordomo, Victor, Pellicer-Valero, Oscar J., Martín-Guerrero, José D., Hernández-Barrera, Valentín, Arendt-Nielsen, Lars, Torres-Macho, Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320021/
https://www.ncbi.nlm.nih.gov/pubmed/35889971
http://dx.doi.org/10.3390/pathogens11070725
_version_ 1784755691691442176
author Fernández-de-las-Peñas, César
Cancela-Cilleruelo, Ignacio
Rodríguez-Jiménez, Jorge
Gómez-Mayordomo, Victor
Pellicer-Valero, Oscar J.
Martín-Guerrero, José D.
Hernández-Barrera, Valentín
Arendt-Nielsen, Lars
Torres-Macho, Juan
author_facet Fernández-de-las-Peñas, César
Cancela-Cilleruelo, Ignacio
Rodríguez-Jiménez, Jorge
Gómez-Mayordomo, Victor
Pellicer-Valero, Oscar J.
Martín-Guerrero, José D.
Hernández-Barrera, Valentín
Arendt-Nielsen, Lars
Torres-Macho, Juan
author_sort Fernández-de-las-Peñas, César
collection PubMed
description This study compared associated-symptoms at the acute phase of infection and post-COVID-19 symptoms between individuals hospitalized with the Wuhan, Alpha or Delta SARS-CoV-2 variant. Non-vaccinated individuals hospitalized because of SARS-CoV-2 infection in one hospital during three different waves of the pandemic (Wuhan, Alpha or Delta) were scheduled for a telephone interview. The presence of post-COVID-19 symptoms was systematically assessed. Hospitalization and clinical data were collected from medical records. A total of 201 patients infected with the Wuhan variant, 211 with the Alpha variant and 202 with Delta variant were assessed six months after hospitalization. Patients infected with the Wuhan variant had a greater number of symptoms at hospital admission (higher prevalence of fever, dyspnea or gastrointestinal problems) than those infected with Alpha or Delta variant (p < 0.01). A greater proportion of patients infected with the Delta variant reported headache, anosmia or ageusia as onset symptoms (p < 0.01). The mean number of post-COVID-19 symptoms was higher (p < 0.001) in individuals infected with the Wuhan variant (mean: 2.7 ± 1.3) than in those infected with the Alpha (mean: 1.8 ± 1.1) or Delta (mean: 2.1 ± 1.5) variant. Post-COVID-19 dyspnea was more prevalent (p < 0.001) in people infected with the Wuhan variant, whereas hair loss was higher in those infected with the Delta variant (p = 0.002). No differences in post-COVID-19 fatigue by SARS-CoV-2 variant were found (p = 0.594). Differences in COVID-19 associated onset symptoms and post-COVID-19 dyspnea were observed depending on the SARS-CoV-2 variant. The presence of fatigue was a common post-COVID-19 symptom to all SARS-CoV-2 variants.
format Online
Article
Text
id pubmed-9320021
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-93200212022-07-27 Associated-Onset Symptoms and Post-COVID-19 Symptoms in Hospitalized COVID-19 Survivors Infected with Wuhan, Alpha or Delta SARS-CoV-2 Variant Fernández-de-las-Peñas, César Cancela-Cilleruelo, Ignacio Rodríguez-Jiménez, Jorge Gómez-Mayordomo, Victor Pellicer-Valero, Oscar J. Martín-Guerrero, José D. Hernández-Barrera, Valentín Arendt-Nielsen, Lars Torres-Macho, Juan Pathogens Article This study compared associated-symptoms at the acute phase of infection and post-COVID-19 symptoms between individuals hospitalized with the Wuhan, Alpha or Delta SARS-CoV-2 variant. Non-vaccinated individuals hospitalized because of SARS-CoV-2 infection in one hospital during three different waves of the pandemic (Wuhan, Alpha or Delta) were scheduled for a telephone interview. The presence of post-COVID-19 symptoms was systematically assessed. Hospitalization and clinical data were collected from medical records. A total of 201 patients infected with the Wuhan variant, 211 with the Alpha variant and 202 with Delta variant were assessed six months after hospitalization. Patients infected with the Wuhan variant had a greater number of symptoms at hospital admission (higher prevalence of fever, dyspnea or gastrointestinal problems) than those infected with Alpha or Delta variant (p < 0.01). A greater proportion of patients infected with the Delta variant reported headache, anosmia or ageusia as onset symptoms (p < 0.01). The mean number of post-COVID-19 symptoms was higher (p < 0.001) in individuals infected with the Wuhan variant (mean: 2.7 ± 1.3) than in those infected with the Alpha (mean: 1.8 ± 1.1) or Delta (mean: 2.1 ± 1.5) variant. Post-COVID-19 dyspnea was more prevalent (p < 0.001) in people infected with the Wuhan variant, whereas hair loss was higher in those infected with the Delta variant (p = 0.002). No differences in post-COVID-19 fatigue by SARS-CoV-2 variant were found (p = 0.594). Differences in COVID-19 associated onset symptoms and post-COVID-19 dyspnea were observed depending on the SARS-CoV-2 variant. The presence of fatigue was a common post-COVID-19 symptom to all SARS-CoV-2 variants. MDPI 2022-06-25 /pmc/articles/PMC9320021/ /pubmed/35889971 http://dx.doi.org/10.3390/pathogens11070725 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Fernández-de-las-Peñas, César
Cancela-Cilleruelo, Ignacio
Rodríguez-Jiménez, Jorge
Gómez-Mayordomo, Victor
Pellicer-Valero, Oscar J.
Martín-Guerrero, José D.
Hernández-Barrera, Valentín
Arendt-Nielsen, Lars
Torres-Macho, Juan
Associated-Onset Symptoms and Post-COVID-19 Symptoms in Hospitalized COVID-19 Survivors Infected with Wuhan, Alpha or Delta SARS-CoV-2 Variant
title Associated-Onset Symptoms and Post-COVID-19 Symptoms in Hospitalized COVID-19 Survivors Infected with Wuhan, Alpha or Delta SARS-CoV-2 Variant
title_full Associated-Onset Symptoms and Post-COVID-19 Symptoms in Hospitalized COVID-19 Survivors Infected with Wuhan, Alpha or Delta SARS-CoV-2 Variant
title_fullStr Associated-Onset Symptoms and Post-COVID-19 Symptoms in Hospitalized COVID-19 Survivors Infected with Wuhan, Alpha or Delta SARS-CoV-2 Variant
title_full_unstemmed Associated-Onset Symptoms and Post-COVID-19 Symptoms in Hospitalized COVID-19 Survivors Infected with Wuhan, Alpha or Delta SARS-CoV-2 Variant
title_short Associated-Onset Symptoms and Post-COVID-19 Symptoms in Hospitalized COVID-19 Survivors Infected with Wuhan, Alpha or Delta SARS-CoV-2 Variant
title_sort associated-onset symptoms and post-covid-19 symptoms in hospitalized covid-19 survivors infected with wuhan, alpha or delta sars-cov-2 variant
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320021/
https://www.ncbi.nlm.nih.gov/pubmed/35889971
http://dx.doi.org/10.3390/pathogens11070725
work_keys_str_mv AT fernandezdelaspenascesar associatedonsetsymptomsandpostcovid19symptomsinhospitalizedcovid19survivorsinfectedwithwuhanalphaordeltasarscov2variant
AT cancelacillerueloignacio associatedonsetsymptomsandpostcovid19symptomsinhospitalizedcovid19survivorsinfectedwithwuhanalphaordeltasarscov2variant
AT rodriguezjimenezjorge associatedonsetsymptomsandpostcovid19symptomsinhospitalizedcovid19survivorsinfectedwithwuhanalphaordeltasarscov2variant
AT gomezmayordomovictor associatedonsetsymptomsandpostcovid19symptomsinhospitalizedcovid19survivorsinfectedwithwuhanalphaordeltasarscov2variant
AT pellicervalerooscarj associatedonsetsymptomsandpostcovid19symptomsinhospitalizedcovid19survivorsinfectedwithwuhanalphaordeltasarscov2variant
AT martinguerrerojosed associatedonsetsymptomsandpostcovid19symptomsinhospitalizedcovid19survivorsinfectedwithwuhanalphaordeltasarscov2variant
AT hernandezbarreravalentin associatedonsetsymptomsandpostcovid19symptomsinhospitalizedcovid19survivorsinfectedwithwuhanalphaordeltasarscov2variant
AT arendtnielsenlars associatedonsetsymptomsandpostcovid19symptomsinhospitalizedcovid19survivorsinfectedwithwuhanalphaordeltasarscov2variant
AT torresmachojuan associatedonsetsymptomsandpostcovid19symptomsinhospitalizedcovid19survivorsinfectedwithwuhanalphaordeltasarscov2variant