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Nucleus Accumbens Response to Reward among Children with a Family History of Alcohol Use Problems: Convergent Findings from the ABCD Study(®) and Michigan Longitudinal Study

Having a family history of alcohol use problems (FH+) conveys risk for alcohol use in offspring. Reward-related brain functioning may play a role in this vulnerability. The present study investigated brain function in the nucleus accumbens (NAcc) associated with the anticipation of reward in youth w...

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Autores principales: Martz, Meghan E., Hardee, Jillian E., Cope, Lora M., McCurry, Katherine L., Soules, Mary, Zucker, Robert A., Heitzeg, Mary M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320357/
https://www.ncbi.nlm.nih.gov/pubmed/35884720
http://dx.doi.org/10.3390/brainsci12070913
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author Martz, Meghan E.
Hardee, Jillian E.
Cope, Lora M.
McCurry, Katherine L.
Soules, Mary
Zucker, Robert A.
Heitzeg, Mary M.
author_facet Martz, Meghan E.
Hardee, Jillian E.
Cope, Lora M.
McCurry, Katherine L.
Soules, Mary
Zucker, Robert A.
Heitzeg, Mary M.
author_sort Martz, Meghan E.
collection PubMed
description Having a family history of alcohol use problems (FH+) conveys risk for alcohol use in offspring. Reward-related brain functioning may play a role in this vulnerability. The present study investigated brain function in the nucleus accumbens (NAcc) associated with the anticipation of reward in youth with two biological parents with alcohol use problems (FH+2), one biological parent with alcohol use problems (FH+1), and no biological parents with alcohol use problems (FH-). Participants were from the large, national Adolescent Brain Cognitive Development (ABCD) Study (mean age: 9.93; 48% female; FH+2 n = 223, FH+1 n = 1447, FH- n = 9690) and the Michigan Longitudinal Study (MLS), consisting of community-recruited families with high rates of alcohol use disorder (mean age: 10.54; 39.3% female; FH+2 n = 40, FH+1 n = 51, FH- n = 40). Reward anticipation was measured by the monetary incentive delay task. Regression models were used to assess associations between FH status and the anticipation of large rewards in right and left NAcc regions of interest. In both studies, FH+2 youth showed blunted anticipatory reward responding in the right NAcc compared to FH+1 youth. In the MLS, FH+2 youth also had blunted anticipatory reward responding in the right NAcc compared to the FH- group. Convergent results across two separate samples provide insights into a unique vulnerability of FH+2 youth and suggest that binary FH+ versus FH- categorizations may obscure important differences within FH+ youth.
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spelling pubmed-93203572022-07-27 Nucleus Accumbens Response to Reward among Children with a Family History of Alcohol Use Problems: Convergent Findings from the ABCD Study(®) and Michigan Longitudinal Study Martz, Meghan E. Hardee, Jillian E. Cope, Lora M. McCurry, Katherine L. Soules, Mary Zucker, Robert A. Heitzeg, Mary M. Brain Sci Brief Report Having a family history of alcohol use problems (FH+) conveys risk for alcohol use in offspring. Reward-related brain functioning may play a role in this vulnerability. The present study investigated brain function in the nucleus accumbens (NAcc) associated with the anticipation of reward in youth with two biological parents with alcohol use problems (FH+2), one biological parent with alcohol use problems (FH+1), and no biological parents with alcohol use problems (FH-). Participants were from the large, national Adolescent Brain Cognitive Development (ABCD) Study (mean age: 9.93; 48% female; FH+2 n = 223, FH+1 n = 1447, FH- n = 9690) and the Michigan Longitudinal Study (MLS), consisting of community-recruited families with high rates of alcohol use disorder (mean age: 10.54; 39.3% female; FH+2 n = 40, FH+1 n = 51, FH- n = 40). Reward anticipation was measured by the monetary incentive delay task. Regression models were used to assess associations between FH status and the anticipation of large rewards in right and left NAcc regions of interest. In both studies, FH+2 youth showed blunted anticipatory reward responding in the right NAcc compared to FH+1 youth. In the MLS, FH+2 youth also had blunted anticipatory reward responding in the right NAcc compared to the FH- group. Convergent results across two separate samples provide insights into a unique vulnerability of FH+2 youth and suggest that binary FH+ versus FH- categorizations may obscure important differences within FH+ youth. MDPI 2022-07-13 /pmc/articles/PMC9320357/ /pubmed/35884720 http://dx.doi.org/10.3390/brainsci12070913 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Martz, Meghan E.
Hardee, Jillian E.
Cope, Lora M.
McCurry, Katherine L.
Soules, Mary
Zucker, Robert A.
Heitzeg, Mary M.
Nucleus Accumbens Response to Reward among Children with a Family History of Alcohol Use Problems: Convergent Findings from the ABCD Study(®) and Michigan Longitudinal Study
title Nucleus Accumbens Response to Reward among Children with a Family History of Alcohol Use Problems: Convergent Findings from the ABCD Study(®) and Michigan Longitudinal Study
title_full Nucleus Accumbens Response to Reward among Children with a Family History of Alcohol Use Problems: Convergent Findings from the ABCD Study(®) and Michigan Longitudinal Study
title_fullStr Nucleus Accumbens Response to Reward among Children with a Family History of Alcohol Use Problems: Convergent Findings from the ABCD Study(®) and Michigan Longitudinal Study
title_full_unstemmed Nucleus Accumbens Response to Reward among Children with a Family History of Alcohol Use Problems: Convergent Findings from the ABCD Study(®) and Michigan Longitudinal Study
title_short Nucleus Accumbens Response to Reward among Children with a Family History of Alcohol Use Problems: Convergent Findings from the ABCD Study(®) and Michigan Longitudinal Study
title_sort nucleus accumbens response to reward among children with a family history of alcohol use problems: convergent findings from the abcd study(®) and michigan longitudinal study
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320357/
https://www.ncbi.nlm.nih.gov/pubmed/35884720
http://dx.doi.org/10.3390/brainsci12070913
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