Cargando…

The Role of Platelet-Derived Extracellular Vesicles in Immune-Mediated Thrombosis

Platelet-derived extracellular vesicles (PEVs) play important roles in hemostasis and thrombosis. There are three major types of PEVs described based on their size and characteristics, but newer types may continue to emerge owing to the ongoing improvement in the methodologies and terms used to defi...

Descripción completa

Detalles Bibliográficos
Autores principales: Eustes, Alicia S., Dayal, Sanjana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320310/
https://www.ncbi.nlm.nih.gov/pubmed/35887184
http://dx.doi.org/10.3390/ijms23147837
_version_ 1784755761785602048
author Eustes, Alicia S.
Dayal, Sanjana
author_facet Eustes, Alicia S.
Dayal, Sanjana
author_sort Eustes, Alicia S.
collection PubMed
description Platelet-derived extracellular vesicles (PEVs) play important roles in hemostasis and thrombosis. There are three major types of PEVs described based on their size and characteristics, but newer types may continue to emerge owing to the ongoing improvement in the methodologies and terms used to define various types of EVs. As the literature on EVs is growing, there are continuing attempts to standardize protocols for EV isolation and reach consensus in the field. This review provides information on mechanisms of PEV production, characteristics, cellular interaction, and their pathological role, especially in autoimmune and infectious diseases. We also highlight the mechanisms through which PEVs can activate parent cells in a feedback loop.
format Online
Article
Text
id pubmed-9320310
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-93203102022-07-27 The Role of Platelet-Derived Extracellular Vesicles in Immune-Mediated Thrombosis Eustes, Alicia S. Dayal, Sanjana Int J Mol Sci Review Platelet-derived extracellular vesicles (PEVs) play important roles in hemostasis and thrombosis. There are three major types of PEVs described based on their size and characteristics, but newer types may continue to emerge owing to the ongoing improvement in the methodologies and terms used to define various types of EVs. As the literature on EVs is growing, there are continuing attempts to standardize protocols for EV isolation and reach consensus in the field. This review provides information on mechanisms of PEV production, characteristics, cellular interaction, and their pathological role, especially in autoimmune and infectious diseases. We also highlight the mechanisms through which PEVs can activate parent cells in a feedback loop. MDPI 2022-07-16 /pmc/articles/PMC9320310/ /pubmed/35887184 http://dx.doi.org/10.3390/ijms23147837 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Eustes, Alicia S.
Dayal, Sanjana
The Role of Platelet-Derived Extracellular Vesicles in Immune-Mediated Thrombosis
title The Role of Platelet-Derived Extracellular Vesicles in Immune-Mediated Thrombosis
title_full The Role of Platelet-Derived Extracellular Vesicles in Immune-Mediated Thrombosis
title_fullStr The Role of Platelet-Derived Extracellular Vesicles in Immune-Mediated Thrombosis
title_full_unstemmed The Role of Platelet-Derived Extracellular Vesicles in Immune-Mediated Thrombosis
title_short The Role of Platelet-Derived Extracellular Vesicles in Immune-Mediated Thrombosis
title_sort role of platelet-derived extracellular vesicles in immune-mediated thrombosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320310/
https://www.ncbi.nlm.nih.gov/pubmed/35887184
http://dx.doi.org/10.3390/ijms23147837
work_keys_str_mv AT eustesalicias theroleofplateletderivedextracellularvesiclesinimmunemediatedthrombosis
AT dayalsanjana theroleofplateletderivedextracellularvesiclesinimmunemediatedthrombosis
AT eustesalicias roleofplateletderivedextracellularvesiclesinimmunemediatedthrombosis
AT dayalsanjana roleofplateletderivedextracellularvesiclesinimmunemediatedthrombosis