The Mesenchymal Niche in Myelodysplastic Syndromes

Myelodysplastic syndromes (MDSs) are clonal disorders characterized by ineffective hematopoiesis, resulting in cytopenias and a risk of developing acute myeloid leukemia. In addition to mutations affecting hematopoietic stem cells (HSCs), numerous studies have highlighted the role of the bone marrow...

Descripción completa

Detalles Bibliográficos
Autores principales: Friedrich, Chloé, Kosmider, Olivier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320414/
https://www.ncbi.nlm.nih.gov/pubmed/35885544
http://dx.doi.org/10.3390/diagnostics12071639
_version_ 1784755786731225088
author Friedrich, Chloé
Kosmider, Olivier
author_facet Friedrich, Chloé
Kosmider, Olivier
author_sort Friedrich, Chloé
collection PubMed
description Myelodysplastic syndromes (MDSs) are clonal disorders characterized by ineffective hematopoiesis, resulting in cytopenias and a risk of developing acute myeloid leukemia. In addition to mutations affecting hematopoietic stem cells (HSCs), numerous studies have highlighted the role of the bone marrow microenvironment (BMME) in the development of MDSs. The mesenchymal niche represents a key component of the BMME. In this review, we discuss the role of the mesenchymal niche in the pathophysiology of MDS and provide an overview of currently available in vitro and in vivo models that can be used to study the effects of the mesenchymal niche on HSCs.
format Online
Article
Text
id pubmed-9320414
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-93204142022-07-27 The Mesenchymal Niche in Myelodysplastic Syndromes Friedrich, Chloé Kosmider, Olivier Diagnostics (Basel) Review Myelodysplastic syndromes (MDSs) are clonal disorders characterized by ineffective hematopoiesis, resulting in cytopenias and a risk of developing acute myeloid leukemia. In addition to mutations affecting hematopoietic stem cells (HSCs), numerous studies have highlighted the role of the bone marrow microenvironment (BMME) in the development of MDSs. The mesenchymal niche represents a key component of the BMME. In this review, we discuss the role of the mesenchymal niche in the pathophysiology of MDS and provide an overview of currently available in vitro and in vivo models that can be used to study the effects of the mesenchymal niche on HSCs. MDPI 2022-07-05 /pmc/articles/PMC9320414/ /pubmed/35885544 http://dx.doi.org/10.3390/diagnostics12071639 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Friedrich, Chloé
Kosmider, Olivier
The Mesenchymal Niche in Myelodysplastic Syndromes
title The Mesenchymal Niche in Myelodysplastic Syndromes
title_full The Mesenchymal Niche in Myelodysplastic Syndromes
title_fullStr The Mesenchymal Niche in Myelodysplastic Syndromes
title_full_unstemmed The Mesenchymal Niche in Myelodysplastic Syndromes
title_short The Mesenchymal Niche in Myelodysplastic Syndromes
title_sort mesenchymal niche in myelodysplastic syndromes
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320414/
https://www.ncbi.nlm.nih.gov/pubmed/35885544
http://dx.doi.org/10.3390/diagnostics12071639
work_keys_str_mv AT friedrichchloe themesenchymalnicheinmyelodysplasticsyndromes
AT kosmiderolivier themesenchymalnicheinmyelodysplasticsyndromes
AT friedrichchloe mesenchymalnicheinmyelodysplasticsyndromes
AT kosmiderolivier mesenchymalnicheinmyelodysplasticsyndromes

Ejemplares similares