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Direct Affinity Purification of Long‐Acting PASylated Proteins with Therapeutic Potential Using L‐Prolinamide for Mild Elution

Both insufficient plasma half‐life (circulation for only few hours or less) and laborious downstream purification can be bottleneck for biological drug development. We report a novel strategy for the efficient and gentle affinity purification of pharmacologically relevant proteins modified by PASyla...

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Detalles Bibliográficos
Autores principales:	Schilz, Jonas, Clement, Charlotte, Greiner, Franziska, Skerra, Arne
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Communications
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320812/ https://www.ncbi.nlm.nih.gov/pubmed/35325504 http://dx.doi.org/10.1002/anie.202200079

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