Cargando…

Inhibition of DNA Repair by Inappropriate Activation of ATM, PARP, and DNA-PK with the Drug Agonist AsiDNA

AsiDNA is a DNA repair inhibitor mimicking DNA double-strand breaks (DSB) that was designed to disorganize DSB repair pathways to sensitize tumors to DNA damaging therapies such as radiotherapy and chemotherapy. We used the property of AsiDNA of triggering artificial DNA damage signaling to examine...

Descripción completa

Detalles Bibliográficos
Autores principales:	Berthault, Nathalie, Bergam, Ptissam, Pereira, Floriane, Girard, Pierre-Marie, Dutreix, Marie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320633/ https://www.ncbi.nlm.nih.gov/pubmed/35883597 http://dx.doi.org/10.3390/cells11142149

Ejemplares similares

Preclinical Studies Comparing Efficacy and Toxicity of DNA Repair Inhibitors, Olaparib, and AsiDNA, in the Treatment of Carboplatin-Resistant Tumors
por: Herath, Nirmitha I., et al.
Publicado: (2019)

Evolution of tumor cells during AsiDNA treatment results in energy exhaustion, decrease in responsiveness to signal, and higher sensitivity to the drug
por: Girard, Pierre‐Marie, et al.
Publicado: (2020)

AsiDNA Treatment Induces Cumulative Antitumor Efficacy with a Low Probability of Acquired Resistance()()
por: Jdey, Wael, et al.
Publicado: (2019)

Effect of DNA repair inhibitor AsiDNA on the incidence of telomere fusion in crisis
por: Subecz, Chloé, et al.
Publicado: (2021)

Inhibition of DNA damage repair by artificial activation of PARP with siDNA
por: Croset, Amelie, et al.
Publicado: (2013)

Hyperactivation of DNA-PK by Double-Strand Break Mimicking Molecules Disorganizes DNA Damage Response
por: Quanz, Maria, et al.
Publicado: (2009)

DNA-PK Target Identification Reveals Novel Links between DNA Repair Signaling and Cytoskeletal Regulation
por: Kotula, Ewa, et al.
Publicado: (2013)

A Phase 1 dose-escalation study to evaluate safety, pharmacokinetics and pharmacodynamics of AsiDNA, a first-in-class DNA repair inhibitor, administered intravenously in patients with advanced solid tumours
por: Le Tourneau, Christophe, et al.
Publicado: (2020)

Both ATM and DNA-PK Are the Main Regulators of HIV-1 Post-Integrational DNA Repair
por: Anisenko, Andrey, et al.
Publicado: (2023)

Visualization of a DNA-PK/PARP1 complex
por: Spagnolo, Laura, et al.
Publicado: (2012)

DNA damage-induced inhibition of rRNA synthesis by DNA-PK and PARP-1
por: Calkins, Anne S., et al.
Publicado: (2013)

DNA-PK, ATM and ATR collaboratively regulate p53-RPA interaction to facilitate homologous recombination DNA repair
por: Serrano, Moises A., et al.
Publicado: (2012)

Interaction between ATM and PARP-1 in response to DNA damage and sensitization of ATM deficient cells through PARP inhibition
por: Aguilar-Quesada, Rocío, et al.
Publicado: (2007)

Combining the DNA Repair Inhibitor Dbait With Radiotherapy for the Treatment of High Grade Glioma: Efficacy and Protein Biomarkers of Resistance in Preclinical Models
por: Biau, Julian, et al.
Publicado: (2019)

PARP Inhibitor Olaparib Causes No Potentiation of the Bleomycin Effect in VERO Cells, Even in the Presence of Pooled ATM, DNA-PK, and LigIV Inhibitors
por: Perini, Valentina, et al.
Publicado: (2020)

Clustered DNA damage induces pan-nuclear H2AX phosphorylation mediated by ATM and DNA–PK
por: Meyer, Barbara, et al.
Publicado: (2013)

The PARP3- and ATM-dependent phosphorylation of APLF facilitates DNA double-strand break repair
por: Fenton, Amanda L., et al.
Publicado: (2013)

Beyond the Trinity of ATM, ATR, and DNA-PK: Multiple Kinases Shape the DNA Damage Response in Concert With RNA Metabolism
por: Burger, Kaspar, et al.
Publicado: (2019)

Ionizing radiation-induced XRCC4 phosphorylation is mediated through ATM in addition to DNA-PK
por: IMAMICHI, Shoji, et al.
Publicado: (2014)

Sensitizing Ewing sarcoma to chemo- and radiotherapy by inhibition of the DNA-repair enzymes DNA protein kinase (DNA-PK) and poly-ADP-ribose polymerase (PARP) 1/2
por: Vormoor, Britta, et al.
Publicado: (2017)

Inhibition of DNA-PK activity sensitizes A549 cells to X-ray irradiation by inducing the ATM-dependent DNA damage response
por: Yang, Lina, et al.
Publicado: (2018)

Distinct roles for DNA-PK, ATM and ATR in RPA phosphorylation and checkpoint activation in response to replication stress
por: Liu, Shengqin, et al.
Publicado: (2012)

Small Molecules, Inhibitors of DNA-PK, Targeting DNA Repair, and Beyond
por: Davidson, David, et al.
Publicado: (2013)

High Fidelity Deep Sequencing Reveals No Effect of ATM, ATR, and DNA-PK Cellular DNA Damage Response Pathways on Adenovirus Mutation Rate
por: Risso-Ballester, Jennifer, et al.
Publicado: (2019)

Live-cell tracking of γ-H2AX kinetics reveals the distinct modes of ATM and DNA-PK in the immediate response to DNA damage
por: Trakarnphornsombat, Watanya, et al.
Publicado: (2023)

ATM phosphorylates the FATC domain of DNA-PK(cs) at threonine 4102 to promote non-homologous end joining
por: Lu, Huiming, et al.
Publicado: (2023)

Comparison of distribution and activity of nanoparticles with short interfering DNA (Dbait) in various living systems
por: Berthault, N, et al.
Publicado: (2011)

CC-115, a dual inhibitor of mTOR kinase and DNA-PK, blocks DNA damage repair pathways and selectively inhibits ATM-deficient cell growth in vitro
por: Tsuji, Toshiya, et al.
Publicado: (2017)

Targeting DNA Repair and Chromatin Crosstalk in Cancer Therapy
por: Johnson, Danielle P., et al.
Publicado: (2021)

Clinical PARP inhibitors allosterically induce PARP2 retention on DNA
por: Langelier, Marie-France, et al.
Publicado: (2023)

PARP1 recruits DNA translocases to restrain DNA replication and facilitate DNA repair
por: Ho, Yen-Chih, et al.
Publicado: (2022)

Deficiency of the DNA repair enzyme ATM in rheumatoid arthritis
por: Shao, Lan, et al.
Publicado: (2009)

ATM’s Role in the Repair of DNA Double-Strand Breaks
por: Shibata, Atsushi, et al.
Publicado: (2021)

Altering DNA Repair to Improve Radiation Therapy: Specific and Multiple Pathway Targeting
por: Biau, Julian, et al.
Publicado: (2019)

DNA-PKcs PARylation regulates DNA-PK kinase activity in the DNA damage response
por: Han, Yang, et al.
Publicado: (2019)

Combining PARP and DNA-PK Inhibitors With Irradiation Inhibits HPV-Negative Head and Neck Cancer Squamous Carcinoma Growth
por: Zeng, Ling, et al.
Publicado: (2020)

Resistance to DNA-damaging treatment in non-small cell lung cancer tumor-initiating cells involves reduced DNA-PK/ATM activation and diminished cell cycle arrest
por: Lundholm, L, et al.
Publicado: (2013)

AIF-mediated caspase-independent necroptosis requires ATM and DNA-PK-induced histone H2AX Ser139 phosphorylation
por: Baritaud, M, et al.
Publicado: (2012)

Impact of ATM and DNA-PK Inhibition on Gene Expression and Individual Response of Human Lymphocytes to Mixed Beams of Alpha Particles and X-Rays
por: Cheng, Lei, et al.
Publicado: (2019)

The role of PARP in DNA repair and its therapeutic exploitation
por: Javle, M, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_95je22tori7757marokk2107od