Cargando…

Deletion of the ASFV dUTPase Gene E165R from the Genome of Highly Virulent African Swine Fever Virus Georgia 2010 Does Not Affect Virus Replication or Virulence in Domestic Pigs

African swine fever (ASF) is a frequently lethal disease of domestic and wild swine currently producing a pandemic affecting pig production in Eurasia. The causative agent, ASF virus (ASFV) is a structurally complex virus with a large genome harboring over 150 genes. One of them, E165R, encodes for...

Descripción completa

Detalles Bibliográficos
Autores principales:	Vuono, Elizabeth A., Ramirez-Medina, Elizabeth, Pruitt, Sarah, Rai, Ayushi, Espinoza, Nallely, Silva, Ediane, Velazquez-Salinas, Lauro, Gladue, Douglas P., Borca, Manuel V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320246/ https://www.ncbi.nlm.nih.gov/pubmed/35891389 http://dx.doi.org/10.3390/v14071409

Ejemplares similares

Evaluation of an ASFV RNA Helicase Gene A859L for Virus Replication and Swine Virulence
por: Ramirez-Medina, Elizabeth, et al.
Publicado: (2021)

ASFV Gene A151R Is Involved in the Process of Virulence in Domestic Swine
por: Ramirez-Medina, Elizabeth, et al.
Publicado: (2022)

Evaluation of the Function of the ASFV KP177R Gene, Encoding for Structural Protein p22, in the Process of Virus Replication and in Swine Virulence
por: Vuono, Elizabeth A., et al.
Publicado: (2021)

Deletion of the EP296R Gene from the Genome of Highly Virulent African Swine Fever Virus Georgia 2010 Does Not Affect Virus Replication or Virulence in Domestic Pigs
por: Vuono, Elizabeth A., et al.
Publicado: (2022)

Evaluation of the Function of ASFV Gene E66L in the Process of Virus Replication and Virulence in Swine
por: Ramirez-Medina, Elizabeth, et al.
Publicado: (2023)

Deletion of African Swine Fever Virus Histone-like Protein, A104R from the Georgia Isolate Drastically Reduces Virus Virulence in Domestic Pigs
por: Ramirez-Medina, Elizabeth, et al.
Publicado: (2022)

Deletion of an African Swine Fever Virus ATP-Dependent RNA Helicase QP509L from the Highly Virulent Georgia 2010 Strain Does Not Affect Replication or Virulence
por: Ramirez-Medina, Elizabeth, et al.
Publicado: (2022)

ASF Vaccine Candidate ASFV-G-∆I177L Does Not Exhibit Residual Virulence in Long-Term Clinical Studies
por: Borca, Manuel V., et al.
Publicado: (2023)

Evaluation in Swine of a Recombinant Georgia 2010 African Swine Fever Virus Lacking the I8L Gene
por: Vuono, Elizabeth, et al.
Publicado: (2020)

ASFV-G-∆I177L as an Effective Oral Nasal Vaccine against the Eurasia Strain of Africa Swine Fever
por: Borca, Manuel V., et al.
Publicado: (2021)

The C962R ORF of African Swine Fever Strain Georgia Is Non-Essential and Not Required for Virulence in Swine
por: Ramirez-Medina, Elizabeth., et al.
Publicado: (2020)

Differential Effect of the Deletion of African Swine Fever Virus Virulence-Associated Genes in the Induction of Attenuation of the Highly Virulent Georgia Strain
por: Ramirez-Medina, Elizabeth, et al.
Publicado: (2019)

The Presence of Virus Neutralizing Antibodies Is Highly Associated with Protection against Virulent Challenge in Domestic Pigs Immunized with ASFV live Attenuated Vaccine Candidates
por: Silva, Ediane B., et al.
Publicado: (2022)

Deletion of the H240R Gene in African Swine Fever Virus Partially Reduces Virus Virulence in Swine
por: Ramirez-Medina, Elizabeth, et al.
Publicado: (2023)

Development and In Vivo Evaluation of a MGF110-1L Deletion Mutant in African Swine Fever Strain Georgia
por: Ramirez-Medina, Elizabeth, et al.
Publicado: (2021)

Deletion of CD2-like gene from the genome of African swine fever virus strain Georgia does not attenuate virulence in swine
por: Borca, Manuel V., et al.
Publicado: (2020)

SERTA Domain Containing Protein 1 (SERTAD1) Interacts with Classical Swine Fever Virus Structural Glycoprotein E2, Which Is Involved in Virus Virulence in Swine
por: Vuono, Elizabeth A., et al.
Publicado: (2020)

X69R Is a Non-Essential Gene That, When Deleted from African Swine Fever, Does Not Affect Virulence in Swine
por: Ramirez-Medina, Elizabeth, et al.
Publicado: (2020)

African Swine Fever Vaccine Candidate ASFV-G-ΔI177L Produced in the Swine Macrophage-Derived Cell Line IPKM Remains Genetically Stable and Protective against Homologous Virulent Challenge
por: Borca, Manuel V., et al.
Publicado: (2023)

The MGF360-16R ORF of African Swine Fever Virus Strain Georgia Encodes for a Nonessential Gene That Interacts with Host Proteins SERTAD3 and SDCBP
por: Ramírez-Medina, Elizabeth, et al.
Publicado: (2020)

Deletion of CD2-Like (CD2v) and C-Type Lectin-Like (EP153R) Genes from African Swine Fever Virus Georgia-∆9GL Abrogates Its Effectiveness as an Experimental Vaccine
por: Gladue, Douglas P., et al.
Publicado: (2020)

Development Real-Time PCR Assays to Genetically Differentiate Vaccinated Pigs From Infected Pigs With the Eurasian Strain of African Swine Fever Virus
por: Velazquez-Salinas, Lauro, et al.
Publicado: (2021)

Classical Swine Fever Virus Structural Glycoprotein E2 Interacts with Host Protein ACADM during the Virus Infectious Cycle
por: Vuono, Elizabeth, et al.
Publicado: (2023)

Identification and Characterization of a Novel Epitope of ASFV-Encoded dUTPase by Monoclonal Antibodies
por: Zhang, Shuai, et al.
Publicado: (2021)

Swine Host Protein Coiled-Coil Domain-Containing 115 (CCDC115) Interacts with Classical Swine Fever Virus Structural Glycoprotein E2 during Virus Replication
por: Vuono, Elizabeth A., et al.
Publicado: (2020)

Evaluation in Swine of a Recombinant African Swine Fever Virus Lacking the MGF-360-1L Gene
por: Ramirez-Medina, Elizabeth, et al.
Publicado: (2020)

Identification of a Continuously Stable and Commercially Available Cell Line for the Identification of Infectious African Swine Fever Virus in Clinical Samples
por: Rai, Ayushi, et al.
Publicado: (2020)

Evaluation of the Deletion of the African Swine Fever Virus Gene O174L from the Genome of the Georgia Isolate
por: Ramirez-Medina, Elizabeth, et al.
Publicado: (2023)

Life without dUTPase
por: Kerepesi, Csaba, et al.
Publicado: (2016)

The dUTPase-related gene of bovine immunodeficiency virus is critical for viral replication, despite the lack of dUTPase activity of the encoded protein
por: Voronin, Nickolay, et al.
Publicado: (2014)

Complete Structural Predictions of the Proteome of African Swine Fever Virus Strain Georgia 2007
por: Spinard, Edward, et al.
Publicado: (2022)

The dUTPase Enzyme Is Essential in Mycobacterium smegmatis
por: Pecsi, Ildiko, et al.
Publicado: (2012)

Viral dUTPases: Modulators of Innate Immunity
por: Ariza, Maria Eugenia, et al.
Publicado: (2022)

Molecular Characterization of UL50 (dUTPase) Gene of Bovine Herpes Virus 1
por: Shahin, Farzana, et al.
Publicado: (2023)

Full genome sequence for the African swine fever virus outbreak in the Dominican Republic in 1980
por: Spinard, Edward, et al.
Publicado: (2023)

Homologous Recombination Is Stimulated by a Decrease in dUTPase in Arabidopsis
por: Dubois, Emeline, et al.
Publicado: (2011)

dUTPase: the frequently overlooked enzyme encoded by many retroviruses
por: Hizi, Amnon, et al.
Publicado: (2015)

Enzyme kinetics of dUTPase from the planarian Dugesia ryukyuensis
por: Alam, Md. Shahanoor, et al.
Publicado: (2019)

dUTPase inhibition augments replication defects of 5-Fluorouracil
por: Hagenkort, Anna, et al.
Publicado: (2017)

A Triple Gene-Deleted Pseudorabies Virus-Vectored Subunit PCV2b and CSFV Vaccine Protect Pigs against a Virulent CSFV Challenge
por: Silva, Ediane, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_f481qe5ub83mg62hof3adpt4nh