A ferrocene-containing nucleoside analogue targets DNA replication in pancreatic cancer cells

Pancreatic ductal adenocarcinoma (PDAC) is a disease that remains refractory to existing treatments including the nucleoside analogue gemcitabine. In the current study we demonstrate that an organometallic nucleoside analogue, the ferronucleoside 1-(S,R(p)), is cytotoxic in a panel of PDAC cell line...

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Detalles Bibliográficos
Autores principales: Rana, Marium, Perotti, Alessio, Bisset, Lucy M, Smith, James D, Lamden, Emma, Khan, Zahra, Ismail, Media K, Ellis, Katherine, Armstrong, Katie A, Hodder, Samantha L, Bertoli, Cosetta, Meneguello, Leticia, de Bruin, Robertus A M, Morris, Joanna R, Romero-Canelon, Isolda, Tucker, James H R, Hodges, Nikolas J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320222/
https://www.ncbi.nlm.nih.gov/pubmed/35689667
http://dx.doi.org/10.1093/mtomcs/mfac041

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