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Reconnoitering the Therapeutic Role of Curcumin in Disease Prevention and Treatment: Lessons Learnt and Future Directions
Turmeric is a plant with a very long history of medicinal use across different cultures. Curcumin is the active part of turmeric, which has exhibited various beneficial physiological and pharmacological effects. This review aims to critically appraise the corpus of literature associated with the abo...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320502/ https://www.ncbi.nlm.nih.gov/pubmed/35888763 http://dx.doi.org/10.3390/metabo12070639 |
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author | Sivani, Bala Mohan Azzeh, Mahmoud Patnaik, Rajashree Pantea Stoian, Anca Rizzo, Manfredi Banerjee, Yajnavalka |
author_facet | Sivani, Bala Mohan Azzeh, Mahmoud Patnaik, Rajashree Pantea Stoian, Anca Rizzo, Manfredi Banerjee, Yajnavalka |
author_sort | Sivani, Bala Mohan |
collection | PubMed |
description | Turmeric is a plant with a very long history of medicinal use across different cultures. Curcumin is the active part of turmeric, which has exhibited various beneficial physiological and pharmacological effects. This review aims to critically appraise the corpus of literature associated with the above pharmacological properties of curcumin, with a specific focus on antioxidant, anti-inflammatory, anticancer and antimicrobial properties. We have also reviewed the different extraction strategies currently in practice, highlighting the strengths and drawbacks of each technique. Further, our review also summarizes the clinical trials that have been conducted with curcumin, which will allow the reader to get a quick insight into the disease/patient population of interest with the outcome that was investigated. Lastly, we have also highlighted the research areas that need to be further scrutinized to better grasp curcumin’s beneficial physiological and medicinal properties, which can then be translated to facilitate the design of better bioactive therapeutic leads. |
format | Online Article Text |
id | pubmed-9320502 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-93205022022-07-27 Reconnoitering the Therapeutic Role of Curcumin in Disease Prevention and Treatment: Lessons Learnt and Future Directions Sivani, Bala Mohan Azzeh, Mahmoud Patnaik, Rajashree Pantea Stoian, Anca Rizzo, Manfredi Banerjee, Yajnavalka Metabolites Review Turmeric is a plant with a very long history of medicinal use across different cultures. Curcumin is the active part of turmeric, which has exhibited various beneficial physiological and pharmacological effects. This review aims to critically appraise the corpus of literature associated with the above pharmacological properties of curcumin, with a specific focus on antioxidant, anti-inflammatory, anticancer and antimicrobial properties. We have also reviewed the different extraction strategies currently in practice, highlighting the strengths and drawbacks of each technique. Further, our review also summarizes the clinical trials that have been conducted with curcumin, which will allow the reader to get a quick insight into the disease/patient population of interest with the outcome that was investigated. Lastly, we have also highlighted the research areas that need to be further scrutinized to better grasp curcumin’s beneficial physiological and medicinal properties, which can then be translated to facilitate the design of better bioactive therapeutic leads. MDPI 2022-07-12 /pmc/articles/PMC9320502/ /pubmed/35888763 http://dx.doi.org/10.3390/metabo12070639 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Sivani, Bala Mohan Azzeh, Mahmoud Patnaik, Rajashree Pantea Stoian, Anca Rizzo, Manfredi Banerjee, Yajnavalka Reconnoitering the Therapeutic Role of Curcumin in Disease Prevention and Treatment: Lessons Learnt and Future Directions |
title | Reconnoitering the Therapeutic Role of Curcumin in Disease Prevention and Treatment: Lessons Learnt and Future Directions |
title_full | Reconnoitering the Therapeutic Role of Curcumin in Disease Prevention and Treatment: Lessons Learnt and Future Directions |
title_fullStr | Reconnoitering the Therapeutic Role of Curcumin in Disease Prevention and Treatment: Lessons Learnt and Future Directions |
title_full_unstemmed | Reconnoitering the Therapeutic Role of Curcumin in Disease Prevention and Treatment: Lessons Learnt and Future Directions |
title_short | Reconnoitering the Therapeutic Role of Curcumin in Disease Prevention and Treatment: Lessons Learnt and Future Directions |
title_sort | reconnoitering the therapeutic role of curcumin in disease prevention and treatment: lessons learnt and future directions |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320502/ https://www.ncbi.nlm.nih.gov/pubmed/35888763 http://dx.doi.org/10.3390/metabo12070639 |
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