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The NEL Family of Bacterial E3 Ubiquitin Ligases

Some pathogenic or symbiotic Gram-negative bacteria can manipulate the ubiquitination system of the eukaryotic host cell using a variety of strategies. Members of the genera Salmonella, Shigella, Sinorhizobium, and Ralstonia, among others, express E3 ubiquitin ligases that belong to the NEL family....

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Detalles Bibliográficos
Autores principales: Bullones-Bolaños, Andrea, Bernal-Bayard, Joaquín, Ramos-Morales, Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320238/
https://www.ncbi.nlm.nih.gov/pubmed/35887072
http://dx.doi.org/10.3390/ijms23147725
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author Bullones-Bolaños, Andrea
Bernal-Bayard, Joaquín
Ramos-Morales, Francisco
author_facet Bullones-Bolaños, Andrea
Bernal-Bayard, Joaquín
Ramos-Morales, Francisco
author_sort Bullones-Bolaños, Andrea
collection PubMed
description Some pathogenic or symbiotic Gram-negative bacteria can manipulate the ubiquitination system of the eukaryotic host cell using a variety of strategies. Members of the genera Salmonella, Shigella, Sinorhizobium, and Ralstonia, among others, express E3 ubiquitin ligases that belong to the NEL family. These bacteria use type III secretion systems to translocate these proteins into host cells, where they will find their targets. In this review, we first introduce type III secretion systems and the ubiquitination process and consider the various ways bacteria use to alter the ubiquitin ligation machinery. We then focus on the members of the NEL family, their expression, translocation, and subcellular localization in the host cell, and we review what is known about the structure of these proteins, their function in virulence or symbiosis, and their specific targets.
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spelling pubmed-93202382022-07-27 The NEL Family of Bacterial E3 Ubiquitin Ligases Bullones-Bolaños, Andrea Bernal-Bayard, Joaquín Ramos-Morales, Francisco Int J Mol Sci Review Some pathogenic or symbiotic Gram-negative bacteria can manipulate the ubiquitination system of the eukaryotic host cell using a variety of strategies. Members of the genera Salmonella, Shigella, Sinorhizobium, and Ralstonia, among others, express E3 ubiquitin ligases that belong to the NEL family. These bacteria use type III secretion systems to translocate these proteins into host cells, where they will find their targets. In this review, we first introduce type III secretion systems and the ubiquitination process and consider the various ways bacteria use to alter the ubiquitin ligation machinery. We then focus on the members of the NEL family, their expression, translocation, and subcellular localization in the host cell, and we review what is known about the structure of these proteins, their function in virulence or symbiosis, and their specific targets. MDPI 2022-07-13 /pmc/articles/PMC9320238/ /pubmed/35887072 http://dx.doi.org/10.3390/ijms23147725 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bullones-Bolaños, Andrea
Bernal-Bayard, Joaquín
Ramos-Morales, Francisco
The NEL Family of Bacterial E3 Ubiquitin Ligases
title The NEL Family of Bacterial E3 Ubiquitin Ligases
title_full The NEL Family of Bacterial E3 Ubiquitin Ligases
title_fullStr The NEL Family of Bacterial E3 Ubiquitin Ligases
title_full_unstemmed The NEL Family of Bacterial E3 Ubiquitin Ligases
title_short The NEL Family of Bacterial E3 Ubiquitin Ligases
title_sort nel family of bacterial e3 ubiquitin ligases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320238/
https://www.ncbi.nlm.nih.gov/pubmed/35887072
http://dx.doi.org/10.3390/ijms23147725
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