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Virus Infections Play Crucial Roles in the Pathogenesis of Sjögren’s Syndrome

Sjögren’s syndrome (SS) is an autoimmune disease especially targeting exocrine glands, such as the salivary and lacrimal glands. A radical therapy for SS based on its etiology has not been established because of the complex pathogenesis of the disease. Several studies have demonstrated a relationshi...

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Autores principales: Otsuka, Kunihiro, Sato, Mami, Tsunematsu, Takaaki, Ishimaru, Naozumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320594/
https://www.ncbi.nlm.nih.gov/pubmed/35891453
http://dx.doi.org/10.3390/v14071474
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author Otsuka, Kunihiro
Sato, Mami
Tsunematsu, Takaaki
Ishimaru, Naozumi
author_facet Otsuka, Kunihiro
Sato, Mami
Tsunematsu, Takaaki
Ishimaru, Naozumi
author_sort Otsuka, Kunihiro
collection PubMed
description Sjögren’s syndrome (SS) is an autoimmune disease especially targeting exocrine glands, such as the salivary and lacrimal glands. A radical therapy for SS based on its etiology has not been established because of the complex pathogenesis of the disease. Several studies have demonstrated a relationship between virus infection and SS pathogenesis. In particular, infection with the Epstein-Barr (EB) virus among others is a potent factor associated with the onset or development of SS. Specifically, virus infection in the target organs of SS triggers or promotes autoreactive responses involving the process of autoantigen formation, antigen-presenting function, or T-cell response. Our review of recent research highlights the crucial roles of virus infection in the pathogenesis of SS and discusses the critical association between virus infection and the etiology of autoimmunity in SS.
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spelling pubmed-93205942022-07-27 Virus Infections Play Crucial Roles in the Pathogenesis of Sjögren’s Syndrome Otsuka, Kunihiro Sato, Mami Tsunematsu, Takaaki Ishimaru, Naozumi Viruses Review Sjögren’s syndrome (SS) is an autoimmune disease especially targeting exocrine glands, such as the salivary and lacrimal glands. A radical therapy for SS based on its etiology has not been established because of the complex pathogenesis of the disease. Several studies have demonstrated a relationship between virus infection and SS pathogenesis. In particular, infection with the Epstein-Barr (EB) virus among others is a potent factor associated with the onset or development of SS. Specifically, virus infection in the target organs of SS triggers or promotes autoreactive responses involving the process of autoantigen formation, antigen-presenting function, or T-cell response. Our review of recent research highlights the crucial roles of virus infection in the pathogenesis of SS and discusses the critical association between virus infection and the etiology of autoimmunity in SS. MDPI 2022-07-04 /pmc/articles/PMC9320594/ /pubmed/35891453 http://dx.doi.org/10.3390/v14071474 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Otsuka, Kunihiro
Sato, Mami
Tsunematsu, Takaaki
Ishimaru, Naozumi
Virus Infections Play Crucial Roles in the Pathogenesis of Sjögren’s Syndrome
title Virus Infections Play Crucial Roles in the Pathogenesis of Sjögren’s Syndrome
title_full Virus Infections Play Crucial Roles in the Pathogenesis of Sjögren’s Syndrome
title_fullStr Virus Infections Play Crucial Roles in the Pathogenesis of Sjögren’s Syndrome
title_full_unstemmed Virus Infections Play Crucial Roles in the Pathogenesis of Sjögren’s Syndrome
title_short Virus Infections Play Crucial Roles in the Pathogenesis of Sjögren’s Syndrome
title_sort virus infections play crucial roles in the pathogenesis of sjögren’s syndrome
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320594/
https://www.ncbi.nlm.nih.gov/pubmed/35891453
http://dx.doi.org/10.3390/v14071474
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