Suppression of Sost/Sclerostin and Dickkopf‐1 Augment Intervertebral Disc Structure in Mice

Intervertebral disc (IVD) degeneration is a leading cause of low back pain, characterized by accelerated extracellular matrix breakdown and IVD height loss, but there is no approved pharmacological therapeutic. Deletion of Wnt ligand competitor Lrp5 induces IVD degeneration, suggesting that Wnt sign...

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Detalles Bibliográficos
Autores principales: Kroon, Tori, Bhadouria, Neharika, Niziolek, Paul, Edwards, Daniel, Choi, Roy, Clinkenbeard, Erica L, Robling, Alexander, Holguin, Nilsson
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320845/
https://www.ncbi.nlm.nih.gov/pubmed/35278242
http://dx.doi.org/10.1002/jbmr.4546

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9320845/
https://www.ncbi.nlm.nih.gov/pubmed/35278242
http://dx.doi.org/10.1002/jbmr.4546

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