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Prediction of Intraparenchymal Hemorrhage Progression and Neurologic Outcome in Traumatic Brain Injury Patients Using Radiomics Score and Clinical Parameters

(1) Background: Radiomics analysis of spontaneous intracerebral hemorrhages on computed tomography (CT) images has been proven effective in predicting hematoma expansion and poor neurologic outcome. In contrast, there is limited evidence on its predictive abilities for traumatic intraparenchymal hem...

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Autores principales: Shih, Yun-Ju, Liu, Yan-Lin, Chen, Jeon-Hor, Ho, Chung-Han, Yang, Cheng-Chun, Chen, Tai-Yuan, Wu, Te-Chang, Ko, Ching-Chung, Zhou, Jonathan T., Zhang, Yang, Su, Min-Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320220/
https://www.ncbi.nlm.nih.gov/pubmed/35885581
http://dx.doi.org/10.3390/diagnostics12071677
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author Shih, Yun-Ju
Liu, Yan-Lin
Chen, Jeon-Hor
Ho, Chung-Han
Yang, Cheng-Chun
Chen, Tai-Yuan
Wu, Te-Chang
Ko, Ching-Chung
Zhou, Jonathan T.
Zhang, Yang
Su, Min-Ying
author_facet Shih, Yun-Ju
Liu, Yan-Lin
Chen, Jeon-Hor
Ho, Chung-Han
Yang, Cheng-Chun
Chen, Tai-Yuan
Wu, Te-Chang
Ko, Ching-Chung
Zhou, Jonathan T.
Zhang, Yang
Su, Min-Ying
author_sort Shih, Yun-Ju
collection PubMed
description (1) Background: Radiomics analysis of spontaneous intracerebral hemorrhages on computed tomography (CT) images has been proven effective in predicting hematoma expansion and poor neurologic outcome. In contrast, there is limited evidence on its predictive abilities for traumatic intraparenchymal hemorrhage (IPH). (2) Methods: A retrospective analysis of 107 traumatic IPH patients was conducted. Among them, 45 patients (42.1%) showed hemorrhagic progression of contusion (HPC) and 51 patients (47.7%) had poor neurological outcome. The IPH on the initial CT was manually segmented for radiomics analysis. After feature extraction, selection and repeatability evaluation, several machine learning algorithms were used to derive radiomics scores (R-scores) for the prediction of HPC and poor neurologic outcome. (3) Results: The AUCs for R-scores alone to predict HPC and poor neurologic outcome were 0.76 and 0.81, respectively. Clinical parameters were used to build comparison models. For HPC prediction, variables including age, multiple IPH, subdural hemorrhage, Injury Severity Score (ISS), international normalized ratio (INR) and IPH volume taken together yielded an AUC of 0.74, which was significantly (p = 0.022) increased to 0.83 after incorporation of the R-score in a combined model. For poor neurologic outcome prediction, clinical variables of age, Glasgow Coma Scale, ISS, INR and IPH volume showed high predictability with an AUC of 0.92, and further incorporation of the R-score did not improve the AUC. (4) Conclusion: The results suggest that radiomics analysis of IPH lesions on initial CT images has the potential to predict HPC and poor neurologic outcome in traumatic IPH patients. The clinical and R-score combined model further improves the performance of HPC prediction.
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spelling pubmed-93202202022-07-27 Prediction of Intraparenchymal Hemorrhage Progression and Neurologic Outcome in Traumatic Brain Injury Patients Using Radiomics Score and Clinical Parameters Shih, Yun-Ju Liu, Yan-Lin Chen, Jeon-Hor Ho, Chung-Han Yang, Cheng-Chun Chen, Tai-Yuan Wu, Te-Chang Ko, Ching-Chung Zhou, Jonathan T. Zhang, Yang Su, Min-Ying Diagnostics (Basel) Article (1) Background: Radiomics analysis of spontaneous intracerebral hemorrhages on computed tomography (CT) images has been proven effective in predicting hematoma expansion and poor neurologic outcome. In contrast, there is limited evidence on its predictive abilities for traumatic intraparenchymal hemorrhage (IPH). (2) Methods: A retrospective analysis of 107 traumatic IPH patients was conducted. Among them, 45 patients (42.1%) showed hemorrhagic progression of contusion (HPC) and 51 patients (47.7%) had poor neurological outcome. The IPH on the initial CT was manually segmented for radiomics analysis. After feature extraction, selection and repeatability evaluation, several machine learning algorithms were used to derive radiomics scores (R-scores) for the prediction of HPC and poor neurologic outcome. (3) Results: The AUCs for R-scores alone to predict HPC and poor neurologic outcome were 0.76 and 0.81, respectively. Clinical parameters were used to build comparison models. For HPC prediction, variables including age, multiple IPH, subdural hemorrhage, Injury Severity Score (ISS), international normalized ratio (INR) and IPH volume taken together yielded an AUC of 0.74, which was significantly (p = 0.022) increased to 0.83 after incorporation of the R-score in a combined model. For poor neurologic outcome prediction, clinical variables of age, Glasgow Coma Scale, ISS, INR and IPH volume showed high predictability with an AUC of 0.92, and further incorporation of the R-score did not improve the AUC. (4) Conclusion: The results suggest that radiomics analysis of IPH lesions on initial CT images has the potential to predict HPC and poor neurologic outcome in traumatic IPH patients. The clinical and R-score combined model further improves the performance of HPC prediction. MDPI 2022-07-10 /pmc/articles/PMC9320220/ /pubmed/35885581 http://dx.doi.org/10.3390/diagnostics12071677 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Shih, Yun-Ju
Liu, Yan-Lin
Chen, Jeon-Hor
Ho, Chung-Han
Yang, Cheng-Chun
Chen, Tai-Yuan
Wu, Te-Chang
Ko, Ching-Chung
Zhou, Jonathan T.
Zhang, Yang
Su, Min-Ying
Prediction of Intraparenchymal Hemorrhage Progression and Neurologic Outcome in Traumatic Brain Injury Patients Using Radiomics Score and Clinical Parameters
title Prediction of Intraparenchymal Hemorrhage Progression and Neurologic Outcome in Traumatic Brain Injury Patients Using Radiomics Score and Clinical Parameters
title_full Prediction of Intraparenchymal Hemorrhage Progression and Neurologic Outcome in Traumatic Brain Injury Patients Using Radiomics Score and Clinical Parameters
title_fullStr Prediction of Intraparenchymal Hemorrhage Progression and Neurologic Outcome in Traumatic Brain Injury Patients Using Radiomics Score and Clinical Parameters
title_full_unstemmed Prediction of Intraparenchymal Hemorrhage Progression and Neurologic Outcome in Traumatic Brain Injury Patients Using Radiomics Score and Clinical Parameters
title_short Prediction of Intraparenchymal Hemorrhage Progression and Neurologic Outcome in Traumatic Brain Injury Patients Using Radiomics Score and Clinical Parameters
title_sort prediction of intraparenchymal hemorrhage progression and neurologic outcome in traumatic brain injury patients using radiomics score and clinical parameters
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320220/
https://www.ncbi.nlm.nih.gov/pubmed/35885581
http://dx.doi.org/10.3390/diagnostics12071677
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