Cargando…

Aberrated Multidimensional EEG Characteristics in Patients with Generalized Anxiety Disorder: A Machine-Learning Based Analysis Framework

Although increasing evidences support the notion that psychiatric disorders are associated with abnormal communication between brain regions, scattered studies have investigated brain electrophysiological disconnectivity of patients with generalized anxiety disorder (GAD). To this end, this study in...

Descripción completa

Detalles Bibliográficos
Autores principales: Shen, Zhongxia, Li, Gang, Fang, Jiaqi, Zhong, Hongyang, Wang, Jie, Sun, Yu, Shen, Xinhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320264/
https://www.ncbi.nlm.nih.gov/pubmed/35891100
http://dx.doi.org/10.3390/s22145420
_version_ 1784755750674890752
author Shen, Zhongxia
Li, Gang
Fang, Jiaqi
Zhong, Hongyang
Wang, Jie
Sun, Yu
Shen, Xinhua
author_facet Shen, Zhongxia
Li, Gang
Fang, Jiaqi
Zhong, Hongyang
Wang, Jie
Sun, Yu
Shen, Xinhua
author_sort Shen, Zhongxia
collection PubMed
description Although increasing evidences support the notion that psychiatric disorders are associated with abnormal communication between brain regions, scattered studies have investigated brain electrophysiological disconnectivity of patients with generalized anxiety disorder (GAD). To this end, this study intends to develop an analysis framework for automatic GAD detection through incorporating multidimensional EEG feature extraction and machine learning techniques. Specifically, resting-state EEG signals with a duration of 10 min were obtained from 45 patients with GAD and 36 healthy controls (HC). Then, an analysis framework of multidimensional EEG characteristics (including univariate power spectral density (PSD) and fuzzy entropy (FE), and multivariate functional connectivity (FC), which can decode the EEG information from three different dimensions) were introduced for extracting aberrated multidimensional EEG features via statistical inter-group comparisons. These aberrated features were subsequently fused and fed into three previously validated machine learning methods to evaluate classification performance for automatic patient detection. We showed that patients exhibited a significant increase in beta rhythm and decrease in alpha1 rhythm of PSD, together with the reduced long-range FC between frontal and other brain areas in all frequency bands. Moreover, these aberrated features contributed to a very good classification performance with 97.83 ± 0.40% of accuracy, 97.55 ± 0.31% of sensitivity, 97.78 ± 0.36% of specificity, and 97.95 ± 0.17% of F1. These findings corroborate previous hypothesis of disconnectivity in psychiatric disorders and further shed light on distribution patterns of aberrant spatio-spectral EEG characteristics, which may lead to potential application of automatic diagnosis of GAD.
format Online
Article
Text
id pubmed-9320264
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-93202642022-07-27 Aberrated Multidimensional EEG Characteristics in Patients with Generalized Anxiety Disorder: A Machine-Learning Based Analysis Framework Shen, Zhongxia Li, Gang Fang, Jiaqi Zhong, Hongyang Wang, Jie Sun, Yu Shen, Xinhua Sensors (Basel) Article Although increasing evidences support the notion that psychiatric disorders are associated with abnormal communication between brain regions, scattered studies have investigated brain electrophysiological disconnectivity of patients with generalized anxiety disorder (GAD). To this end, this study intends to develop an analysis framework for automatic GAD detection through incorporating multidimensional EEG feature extraction and machine learning techniques. Specifically, resting-state EEG signals with a duration of 10 min were obtained from 45 patients with GAD and 36 healthy controls (HC). Then, an analysis framework of multidimensional EEG characteristics (including univariate power spectral density (PSD) and fuzzy entropy (FE), and multivariate functional connectivity (FC), which can decode the EEG information from three different dimensions) were introduced for extracting aberrated multidimensional EEG features via statistical inter-group comparisons. These aberrated features were subsequently fused and fed into three previously validated machine learning methods to evaluate classification performance for automatic patient detection. We showed that patients exhibited a significant increase in beta rhythm and decrease in alpha1 rhythm of PSD, together with the reduced long-range FC between frontal and other brain areas in all frequency bands. Moreover, these aberrated features contributed to a very good classification performance with 97.83 ± 0.40% of accuracy, 97.55 ± 0.31% of sensitivity, 97.78 ± 0.36% of specificity, and 97.95 ± 0.17% of F1. These findings corroborate previous hypothesis of disconnectivity in psychiatric disorders and further shed light on distribution patterns of aberrant spatio-spectral EEG characteristics, which may lead to potential application of automatic diagnosis of GAD. MDPI 2022-07-20 /pmc/articles/PMC9320264/ /pubmed/35891100 http://dx.doi.org/10.3390/s22145420 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Shen, Zhongxia
Li, Gang
Fang, Jiaqi
Zhong, Hongyang
Wang, Jie
Sun, Yu
Shen, Xinhua
Aberrated Multidimensional EEG Characteristics in Patients with Generalized Anxiety Disorder: A Machine-Learning Based Analysis Framework
title Aberrated Multidimensional EEG Characteristics in Patients with Generalized Anxiety Disorder: A Machine-Learning Based Analysis Framework
title_full Aberrated Multidimensional EEG Characteristics in Patients with Generalized Anxiety Disorder: A Machine-Learning Based Analysis Framework
title_fullStr Aberrated Multidimensional EEG Characteristics in Patients with Generalized Anxiety Disorder: A Machine-Learning Based Analysis Framework
title_full_unstemmed Aberrated Multidimensional EEG Characteristics in Patients with Generalized Anxiety Disorder: A Machine-Learning Based Analysis Framework
title_short Aberrated Multidimensional EEG Characteristics in Patients with Generalized Anxiety Disorder: A Machine-Learning Based Analysis Framework
title_sort aberrated multidimensional eeg characteristics in patients with generalized anxiety disorder: a machine-learning based analysis framework
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320264/
https://www.ncbi.nlm.nih.gov/pubmed/35891100
http://dx.doi.org/10.3390/s22145420
work_keys_str_mv AT shenzhongxia aberratedmultidimensionaleegcharacteristicsinpatientswithgeneralizedanxietydisorderamachinelearningbasedanalysisframework
AT ligang aberratedmultidimensionaleegcharacteristicsinpatientswithgeneralizedanxietydisorderamachinelearningbasedanalysisframework
AT fangjiaqi aberratedmultidimensionaleegcharacteristicsinpatientswithgeneralizedanxietydisorderamachinelearningbasedanalysisframework
AT zhonghongyang aberratedmultidimensionaleegcharacteristicsinpatientswithgeneralizedanxietydisorderamachinelearningbasedanalysisframework
AT wangjie aberratedmultidimensionaleegcharacteristicsinpatientswithgeneralizedanxietydisorderamachinelearningbasedanalysisframework
AT sunyu aberratedmultidimensionaleegcharacteristicsinpatientswithgeneralizedanxietydisorderamachinelearningbasedanalysisframework
AT shenxinhua aberratedmultidimensionaleegcharacteristicsinpatientswithgeneralizedanxietydisorderamachinelearningbasedanalysisframework