miR449 Protects Airway Regeneration by Controlling AURKA/HDAC6-Mediated Ciliary Disassembly

Airway mucociliary regeneration and function are key players for airway defense and are impaired in chronic obstructive pulmonary disease (COPD). Using transcriptome analysis in COPD-derived bronchial biopsies, we observed a positive correlation between cilia-related genes and microRNA-449 (miR449)....

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Detalles Bibliográficos
Autores principales: Wildung, Merit, Herr, Christian, Riedel, Dietmar, Wiedwald, Cornelia, Moiseenko, Alena, Ramírez, Fidel, Tasena, Hataitip, Heimerl, Maren, Alevra, Mihai, Movsisyan, Naira, Schuldt, Maike, Volceanov-Hahn, Larisa, Provoost, Sharen, Nöthe-Menchen, Tabea, Urrego, Diana, Freytag, Bernard, Wallmeier, Julia, Beisswenger, Christoph, Bals, Robert, van den Berge, Maarten, Timens, Wim, Hiemstra, Pieter S., Brandsma, Corry-Anke, Maes, Tania, Andreas, Stefan, Heijink, Irene H., Pardo, Luis A., Lizé, Muriel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320302/
https://www.ncbi.nlm.nih.gov/pubmed/35887096
http://dx.doi.org/10.3390/ijms23147749

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