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Euphorbia characias Extract: Inhibition of Skin Aging-Related Enzymes and Nanoformulation

Plant extracts have long served as important sources of bioactive compounds, and they are currently the focus of extensive research in the development of novel preventive and therapeutic strategies. However, their health benefits are often limited by low bioavailability. Nanoparticle delivery system...

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Autores principales: Pintus, Francesca, Floris, Sonia, Fais, Antonella, Era, Benedetta, Porcedda, Clara, Tuberoso, Carlo Ignazio Giovanni, Caddeo, Carla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320162/
https://www.ncbi.nlm.nih.gov/pubmed/35890482
http://dx.doi.org/10.3390/plants11141849
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author Pintus, Francesca
Floris, Sonia
Fais, Antonella
Era, Benedetta
Porcedda, Clara
Tuberoso, Carlo Ignazio Giovanni
Caddeo, Carla
author_facet Pintus, Francesca
Floris, Sonia
Fais, Antonella
Era, Benedetta
Porcedda, Clara
Tuberoso, Carlo Ignazio Giovanni
Caddeo, Carla
author_sort Pintus, Francesca
collection PubMed
description Plant extracts have long served as important sources of bioactive compounds, and they are currently the focus of extensive research in the development of novel preventive and therapeutic strategies. However, their health benefits are often limited by low bioavailability. Nanoparticle delivery systems can represent a solution to such limitations. Euphorbia characias is a Mediterranean shrub known to have biological activities, such as inhibiting tyrosinase and showing a potential role as a skin-whitening agent. In this study, an ethanolic extract from E. characias leaves was tested for its inhibitory activity on skin-related enzymes, such as elastase, collagenase, and hyaluronidase, and for sun protection factors. Moreover, the extract was formulated in phospholipid vesicles to improve its local bioavailability and applicability. The vesicles were characterized by size, surface charge, storage stability, and entrapment efficiency. The nanoformulation was also evaluated for antioxidant activity and assayed for cytocompatibility and anti-tyrosinase activity in melanoma cells. Our findings demonstrated that the extract has a photo-protective effect and enzyme-inhibitory properties. E. characias nanoformulation was also cytocompatible and improved the extract’s activity in the cells, suggesting a potential skin application for antimelanogenic treatments and confirming the key role of nanotechnological approaches to maximize plant extract’s potentialities.
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spelling pubmed-93201622022-07-27 Euphorbia characias Extract: Inhibition of Skin Aging-Related Enzymes and Nanoformulation Pintus, Francesca Floris, Sonia Fais, Antonella Era, Benedetta Porcedda, Clara Tuberoso, Carlo Ignazio Giovanni Caddeo, Carla Plants (Basel) Article Plant extracts have long served as important sources of bioactive compounds, and they are currently the focus of extensive research in the development of novel preventive and therapeutic strategies. However, their health benefits are often limited by low bioavailability. Nanoparticle delivery systems can represent a solution to such limitations. Euphorbia characias is a Mediterranean shrub known to have biological activities, such as inhibiting tyrosinase and showing a potential role as a skin-whitening agent. In this study, an ethanolic extract from E. characias leaves was tested for its inhibitory activity on skin-related enzymes, such as elastase, collagenase, and hyaluronidase, and for sun protection factors. Moreover, the extract was formulated in phospholipid vesicles to improve its local bioavailability and applicability. The vesicles were characterized by size, surface charge, storage stability, and entrapment efficiency. The nanoformulation was also evaluated for antioxidant activity and assayed for cytocompatibility and anti-tyrosinase activity in melanoma cells. Our findings demonstrated that the extract has a photo-protective effect and enzyme-inhibitory properties. E. characias nanoformulation was also cytocompatible and improved the extract’s activity in the cells, suggesting a potential skin application for antimelanogenic treatments and confirming the key role of nanotechnological approaches to maximize plant extract’s potentialities. MDPI 2022-07-14 /pmc/articles/PMC9320162/ /pubmed/35890482 http://dx.doi.org/10.3390/plants11141849 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pintus, Francesca
Floris, Sonia
Fais, Antonella
Era, Benedetta
Porcedda, Clara
Tuberoso, Carlo Ignazio Giovanni
Caddeo, Carla
Euphorbia characias Extract: Inhibition of Skin Aging-Related Enzymes and Nanoformulation
title Euphorbia characias Extract: Inhibition of Skin Aging-Related Enzymes and Nanoformulation
title_full Euphorbia characias Extract: Inhibition of Skin Aging-Related Enzymes and Nanoformulation
title_fullStr Euphorbia characias Extract: Inhibition of Skin Aging-Related Enzymes and Nanoformulation
title_full_unstemmed Euphorbia characias Extract: Inhibition of Skin Aging-Related Enzymes and Nanoformulation
title_short Euphorbia characias Extract: Inhibition of Skin Aging-Related Enzymes and Nanoformulation
title_sort euphorbia characias extract: inhibition of skin aging-related enzymes and nanoformulation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320162/
https://www.ncbi.nlm.nih.gov/pubmed/35890482
http://dx.doi.org/10.3390/plants11141849
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