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Association of TNF–α rs1800629 with Adult Acute B-Cell Lymphoblastic Leukemia

TNF–α influences lymphomagenesis by upregulating proinflammatory and antiapoptotic pathways. In this study, we evaluated the frequency of TNF–α rs1800629 (–308 G>A) polymorphism in newly diagnosed adult patients with acute lymphoblastic leukemia (ALL) and its correlation with age at diagnosis, ge...

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Autores principales: Abdalhabib, Ezeldine K., Algarni, Abdulrahman, Saboor, Muhammad, Alanazi, Fehaid, Ibrahim, Ibrahim K., Alfeel, Ayman H., Alanazi, Abdullah M., Alanazi, Abdulmajeed M., Alruwaili, Abdulaziz M., Alanazi, Muath H., Alshaikh, Nahla A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320751/
https://www.ncbi.nlm.nih.gov/pubmed/35886021
http://dx.doi.org/10.3390/genes13071237
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author Abdalhabib, Ezeldine K.
Algarni, Abdulrahman
Saboor, Muhammad
Alanazi, Fehaid
Ibrahim, Ibrahim K.
Alfeel, Ayman H.
Alanazi, Abdullah M.
Alanazi, Abdulmajeed M.
Alruwaili, Abdulaziz M.
Alanazi, Muath H.
Alshaikh, Nahla A.
author_facet Abdalhabib, Ezeldine K.
Algarni, Abdulrahman
Saboor, Muhammad
Alanazi, Fehaid
Ibrahim, Ibrahim K.
Alfeel, Ayman H.
Alanazi, Abdullah M.
Alanazi, Abdulmajeed M.
Alruwaili, Abdulaziz M.
Alanazi, Muath H.
Alshaikh, Nahla A.
author_sort Abdalhabib, Ezeldine K.
collection PubMed
description TNF–α influences lymphomagenesis by upregulating proinflammatory and antiapoptotic pathways. In this study, we evaluated the frequency of TNF–α rs1800629 (–308 G>A) polymorphism in newly diagnosed adult patients with acute lymphoblastic leukemia (ALL) and its correlation with age at diagnosis, gender and subtype of ALL. In this case control study, a total of 330 individuals were recruited, including 165 newly diagnosed adult patients with ALL, from the Radiation and Isotope Center in Khartoum (RICK) and 165 healthy normal controls. TNF–α rs1800629 polymorphism was tested through allele-specific polymerase chain reaction (PCR) assay. The frequency of the rs1800629 GA genotype was high (70.9% vs. 60%, OR = 1.84) in the patient group as compared to healthy controls, whereas GG and AA genotypes did not exhibit any statistically significant difference between controls and patients. Based on subtype, GG and GA rs1800629 genotypes showed increased risk of B-ALL (OR 0.46 and 2.12, respectively), whereas rs1800629 GG, GA and AA genotypes did not show any disease association with T-ALL (p > 0.05). Age at diagnosis and gender did not exhibit any association of rs1800629 with ALL in the patient group. In conclusion, rs1800629 is associated with high risk of adult B-ALL, with an insignificant effect of age at diagnosis and gender.
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spelling pubmed-93207512022-07-27 Association of TNF–α rs1800629 with Adult Acute B-Cell Lymphoblastic Leukemia Abdalhabib, Ezeldine K. Algarni, Abdulrahman Saboor, Muhammad Alanazi, Fehaid Ibrahim, Ibrahim K. Alfeel, Ayman H. Alanazi, Abdullah M. Alanazi, Abdulmajeed M. Alruwaili, Abdulaziz M. Alanazi, Muath H. Alshaikh, Nahla A. Genes (Basel) Article TNF–α influences lymphomagenesis by upregulating proinflammatory and antiapoptotic pathways. In this study, we evaluated the frequency of TNF–α rs1800629 (–308 G>A) polymorphism in newly diagnosed adult patients with acute lymphoblastic leukemia (ALL) and its correlation with age at diagnosis, gender and subtype of ALL. In this case control study, a total of 330 individuals were recruited, including 165 newly diagnosed adult patients with ALL, from the Radiation and Isotope Center in Khartoum (RICK) and 165 healthy normal controls. TNF–α rs1800629 polymorphism was tested through allele-specific polymerase chain reaction (PCR) assay. The frequency of the rs1800629 GA genotype was high (70.9% vs. 60%, OR = 1.84) in the patient group as compared to healthy controls, whereas GG and AA genotypes did not exhibit any statistically significant difference between controls and patients. Based on subtype, GG and GA rs1800629 genotypes showed increased risk of B-ALL (OR 0.46 and 2.12, respectively), whereas rs1800629 GG, GA and AA genotypes did not show any disease association with T-ALL (p > 0.05). Age at diagnosis and gender did not exhibit any association of rs1800629 with ALL in the patient group. In conclusion, rs1800629 is associated with high risk of adult B-ALL, with an insignificant effect of age at diagnosis and gender. MDPI 2022-07-13 /pmc/articles/PMC9320751/ /pubmed/35886021 http://dx.doi.org/10.3390/genes13071237 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Abdalhabib, Ezeldine K.
Algarni, Abdulrahman
Saboor, Muhammad
Alanazi, Fehaid
Ibrahim, Ibrahim K.
Alfeel, Ayman H.
Alanazi, Abdullah M.
Alanazi, Abdulmajeed M.
Alruwaili, Abdulaziz M.
Alanazi, Muath H.
Alshaikh, Nahla A.
Association of TNF–α rs1800629 with Adult Acute B-Cell Lymphoblastic Leukemia
title Association of TNF–α rs1800629 with Adult Acute B-Cell Lymphoblastic Leukemia
title_full Association of TNF–α rs1800629 with Adult Acute B-Cell Lymphoblastic Leukemia
title_fullStr Association of TNF–α rs1800629 with Adult Acute B-Cell Lymphoblastic Leukemia
title_full_unstemmed Association of TNF–α rs1800629 with Adult Acute B-Cell Lymphoblastic Leukemia
title_short Association of TNF–α rs1800629 with Adult Acute B-Cell Lymphoblastic Leukemia
title_sort association of tnf–α rs1800629 with adult acute b-cell lymphoblastic leukemia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320751/
https://www.ncbi.nlm.nih.gov/pubmed/35886021
http://dx.doi.org/10.3390/genes13071237
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