Inhibition of DNA Repair by Inappropriate Activation of ATM, PARP, and DNA-PK with the Drug Agonist AsiDNA

AsiDNA is a DNA repair inhibitor mimicking DNA double-strand breaks (DSB) that was designed to disorganize DSB repair pathways to sensitize tumors to DNA damaging therapies such as radiotherapy and chemotherapy. We used the property of AsiDNA of triggering artificial DNA damage signaling to examine...

Descripción completa

Detalles Bibliográficos
Autores principales: Berthault, Nathalie, Bergam, Ptissam, Pereira, Floriane, Girard, Pierre-Marie, Dutreix, Marie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320633/
https://www.ncbi.nlm.nih.gov/pubmed/35883597
http://dx.doi.org/10.3390/cells11142149

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320633/
https://www.ncbi.nlm.nih.gov/pubmed/35883597
http://dx.doi.org/10.3390/cells11142149

Ejemplares similares