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Evaluation of the Structural Modification of Ibuprofen on the Penetration Release of Ibuprofen from a Drug-in-Adhesive Matrix Type Transdermal Patch
This study aimed to evaluate the effect of chemical modifications of the structure of active compounds on the skin permeation and accumulation of ibuprofen [IBU] from the acrylic pressure-sensitive adhesive used as a drug-in-adhesives matrix type transdermal patch. The active substances tested were...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320482/ https://www.ncbi.nlm.nih.gov/pubmed/35887099 http://dx.doi.org/10.3390/ijms23147752 |
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author | Ossowicz-Rupniewska, Paula Bednarczyk, Paulina Nowak, Małgorzata Nowak, Anna Duchnik, Wiktoria Kucharski, Łukasz Klebeko, Joanna Świątek, Ewelina Bilska, Karolina Rokicka, Joanna Janus, Ewa Klimowicz, Adam Czech, Zbigniew |
author_facet | Ossowicz-Rupniewska, Paula Bednarczyk, Paulina Nowak, Małgorzata Nowak, Anna Duchnik, Wiktoria Kucharski, Łukasz Klebeko, Joanna Świątek, Ewelina Bilska, Karolina Rokicka, Joanna Janus, Ewa Klimowicz, Adam Czech, Zbigniew |
author_sort | Ossowicz-Rupniewska, Paula |
collection | PubMed |
description | This study aimed to evaluate the effect of chemical modifications of the structure of active compounds on the skin permeation and accumulation of ibuprofen [IBU] from the acrylic pressure-sensitive adhesive used as a drug-in-adhesives matrix type transdermal patch. The active substances tested were ibuprofen salts obtained by pairing the ibuprofen anion with organic cations, such as amino acid isopropyl esters. The structural modification of ibuprofen tested were Ibuprofen sodium salt, [GlyOiPr][IBU], [AlaOiPr][IBU], [ValOiPr][IBU], [SerOiPr][IBU], [ThrOiPr][IBU], [(AspOiPr)(2)][IBU], [LysOiPr][IBU], [LysOiPr][IBU](2), [PheOiPr][IBU], and [ProOiPr][IBU]. For comparison, the penetration of unmodified ibuprofen and commercially available patches was also investigated. Thus, twelve transdermal patches with new drug modifications have been developed whose adhesive carrier is an acrylate copolymer. The obtained patches were characterized for their adhesive properties and tested for permeability of the active substance. Our results show that the obtained ibuprofen patches demonstrate similar permeability to commercial patches compared to those with structural modifications of ibuprofen. However, these modified patches show an increased drug permeability of 2.3 to even 6.4 times greater than unmodified ibuprofen. Increasing the permeability of the active substance and properties such as adhesion, cohesion, and tack make the obtained patches an excellent alternative to commercial patches containing ibuprofen. |
format | Online Article Text |
id | pubmed-9320482 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93204822022-07-27 Evaluation of the Structural Modification of Ibuprofen on the Penetration Release of Ibuprofen from a Drug-in-Adhesive Matrix Type Transdermal Patch Ossowicz-Rupniewska, Paula Bednarczyk, Paulina Nowak, Małgorzata Nowak, Anna Duchnik, Wiktoria Kucharski, Łukasz Klebeko, Joanna Świątek, Ewelina Bilska, Karolina Rokicka, Joanna Janus, Ewa Klimowicz, Adam Czech, Zbigniew Int J Mol Sci Article This study aimed to evaluate the effect of chemical modifications of the structure of active compounds on the skin permeation and accumulation of ibuprofen [IBU] from the acrylic pressure-sensitive adhesive used as a drug-in-adhesives matrix type transdermal patch. The active substances tested were ibuprofen salts obtained by pairing the ibuprofen anion with organic cations, such as amino acid isopropyl esters. The structural modification of ibuprofen tested were Ibuprofen sodium salt, [GlyOiPr][IBU], [AlaOiPr][IBU], [ValOiPr][IBU], [SerOiPr][IBU], [ThrOiPr][IBU], [(AspOiPr)(2)][IBU], [LysOiPr][IBU], [LysOiPr][IBU](2), [PheOiPr][IBU], and [ProOiPr][IBU]. For comparison, the penetration of unmodified ibuprofen and commercially available patches was also investigated. Thus, twelve transdermal patches with new drug modifications have been developed whose adhesive carrier is an acrylate copolymer. The obtained patches were characterized for their adhesive properties and tested for permeability of the active substance. Our results show that the obtained ibuprofen patches demonstrate similar permeability to commercial patches compared to those with structural modifications of ibuprofen. However, these modified patches show an increased drug permeability of 2.3 to even 6.4 times greater than unmodified ibuprofen. Increasing the permeability of the active substance and properties such as adhesion, cohesion, and tack make the obtained patches an excellent alternative to commercial patches containing ibuprofen. MDPI 2022-07-13 /pmc/articles/PMC9320482/ /pubmed/35887099 http://dx.doi.org/10.3390/ijms23147752 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Ossowicz-Rupniewska, Paula Bednarczyk, Paulina Nowak, Małgorzata Nowak, Anna Duchnik, Wiktoria Kucharski, Łukasz Klebeko, Joanna Świątek, Ewelina Bilska, Karolina Rokicka, Joanna Janus, Ewa Klimowicz, Adam Czech, Zbigniew Evaluation of the Structural Modification of Ibuprofen on the Penetration Release of Ibuprofen from a Drug-in-Adhesive Matrix Type Transdermal Patch |
title | Evaluation of the Structural Modification of Ibuprofen on the Penetration Release of Ibuprofen from a Drug-in-Adhesive Matrix Type Transdermal Patch |
title_full | Evaluation of the Structural Modification of Ibuprofen on the Penetration Release of Ibuprofen from a Drug-in-Adhesive Matrix Type Transdermal Patch |
title_fullStr | Evaluation of the Structural Modification of Ibuprofen on the Penetration Release of Ibuprofen from a Drug-in-Adhesive Matrix Type Transdermal Patch |
title_full_unstemmed | Evaluation of the Structural Modification of Ibuprofen on the Penetration Release of Ibuprofen from a Drug-in-Adhesive Matrix Type Transdermal Patch |
title_short | Evaluation of the Structural Modification of Ibuprofen on the Penetration Release of Ibuprofen from a Drug-in-Adhesive Matrix Type Transdermal Patch |
title_sort | evaluation of the structural modification of ibuprofen on the penetration release of ibuprofen from a drug-in-adhesive matrix type transdermal patch |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320482/ https://www.ncbi.nlm.nih.gov/pubmed/35887099 http://dx.doi.org/10.3390/ijms23147752 |
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