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Fetal Fibronectin and Cervical Length as Predictors of Spontaneous Onset of Labour and Delivery in Term Pregnancies
(1) Objective: This study aimed to determine whether qualitative fetal fibronectin and transvaginal sonographic measurement of cervical length are effective in predicting delivery in term pregnancies within 5 days of the test. (2) Methods: We examined 268 women with singleton pregnancies presenting...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320260/ https://www.ncbi.nlm.nih.gov/pubmed/35885874 http://dx.doi.org/10.3390/healthcare10071349 |
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author | Grab, Delia Doroftei, Bogdan Grigore, Mihaela Nicolaiciuc, Ovidiu Sebastian Anton, Sorana Caterina Simionescu, Gabriela Maftei, Radu Bolota, Maria Ilea, Ciprian Costachescu, Gabriel Anton, Emil |
author_facet | Grab, Delia Doroftei, Bogdan Grigore, Mihaela Nicolaiciuc, Ovidiu Sebastian Anton, Sorana Caterina Simionescu, Gabriela Maftei, Radu Bolota, Maria Ilea, Ciprian Costachescu, Gabriel Anton, Emil |
author_sort | Grab, Delia |
collection | PubMed |
description | (1) Objective: This study aimed to determine whether qualitative fetal fibronectin and transvaginal sonographic measurement of cervical length are effective in predicting delivery in term pregnancies within 5 days of the test. (2) Methods: We examined 268 women with singleton pregnancies presenting themselves at 37(+0)–40(+4) weeks (median 38 weeks + 1 day) of gestation with irregular and painful uterine contractions, intact membranes and cervical dilatation less than 2 cm. All women were admitted to hospital up to 72 h after birth. On admission, a qualitative fetal fibronectin test was performed in cervicovaginal secretions and transvaginal sonographic measurement of cervical length was carried out. The primary outcome measure was delivery within 5 days of presentation. RESULTS: Among the women who delivered within 5 days after admission, 65.2% had positive fFN assessment, 43.5% had cervical length below 26 mm, 52.2% had the age > 32.5 years, 34.8% were nulliparous and 56.5% had gestational age ≥ 275 days. Logistic regression analysis demonstrated that significant contributors to the prediction of delivery within 5 days were fibronectin positivity, cervical length ≤ 26 mm, maternal age > 32.5 years and gestational age ≥ 275 days, with no significant contribution from parity. (3) Conclusions: Qualitative fetal fibronectin test and transvaginal cervical length measurement in term pregnancies are useful tests for predicting spontaneous onset of labour within 5 days. It helps women and healthcare providers to determine the optimum time for hospital admission. |
format | Online Article Text |
id | pubmed-9320260 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93202602022-07-27 Fetal Fibronectin and Cervical Length as Predictors of Spontaneous Onset of Labour and Delivery in Term Pregnancies Grab, Delia Doroftei, Bogdan Grigore, Mihaela Nicolaiciuc, Ovidiu Sebastian Anton, Sorana Caterina Simionescu, Gabriela Maftei, Radu Bolota, Maria Ilea, Ciprian Costachescu, Gabriel Anton, Emil Healthcare (Basel) Article (1) Objective: This study aimed to determine whether qualitative fetal fibronectin and transvaginal sonographic measurement of cervical length are effective in predicting delivery in term pregnancies within 5 days of the test. (2) Methods: We examined 268 women with singleton pregnancies presenting themselves at 37(+0)–40(+4) weeks (median 38 weeks + 1 day) of gestation with irregular and painful uterine contractions, intact membranes and cervical dilatation less than 2 cm. All women were admitted to hospital up to 72 h after birth. On admission, a qualitative fetal fibronectin test was performed in cervicovaginal secretions and transvaginal sonographic measurement of cervical length was carried out. The primary outcome measure was delivery within 5 days of presentation. RESULTS: Among the women who delivered within 5 days after admission, 65.2% had positive fFN assessment, 43.5% had cervical length below 26 mm, 52.2% had the age > 32.5 years, 34.8% were nulliparous and 56.5% had gestational age ≥ 275 days. Logistic regression analysis demonstrated that significant contributors to the prediction of delivery within 5 days were fibronectin positivity, cervical length ≤ 26 mm, maternal age > 32.5 years and gestational age ≥ 275 days, with no significant contribution from parity. (3) Conclusions: Qualitative fetal fibronectin test and transvaginal cervical length measurement in term pregnancies are useful tests for predicting spontaneous onset of labour within 5 days. It helps women and healthcare providers to determine the optimum time for hospital admission. MDPI 2022-07-20 /pmc/articles/PMC9320260/ /pubmed/35885874 http://dx.doi.org/10.3390/healthcare10071349 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Grab, Delia Doroftei, Bogdan Grigore, Mihaela Nicolaiciuc, Ovidiu Sebastian Anton, Sorana Caterina Simionescu, Gabriela Maftei, Radu Bolota, Maria Ilea, Ciprian Costachescu, Gabriel Anton, Emil Fetal Fibronectin and Cervical Length as Predictors of Spontaneous Onset of Labour and Delivery in Term Pregnancies |
title | Fetal Fibronectin and Cervical Length as Predictors of Spontaneous Onset of Labour and Delivery in Term Pregnancies |
title_full | Fetal Fibronectin and Cervical Length as Predictors of Spontaneous Onset of Labour and Delivery in Term Pregnancies |
title_fullStr | Fetal Fibronectin and Cervical Length as Predictors of Spontaneous Onset of Labour and Delivery in Term Pregnancies |
title_full_unstemmed | Fetal Fibronectin and Cervical Length as Predictors of Spontaneous Onset of Labour and Delivery in Term Pregnancies |
title_short | Fetal Fibronectin and Cervical Length as Predictors of Spontaneous Onset of Labour and Delivery in Term Pregnancies |
title_sort | fetal fibronectin and cervical length as predictors of spontaneous onset of labour and delivery in term pregnancies |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320260/ https://www.ncbi.nlm.nih.gov/pubmed/35885874 http://dx.doi.org/10.3390/healthcare10071349 |
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