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Euphorbia characias Extract: Inhibition of Skin Aging-Related Enzymes and Nanoformulation
Plant extracts have long served as important sources of bioactive compounds, and they are currently the focus of extensive research in the development of novel preventive and therapeutic strategies. However, their health benefits are often limited by low bioavailability. Nanoparticle delivery system...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320162/ https://www.ncbi.nlm.nih.gov/pubmed/35890482 http://dx.doi.org/10.3390/plants11141849 |
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author | Pintus, Francesca Floris, Sonia Fais, Antonella Era, Benedetta Porcedda, Clara Tuberoso, Carlo Ignazio Giovanni Caddeo, Carla |
author_facet | Pintus, Francesca Floris, Sonia Fais, Antonella Era, Benedetta Porcedda, Clara Tuberoso, Carlo Ignazio Giovanni Caddeo, Carla |
author_sort | Pintus, Francesca |
collection | PubMed |
description | Plant extracts have long served as important sources of bioactive compounds, and they are currently the focus of extensive research in the development of novel preventive and therapeutic strategies. However, their health benefits are often limited by low bioavailability. Nanoparticle delivery systems can represent a solution to such limitations. Euphorbia characias is a Mediterranean shrub known to have biological activities, such as inhibiting tyrosinase and showing a potential role as a skin-whitening agent. In this study, an ethanolic extract from E. characias leaves was tested for its inhibitory activity on skin-related enzymes, such as elastase, collagenase, and hyaluronidase, and for sun protection factors. Moreover, the extract was formulated in phospholipid vesicles to improve its local bioavailability and applicability. The vesicles were characterized by size, surface charge, storage stability, and entrapment efficiency. The nanoformulation was also evaluated for antioxidant activity and assayed for cytocompatibility and anti-tyrosinase activity in melanoma cells. Our findings demonstrated that the extract has a photo-protective effect and enzyme-inhibitory properties. E. characias nanoformulation was also cytocompatible and improved the extract’s activity in the cells, suggesting a potential skin application for antimelanogenic treatments and confirming the key role of nanotechnological approaches to maximize plant extract’s potentialities. |
format | Online Article Text |
id | pubmed-9320162 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93201622022-07-27 Euphorbia characias Extract: Inhibition of Skin Aging-Related Enzymes and Nanoformulation Pintus, Francesca Floris, Sonia Fais, Antonella Era, Benedetta Porcedda, Clara Tuberoso, Carlo Ignazio Giovanni Caddeo, Carla Plants (Basel) Article Plant extracts have long served as important sources of bioactive compounds, and they are currently the focus of extensive research in the development of novel preventive and therapeutic strategies. However, their health benefits are often limited by low bioavailability. Nanoparticle delivery systems can represent a solution to such limitations. Euphorbia characias is a Mediterranean shrub known to have biological activities, such as inhibiting tyrosinase and showing a potential role as a skin-whitening agent. In this study, an ethanolic extract from E. characias leaves was tested for its inhibitory activity on skin-related enzymes, such as elastase, collagenase, and hyaluronidase, and for sun protection factors. Moreover, the extract was formulated in phospholipid vesicles to improve its local bioavailability and applicability. The vesicles were characterized by size, surface charge, storage stability, and entrapment efficiency. The nanoformulation was also evaluated for antioxidant activity and assayed for cytocompatibility and anti-tyrosinase activity in melanoma cells. Our findings demonstrated that the extract has a photo-protective effect and enzyme-inhibitory properties. E. characias nanoformulation was also cytocompatible and improved the extract’s activity in the cells, suggesting a potential skin application for antimelanogenic treatments and confirming the key role of nanotechnological approaches to maximize plant extract’s potentialities. MDPI 2022-07-14 /pmc/articles/PMC9320162/ /pubmed/35890482 http://dx.doi.org/10.3390/plants11141849 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Pintus, Francesca Floris, Sonia Fais, Antonella Era, Benedetta Porcedda, Clara Tuberoso, Carlo Ignazio Giovanni Caddeo, Carla Euphorbia characias Extract: Inhibition of Skin Aging-Related Enzymes and Nanoformulation |
title | Euphorbia characias Extract: Inhibition of Skin Aging-Related Enzymes and Nanoformulation |
title_full | Euphorbia characias Extract: Inhibition of Skin Aging-Related Enzymes and Nanoformulation |
title_fullStr | Euphorbia characias Extract: Inhibition of Skin Aging-Related Enzymes and Nanoformulation |
title_full_unstemmed | Euphorbia characias Extract: Inhibition of Skin Aging-Related Enzymes and Nanoformulation |
title_short | Euphorbia characias Extract: Inhibition of Skin Aging-Related Enzymes and Nanoformulation |
title_sort | euphorbia characias extract: inhibition of skin aging-related enzymes and nanoformulation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320162/ https://www.ncbi.nlm.nih.gov/pubmed/35890482 http://dx.doi.org/10.3390/plants11141849 |
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