Cargando…

Reactogenicity of mRNA- and Non-mRNA-Based COVID-19 Vaccines among Lactating Mother and Child Dyads

The aims of the study are to: (a) Describe the reactogenicity of WHO-approved two mRNA (Pfizer-BioNTech, Moderna) and two non-RNA (Oxford-AstraZeneca, Sinovac) vaccines among lactating mother and child pairs, and (b) Compare and contrast the reactogenicity between mRNA and non-mRNA vaccines. A cross...

Descripción completa

Detalles Bibliográficos
Autores principales: Jacob-Chow, Beth, Vasundhara, Kandarpa Lakshmi, Cheang, Hon Kit, Lee, Le Ye, Low, Jia Ming, Amin, Zubair
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320631/
https://www.ncbi.nlm.nih.gov/pubmed/35891258
http://dx.doi.org/10.3390/vaccines10071094
_version_ 1784755839017418752
author Jacob-Chow, Beth
Vasundhara, Kandarpa Lakshmi
Cheang, Hon Kit
Lee, Le Ye
Low, Jia Ming
Amin, Zubair
author_facet Jacob-Chow, Beth
Vasundhara, Kandarpa Lakshmi
Cheang, Hon Kit
Lee, Le Ye
Low, Jia Ming
Amin, Zubair
author_sort Jacob-Chow, Beth
collection PubMed
description The aims of the study are to: (a) Describe the reactogenicity of WHO-approved two mRNA (Pfizer-BioNTech, Moderna) and two non-RNA (Oxford-AstraZeneca, Sinovac) vaccines among lactating mother and child pairs, and (b) Compare and contrast the reactogenicity between mRNA and non-mRNA vaccines. A cross-sectional, self-reported survey was conducted amongst 1784 lactating women who received COVID-19 vaccinations. The most common maternal adverse reaction was a local reaction at the injection site, and the largest minority of respondents, 49.6% (780/1571), reported experiencing worse symptoms when receiving the second dose compared to the first dose. Respondents reported no major adverse effects or behavioural changes in the breastfed children for the duration of the study period. Among respondents who received non-mRNA COVID-19 vaccines, a majority reported no change in lactation, but those who did more commonly reported changes in the quantity of milk supply and pain in the breast. The more commonly reported lactation changes (fluctuations in breast milk supply quantity and pain in the breast) for the non-mRNA vaccines were similar to those of respondents who received mRNA vaccines. Our study, with a large, racially diverse cohort, further augments earlier reported findings in that the COVID-19 vaccines tested in this study did not cause any serious adverse events in our population for the duration of our survey period, although long-term effects are yet to be studied.
format Online
Article
Text
id pubmed-9320631
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-93206312022-07-27 Reactogenicity of mRNA- and Non-mRNA-Based COVID-19 Vaccines among Lactating Mother and Child Dyads Jacob-Chow, Beth Vasundhara, Kandarpa Lakshmi Cheang, Hon Kit Lee, Le Ye Low, Jia Ming Amin, Zubair Vaccines (Basel) Article The aims of the study are to: (a) Describe the reactogenicity of WHO-approved two mRNA (Pfizer-BioNTech, Moderna) and two non-RNA (Oxford-AstraZeneca, Sinovac) vaccines among lactating mother and child pairs, and (b) Compare and contrast the reactogenicity between mRNA and non-mRNA vaccines. A cross-sectional, self-reported survey was conducted amongst 1784 lactating women who received COVID-19 vaccinations. The most common maternal adverse reaction was a local reaction at the injection site, and the largest minority of respondents, 49.6% (780/1571), reported experiencing worse symptoms when receiving the second dose compared to the first dose. Respondents reported no major adverse effects or behavioural changes in the breastfed children for the duration of the study period. Among respondents who received non-mRNA COVID-19 vaccines, a majority reported no change in lactation, but those who did more commonly reported changes in the quantity of milk supply and pain in the breast. The more commonly reported lactation changes (fluctuations in breast milk supply quantity and pain in the breast) for the non-mRNA vaccines were similar to those of respondents who received mRNA vaccines. Our study, with a large, racially diverse cohort, further augments earlier reported findings in that the COVID-19 vaccines tested in this study did not cause any serious adverse events in our population for the duration of our survey period, although long-term effects are yet to be studied. MDPI 2022-07-08 /pmc/articles/PMC9320631/ /pubmed/35891258 http://dx.doi.org/10.3390/vaccines10071094 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jacob-Chow, Beth
Vasundhara, Kandarpa Lakshmi
Cheang, Hon Kit
Lee, Le Ye
Low, Jia Ming
Amin, Zubair
Reactogenicity of mRNA- and Non-mRNA-Based COVID-19 Vaccines among Lactating Mother and Child Dyads
title Reactogenicity of mRNA- and Non-mRNA-Based COVID-19 Vaccines among Lactating Mother and Child Dyads
title_full Reactogenicity of mRNA- and Non-mRNA-Based COVID-19 Vaccines among Lactating Mother and Child Dyads
title_fullStr Reactogenicity of mRNA- and Non-mRNA-Based COVID-19 Vaccines among Lactating Mother and Child Dyads
title_full_unstemmed Reactogenicity of mRNA- and Non-mRNA-Based COVID-19 Vaccines among Lactating Mother and Child Dyads
title_short Reactogenicity of mRNA- and Non-mRNA-Based COVID-19 Vaccines among Lactating Mother and Child Dyads
title_sort reactogenicity of mrna- and non-mrna-based covid-19 vaccines among lactating mother and child dyads
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320631/
https://www.ncbi.nlm.nih.gov/pubmed/35891258
http://dx.doi.org/10.3390/vaccines10071094
work_keys_str_mv AT jacobchowbeth reactogenicityofmrnaandnonmrnabasedcovid19vaccinesamonglactatingmotherandchilddyads
AT vasundharakandarpalakshmi reactogenicityofmrnaandnonmrnabasedcovid19vaccinesamonglactatingmotherandchilddyads
AT cheanghonkit reactogenicityofmrnaandnonmrnabasedcovid19vaccinesamonglactatingmotherandchilddyads
AT leeleye reactogenicityofmrnaandnonmrnabasedcovid19vaccinesamonglactatingmotherandchilddyads
AT lowjiaming reactogenicityofmrnaandnonmrnabasedcovid19vaccinesamonglactatingmotherandchilddyads
AT aminzubair reactogenicityofmrnaandnonmrnabasedcovid19vaccinesamonglactatingmotherandchilddyads