Determining the International Spread of B.1.1.523 SARS-CoV-2 Lineage with a Set of Mutations Highly Associated with Reduced Immune Neutralization

Here, we report the emergence of the variant lineage B.1.1.523 that contains a set of mutations including 156_158del, E484K and S494P in the spike protein. E484K and S494P are known to significantly reduce SARS-CoV-2 neutralization by convalescent and vaccinated sera and are considered as mutations...

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Autores principales: Zemaitis, Lukas, Alzbutas, Gediminas, Gecys, Dovydas, Pautienius, Arnoldas, Ugenskiene, Rasa, Sukys, Marius, Lesauskaite, Vaiva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320768/
https://www.ncbi.nlm.nih.gov/pubmed/35889075
http://dx.doi.org/10.3390/microorganisms10071356
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author Zemaitis, Lukas
Alzbutas, Gediminas
Gecys, Dovydas
Pautienius, Arnoldas
Ugenskiene, Rasa
Sukys, Marius
Lesauskaite, Vaiva
author_facet Zemaitis, Lukas
Alzbutas, Gediminas
Gecys, Dovydas
Pautienius, Arnoldas
Ugenskiene, Rasa
Sukys, Marius
Lesauskaite, Vaiva
author_sort Zemaitis, Lukas
collection PubMed
description Here, we report the emergence of the variant lineage B.1.1.523 that contains a set of mutations including 156_158del, E484K and S494P in the spike protein. E484K and S494P are known to significantly reduce SARS-CoV-2 neutralization by convalescent and vaccinated sera and are considered as mutations of concern. Lineage B.1.1.523 presumably originated in the Russian Federation and spread across European countries with the peak of transmission in April–May 2021. The B.1.1.523 lineage has now been reported from 31 countries. In this article, we analyze the possible origin of this mutation subset and its immune response using in silico methods.
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spelling pubmed-93207682022-07-27 Determining the International Spread of B.1.1.523 SARS-CoV-2 Lineage with a Set of Mutations Highly Associated with Reduced Immune Neutralization Zemaitis, Lukas Alzbutas, Gediminas Gecys, Dovydas Pautienius, Arnoldas Ugenskiene, Rasa Sukys, Marius Lesauskaite, Vaiva Microorganisms Article Here, we report the emergence of the variant lineage B.1.1.523 that contains a set of mutations including 156_158del, E484K and S494P in the spike protein. E484K and S494P are known to significantly reduce SARS-CoV-2 neutralization by convalescent and vaccinated sera and are considered as mutations of concern. Lineage B.1.1.523 presumably originated in the Russian Federation and spread across European countries with the peak of transmission in April–May 2021. The B.1.1.523 lineage has now been reported from 31 countries. In this article, we analyze the possible origin of this mutation subset and its immune response using in silico methods. MDPI 2022-07-05 /pmc/articles/PMC9320768/ /pubmed/35889075 http://dx.doi.org/10.3390/microorganisms10071356 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zemaitis, Lukas
Alzbutas, Gediminas
Gecys, Dovydas
Pautienius, Arnoldas
Ugenskiene, Rasa
Sukys, Marius
Lesauskaite, Vaiva
Determining the International Spread of B.1.1.523 SARS-CoV-2 Lineage with a Set of Mutations Highly Associated with Reduced Immune Neutralization
title Determining the International Spread of B.1.1.523 SARS-CoV-2 Lineage with a Set of Mutations Highly Associated with Reduced Immune Neutralization
title_full Determining the International Spread of B.1.1.523 SARS-CoV-2 Lineage with a Set of Mutations Highly Associated with Reduced Immune Neutralization
title_fullStr Determining the International Spread of B.1.1.523 SARS-CoV-2 Lineage with a Set of Mutations Highly Associated with Reduced Immune Neutralization
title_full_unstemmed Determining the International Spread of B.1.1.523 SARS-CoV-2 Lineage with a Set of Mutations Highly Associated with Reduced Immune Neutralization
title_short Determining the International Spread of B.1.1.523 SARS-CoV-2 Lineage with a Set of Mutations Highly Associated with Reduced Immune Neutralization
title_sort determining the international spread of b.1.1.523 sars-cov-2 lineage with a set of mutations highly associated with reduced immune neutralization
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320768/
https://www.ncbi.nlm.nih.gov/pubmed/35889075
http://dx.doi.org/10.3390/microorganisms10071356
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