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The NEL Family of Bacterial E3 Ubiquitin Ligases
Some pathogenic or symbiotic Gram-negative bacteria can manipulate the ubiquitination system of the eukaryotic host cell using a variety of strategies. Members of the genera Salmonella, Shigella, Sinorhizobium, and Ralstonia, among others, express E3 ubiquitin ligases that belong to the NEL family....
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320238/ https://www.ncbi.nlm.nih.gov/pubmed/35887072 http://dx.doi.org/10.3390/ijms23147725 |
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author | Bullones-Bolaños, Andrea Bernal-Bayard, Joaquín Ramos-Morales, Francisco |
author_facet | Bullones-Bolaños, Andrea Bernal-Bayard, Joaquín Ramos-Morales, Francisco |
author_sort | Bullones-Bolaños, Andrea |
collection | PubMed |
description | Some pathogenic or symbiotic Gram-negative bacteria can manipulate the ubiquitination system of the eukaryotic host cell using a variety of strategies. Members of the genera Salmonella, Shigella, Sinorhizobium, and Ralstonia, among others, express E3 ubiquitin ligases that belong to the NEL family. These bacteria use type III secretion systems to translocate these proteins into host cells, where they will find their targets. In this review, we first introduce type III secretion systems and the ubiquitination process and consider the various ways bacteria use to alter the ubiquitin ligation machinery. We then focus on the members of the NEL family, their expression, translocation, and subcellular localization in the host cell, and we review what is known about the structure of these proteins, their function in virulence or symbiosis, and their specific targets. |
format | Online Article Text |
id | pubmed-9320238 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93202382022-07-27 The NEL Family of Bacterial E3 Ubiquitin Ligases Bullones-Bolaños, Andrea Bernal-Bayard, Joaquín Ramos-Morales, Francisco Int J Mol Sci Review Some pathogenic or symbiotic Gram-negative bacteria can manipulate the ubiquitination system of the eukaryotic host cell using a variety of strategies. Members of the genera Salmonella, Shigella, Sinorhizobium, and Ralstonia, among others, express E3 ubiquitin ligases that belong to the NEL family. These bacteria use type III secretion systems to translocate these proteins into host cells, where they will find their targets. In this review, we first introduce type III secretion systems and the ubiquitination process and consider the various ways bacteria use to alter the ubiquitin ligation machinery. We then focus on the members of the NEL family, their expression, translocation, and subcellular localization in the host cell, and we review what is known about the structure of these proteins, their function in virulence or symbiosis, and their specific targets. MDPI 2022-07-13 /pmc/articles/PMC9320238/ /pubmed/35887072 http://dx.doi.org/10.3390/ijms23147725 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Bullones-Bolaños, Andrea Bernal-Bayard, Joaquín Ramos-Morales, Francisco The NEL Family of Bacterial E3 Ubiquitin Ligases |
title | The NEL Family of Bacterial E3 Ubiquitin Ligases |
title_full | The NEL Family of Bacterial E3 Ubiquitin Ligases |
title_fullStr | The NEL Family of Bacterial E3 Ubiquitin Ligases |
title_full_unstemmed | The NEL Family of Bacterial E3 Ubiquitin Ligases |
title_short | The NEL Family of Bacterial E3 Ubiquitin Ligases |
title_sort | nel family of bacterial e3 ubiquitin ligases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320238/ https://www.ncbi.nlm.nih.gov/pubmed/35887072 http://dx.doi.org/10.3390/ijms23147725 |
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