Cargando…

Molecular Effects of Chronic Exposure to Palmitate in Intestinal Organoids: A New Model to Study Obesity and Diabetes

Intestinal cell dysfunctions involved in obesity and associated diabetes could be correlated with impaired intestinal cell development. To date, the molecular mechanisms underlying these dysfunctions have been poorly investigated because of the lack of a good model for studying obesity. The main aim...

Descripción completa

Detalles Bibliográficos
Autores principales:	Filippello, Agnese, Di Mauro, Stefania, Scamporrino, Alessandra, Torrisi, Sebastiano Alfio, Leggio, Gian Marco, Di Pino, Antonino, Scicali, Roberto, Di Marco, Maurizio, Malaguarnera, Roberta, Purrello, Francesco, Piro, Salvatore
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320247/ https://www.ncbi.nlm.nih.gov/pubmed/35887100 http://dx.doi.org/10.3390/ijms23147751

Ejemplares similares

High Glucose Exposure Impairs L-Cell Differentiation in Intestinal Organoids: Molecular Mechanisms and Clinical Implications
por: Filippello, Agnese, et al.
Publicado: (2021)

Direct Effects of D-Chiro-Inositol on Insulin Signaling and Glucagon Secretion of Pancreatic Alpha Cells
por: Filippello, Agnese, et al.
Publicado: (2020)

Clinical and Molecular Biomarkers for Diagnosis and Staging of NAFLD
por: Di Mauro, Stefania, et al.
Publicado: (2021)

Identification of a New RNA and Protein Integrated Biomarker Panel Associated with Kidney Function Impairment in DKD: Translational Implications
por: Scamporrino, Alessandra, et al.
Publicado: (2023)

Chronic Exposure to Palmitate Impairs Insulin Signaling in an Intestinal L-cell Line: A Possible Shift from GLP-1 to Glucagon Production
por: Filippello, Agnese, et al.
Publicado: (2018)

Mitochondrial RNAs as Potential Biomarkers of Functional Impairment in Diabetic Kidney Disease
por: Di Mauro, Stefania, et al.
Publicado: (2022)

Metformin: When Should We Fear Lactic Acidosis?
por: Di Mauro, Stefania, et al.
Publicado: (2022)

Direct and Indirect Effects of SARS-CoV-2 Pandemic in Subjects with Familial Hypercholesterolemia: A Single Lipid-Center Real-World Evaluation
por: Scicali, Roberto, et al.
Publicado: (2021)

Increased Platelet Reactivity and Proinflammatory Profile Are Associated with Intima–Media Thickness and Arterial Stiffness in Prediabetes
por: Di Marco, Maurizio, et al.
Publicado: (2022)

1 h Postload Glycemia Is Associated with Low Endogenous Secretory Receptor for Advanced Glycation End Product Levels and Early Markers of Cardiovascular Disease
por: Di Pino, Antonino, et al.
Publicado: (2019)

Impaired glucagon suppression and reduced insulin sensitivity in subjects with prediabetes undergoing atorvastatin therapy
por: Urbano, Francesca, et al.
Publicado: (2019)

Atorvastatin but Not Pravastatin Impairs Mitochondrial Function in Human Pancreatic Islets and Rat β-Cells. Direct Effect of Oxidative Stress
por: Urbano, Francesca, et al.
Publicado: (2017)

Author Correction: Atorvastatin but Not Pravastatin Impairs Mitochondrial Function in Human Pancreatic Islets and Rat β-Cells. Direct Effect of Oxidative Stress
por: Urbano, Francesca, et al.
Publicado: (2020)

Update on Diabetic Kidney Disease (DKD): Focus on Non-Albuminuric DKD and Cardiovascular Risk
por: Scilletta, Sabrina, et al.
Publicado: (2023)

Circulating Coding and Long Non-Coding RNAs as Potential Biomarkers of Idiopathic Pulmonary Fibrosis
por: Di Mauro, Stefania, et al.
Publicado: (2020)

Glucagon as a Therapeutic Approach to Severe Hypoglycemia: After 100 Years, Is It Still the Antidote of Insulin?
por: Porcellati, Francesca, et al.
Publicado: (2021)

Analysis of HDL-microRNA panel in heterozygous familial hypercholesterolemia subjects with LDL receptor null or defective mutation
por: Scicali, Roberto, et al.
Publicado: (2019)

An Uncharacterised lncRNA Coded by the ASAP1 Locus Is Downregulated in Serum of Type 2 Diabetes Mellitus Patients
por: Barbagallo, Cristina, et al.
Publicado: (2023)

Coffee Restores Expression of lncRNAs Involved in Steatosis and Fibrosis in a Mouse Model of NAFLD
por: Di Mauro, Stefania, et al.
Publicado: (2021)

Serum coding and non‐coding RNAs as biomarkers of NAFLD and fibrosis severity
por: Di Mauro, Stefania, et al.
Publicado: (2019)

Controlling Nutritional Status (CONUT) Score as a Potential Prognostic Indicator of In-Hospital Mortality, Sepsis and Length of Stay in an Internal Medicine Department
por: Miano, Nicoletta, et al.
Publicado: (2023)

May statins and PCSK9 inhibitors be protective from COVID-19 in familial hypercholesterolemia subjects?
por: Scicali, Roberto, et al.
Publicado: (2020)

Effect of PCSK9 inhibitors on pulse wave velocity and monocyte-to-HDL-cholesterol ratio in familial hypercholesterolemia subjects: results from a single-lipid-unit real-life setting
por: Scicali, Roberto, et al.
Publicado: (2021)

Chronic Exposure to GLP-1 Increases GLP-1 Synthesis and Release in a Pancreatic Alpha Cell Line (α-TC1): Evidence of a Direct Effect of GLP-1 on Pancreatic Alpha Cells
por: Piro, Salvatore, et al.
Publicado: (2014)

Dysregulation of miR-15a-5p, miR-497a-5p and miR-511-5p Is Associated with Modulation of BDNF and FKBP5 in Brain Areas of PTSD-Related Susceptible and Resilient Mice
por: Maurel, Oriana Maria, et al.
Publicado: (2021)

Therapeutic Challenges of Post-traumatic Stress Disorder: Focus on the Dopaminergic System
por: Torrisi, Sebastiano Alfio, et al.
Publicado: (2019)

Management of Statin Intolerant Patients in the Era of Novel Lipid Lowering Therapies: A Critical Approach in Clinical Practice
por: Bosco, Giosiana, et al.
Publicado: (2023)

Pathophysiological, Molecular and Therapeutic Issues of Nonalcoholic Fatty Liver Disease: An Overview
por: Marchisello, Simona, et al.
Publicado: (2019)

Direct and indirect effects of SARS-CoV-2 pandemic in subjects with familial hypercholesterolemia: A single lipid-center real-world evaluation
por: Scicali, R., et al.
Publicado: (2022)

Analysis of Arterial Stiffness and Sexual Function after Adding on PCSK9 Inhibitor Treatment in Male Patients with Familial Hypercholesterolemia: A Single Lipid Center Real-World Experience
por: Scicali, Roberto, et al.
Publicado: (2020)

Pharmacological and Genetic Evidence of Dopamine Receptor 3-Mediated Vasoconstriction in Isolated Mouse Aorta
por: Zingales, Veronica, et al.
Publicado: (2021)

Is COVID-19 All That Glitters?
por: Spampinato, Salvatore, et al.
Publicado: (2023)

Indirect Effects of the COVID-19 Pandemic on In-Hospital Outcomes among Internal Medicine Departments: A Double-Center Retrospective Study
por: Di Marco, Maurizio, et al.
Publicado: (2023)

Buspirone Counteracts MK-801-Induced Schizophrenia-Like Phenotypes through Dopamine D(3) Receptor Blockade
por: Torrisi, Sebastiano Alfio, et al.
Publicado: (2017)

Update on pre-diabetes: Focus on diagnostic criteria and cardiovascular risk
por: Di Pino, Antonino, et al.
Publicado: (2016)

Effects of Lipid Lowering Therapy Optimization by PCSK9 Inhibitors on Circulating CD34+ Cells and Pulse Wave Velocity in Familial Hypercholesterolemia Subjects without Atherosclerotic Cardiovascular Disease: Real-World Data from Two Lipid Units
por: Scicali, Roberto, et al.
Publicado: (2022)

Retinal biomarkers and pharmacological targets for Hermansky-Pudlak syndrome 7
por: Romano, Giovanni Luca, et al.
Publicado: (2020)

Thyroid Cancer and Circadian Clock Disruption
por: Malaguarnera, Roberta, et al.
Publicado: (2020)

Effects of PCSK9 inhibitors on HDL cholesterol efflux and serum cholesterol loading capacity in familial hypercholesterolemia subjects: a multi-lipid-center real-world evaluation
por: Palumbo, Marcella, et al.
Publicado: (2022)

PCSK9 Plasma Levels Are Associated with Mechanical Vascular Impairment in Familial Hypercholesterolemia Subjects without a History of Atherosclerotic Cardiovascular Disease: Results of Six-Month Add-On PCSK9 Inhibitor Therapy
por: Toscano, Arianna, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_vuih4gkul70op2qg5kk67mf7e4