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The Role of Platelet-Derived Extracellular Vesicles in Immune-Mediated Thrombosis
Platelet-derived extracellular vesicles (PEVs) play important roles in hemostasis and thrombosis. There are three major types of PEVs described based on their size and characteristics, but newer types may continue to emerge owing to the ongoing improvement in the methodologies and terms used to defi...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320310/ https://www.ncbi.nlm.nih.gov/pubmed/35887184 http://dx.doi.org/10.3390/ijms23147837 |
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author | Eustes, Alicia S. Dayal, Sanjana |
author_facet | Eustes, Alicia S. Dayal, Sanjana |
author_sort | Eustes, Alicia S. |
collection | PubMed |
description | Platelet-derived extracellular vesicles (PEVs) play important roles in hemostasis and thrombosis. There are three major types of PEVs described based on their size and characteristics, but newer types may continue to emerge owing to the ongoing improvement in the methodologies and terms used to define various types of EVs. As the literature on EVs is growing, there are continuing attempts to standardize protocols for EV isolation and reach consensus in the field. This review provides information on mechanisms of PEV production, characteristics, cellular interaction, and their pathological role, especially in autoimmune and infectious diseases. We also highlight the mechanisms through which PEVs can activate parent cells in a feedback loop. |
format | Online Article Text |
id | pubmed-9320310 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93203102022-07-27 The Role of Platelet-Derived Extracellular Vesicles in Immune-Mediated Thrombosis Eustes, Alicia S. Dayal, Sanjana Int J Mol Sci Review Platelet-derived extracellular vesicles (PEVs) play important roles in hemostasis and thrombosis. There are three major types of PEVs described based on their size and characteristics, but newer types may continue to emerge owing to the ongoing improvement in the methodologies and terms used to define various types of EVs. As the literature on EVs is growing, there are continuing attempts to standardize protocols for EV isolation and reach consensus in the field. This review provides information on mechanisms of PEV production, characteristics, cellular interaction, and their pathological role, especially in autoimmune and infectious diseases. We also highlight the mechanisms through which PEVs can activate parent cells in a feedback loop. MDPI 2022-07-16 /pmc/articles/PMC9320310/ /pubmed/35887184 http://dx.doi.org/10.3390/ijms23147837 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Eustes, Alicia S. Dayal, Sanjana The Role of Platelet-Derived Extracellular Vesicles in Immune-Mediated Thrombosis |
title | The Role of Platelet-Derived Extracellular Vesicles in Immune-Mediated Thrombosis |
title_full | The Role of Platelet-Derived Extracellular Vesicles in Immune-Mediated Thrombosis |
title_fullStr | The Role of Platelet-Derived Extracellular Vesicles in Immune-Mediated Thrombosis |
title_full_unstemmed | The Role of Platelet-Derived Extracellular Vesicles in Immune-Mediated Thrombosis |
title_short | The Role of Platelet-Derived Extracellular Vesicles in Immune-Mediated Thrombosis |
title_sort | role of platelet-derived extracellular vesicles in immune-mediated thrombosis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320310/ https://www.ncbi.nlm.nih.gov/pubmed/35887184 http://dx.doi.org/10.3390/ijms23147837 |
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